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Wyświetlanie 1-15 z 19
Tytuł:
Trichinellosis in Byelorussia
Autorzy:
Skripova, L. V.
Kovchur, V. N.
Powiązania:
https://bibliotekanauki.pl/articles/2151504.pdf
Data publikacji:
1994
Wydawca:
Polskie Towarzystwo Parazytologiczne
Tematy:
house mice
pig
mouse
cat
infection
mice
Trichinella
trichinellosis
dog
animal disease
Belorussia
Źródło:
Wiadomości Parazytologiczne; 1994, 40, 4; 389-391
0043-5163
Pojawia się w:
Wiadomości Parazytologiczne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The phenomenon of apoptosis in the course of experimental trichinellosis in mice
ZJAWISKO APOPTOZY W PRZEBIEGU DOŚWIADCZALNEJ WŁOŚNICY U MYSZY
Autorzy:
Karmańska, K.
Houszka, M.
Piekarska, J.
Powiązania:
https://bibliotekanauki.pl/articles/2148536.pdf
Data publikacji:
2000
Wydawca:
Polskie Towarzystwo Parazytologiczne
Tematy:
mouse
mice
trichinellosis
larva
apoptosis
Trichinella spiralis
Opis:
Mice infected with 200 Trichinella spiralis larvae were killed at 3-69 days post infection (dpi) and the jejunum and masseter muscles were sectioned in a cryostat and examined in the Tuneli method with "In situ Cell Detected Kid POD" of Boehringer-Mannheim. Data concering the exact localization and dynamie of apoptic cells in both organs are presented. The authors conclude that apoptosis plays a important role in the pathogenesis of trichinellosis.
Źródło:
Wiadomości Parazytologiczne; 2000, 46, 1; 111-115
0043-5163
Pojawia się w:
Wiadomości Parazytologiczne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Effect of Ascaris trypsin inhibitor on fetal development of mice
Autorzy:
Błaszkowska, J.
Powiązania:
https://bibliotekanauki.pl/articles/2146383.pdf
Data publikacji:
2005
Wydawca:
Polskie Towarzystwo Parazytologiczne
Tematy:
mouse
mice
trypsin inhibitor
fetal development
Ascaris suum
Opis:
In this study, maternal toxicity and developmental effects of exposure to Ascaris trypsin inhibitor were evaluated in mice. Pregnant BALB/c females were injected intraperitoneally by Ascaris inhibitor /AIT/ at 200, 300, and 400 mg/kg body weight/day, on days 12 to 15 of gestation (stage of fetal development). At day 19 of pregnancy, uterine contents were inspected for implantation sites, early resorptions (moles), living fetuses and dead fetuses. The living fetuses were weighed and examined for external, internal and skeletal abnormalities. The results showed that AIT induced maternal toxicity, evidenced by maternal deaths, abortions, bleeding from uterus and reduced body weight gain as compared to control (p <0.01). There were no differences between the control group and the rest of all groups investigated for total implantation sites and early resorptions. Fetotoxicity was observed as shown by the decrease in the number of living fetuses and mean fetal weight, a high rate of intrauterine fetal deaths, delayed skeletal ossification, occurrence of pathological changes of fetal organs and tissues. Only one type of congenital malformations (hydronephrosis) was noted in fetuses after injection of higher doses of AIT.
Źródło:
Wiadomości Parazytologiczne; 2005, 51, 2; 133-138
0043-5163
Pojawia się w:
Wiadomości Parazytologiczne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Effect of Ascaris chymotripsin inhibitor on fetal development of mice
Autorzy:
Błaszkowska, J.
Powiązania:
https://bibliotekanauki.pl/articles/2147464.pdf
Data publikacji:
2004
Wydawca:
Polskie Towarzystwo Parazytologiczne
Tematy:
mouse
mice
fetal development
Ascaris suum
chymotrypsin inhibitor
Opis:
BALB/c mice were given daily doses of 40-80 mg of Ascaris chymotrypsin inhibitor /AChl/ per kg body weight from 12" until 15" day of gestation (stage of fetal development). It has been found that injection of AChI disturbed the course of pregnancy (bleeding from uterus, abortions, decreased body weight gain as compared to control /p < 0.05/). AChI exhibited embryotoxic effects (a high rate of intrauterine deaths, decreased number of living fetuses and mean fetal weight, delayed skeletal ossification, induced pathological changes of fetal organs and tissues). Congenital malformation (hydronephrosis) was noted in fetuses after injection of higher doses of the chymotrypsin inhibitor from Ascaris.
Źródło:
Wiadomości Parazytologiczne; 2004, 50, 3; 513-518
0043-5163
Pojawia się w:
Wiadomości Parazytologiczne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Preliminary evaluation of maternotoxic effect of Ascaris alpha-chymotrypsin inhibitor in mice
WSTĘPNA OCENA TOKSYCZNEGO DZIAŁANIA INHIBITORA о-СНУМОТВУРЗУМУ 7 ASCARIS NA ORGANIZM CIĘŻARNYCH MYSZY
Autorzy:
Blaszkowska, J.
Kadłubowski, R.
Powiązania:
https://bibliotekanauki.pl/articles/2148308.pdf
Data publikacji:
2001
Wydawca:
Polskie Towarzystwo Parazytologiczne
Tematy:
parasite
pregnancy
mouse
mice
Ascaris
host organism
toxic effect
alpha-chymotrypsin inhibitor
Opis:
Administration intraperitoneally of the Ascaris α-chymotrypsin inhibitor (40-300 mg/kg/day.) at a late stage of organogenesis (8-12 days of gestation) disturbed course of mouse pregnancy. The low doses of α-chymotrypsin inhibitor (40-80 mg/kg/day) significantly decreased the number of live fetuses per litter, increased the number of fetal resorptions. The symptoms of matemal toxicity that occurred after administration of the highest doses of the inhibitor (80-300 mg/kg/day) to pregnant mice included: decreased body weight gain as compared to control, vaginal hemorrhage, intrauterine resorption of litters, abortions, altered behaviour of animals immediately after injection and death. There is a linear interrelationship between the logarithm of the doses of the inhibitor and mortality of pregnant mice. The DL50 value of the inhibitor for female was 116 mg/kg /day (confidence interval: 95.5-140.0 mg/kg/day).
Źródło:
Wiadomości Parazytologiczne; 2001, 47, 4; 705-710
0043-5163
Pojawia się w:
Wiadomości Parazytologiczne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Glutathione-S-transferase activity in mouse muscle during experital trichinellosis
Autorzy:
Derda, M.
Wandurska-Nowak, E.
Boczoń, K.
Powiązania:
https://bibliotekanauki.pl/articles/2147897.pdf
Data publikacji:
2001
Wydawca:
Polskie Towarzystwo Parazytologiczne
Tematy:
parasite
glutathione s-transferase
infection
muscle
mouse
Trichinella
mice
trichinellosis
host
skeletal muscle
Opis:
The role of glutathione-S-transferase (GST, EC 2.5.1.18) in biochemical host defence in experimental trichinellosis was evaluated. The activity of GST in mouse skeletal muscles was measured during the muscular phase of trichinellosis, starting from the 3rd week post infection (w.p.i.) to the 11th w.p.i. Activity was determined spectrophotometrically by monitoring the formation of thioether (S-2,4-dinitrophenylglutathione) from the reduced form of glutathione and 1-chloro-2,4-dinitrobenzene used as a substrate and as an example of xenobiotics. The changes in the activity of GST were as follows: an increase in activity starts in the 4th w.p.i., peaks (up to 310% of the normal value) in the 6th w.p.i., decreases in the 8th week and a final, weak rise was observed in week 11. The statistically significant changes in GST activity in this phase of experimental trichinellosis suggest that this enzyme participates in the biochemical defence of the host against Trichinella infection.
Źródło:
Wiadomości Parazytologiczne; 2001, 47, 2; 227-232
0043-5163
Pojawia się w:
Wiadomości Parazytologiczne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Specific anti-Toxoplasma gondii antibodies produced in inbred mice differring in their natural resistance to toxoplasmosis
Autorzy:
Dytnerska, K.
Gatkowska, J.
Długońska, H.
Powiązania:
https://bibliotekanauki.pl/articles/2147473.pdf
Data publikacji:
2004
Wydawca:
Polskie Towarzystwo Parazytologiczne
Tematy:
specific antibody
toxoplasmosis
production
mouse
natural resistance
mice
Toxoplasma gondii
inbred strain
Opis:
The laboratory diagnostics of T. gondii infections both in humans and animals relies mainly upon detection of specific antibodies. We studied the influence of the host genetic factors on the level and repertoire of antibodies produced in Toxoplasma infection employing as an experimental model two inbred mouse strains with different innate susceptibility to toxoplasmosis. Using polyvalent antigen preparations in ELISA and microagglutination we found no differences in the antibody levels in both strains. By comparison of the antibody profiles in immunoblot we determined mouse strain-specific and common toxoplasmosis markers.
Źródło:
Wiadomości Parazytologiczne; 2004, 50, 3; 411-416
0043-5163
Pojawia się w:
Wiadomości Parazytologiczne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Disturbances of mouse pregnancy after injection of Ascaris homogenate during early organogenesis
ZABURZENIA PRZEBIEGU CIĄŻY U MYSZY PO INIEKCJI HOMOGENATU Z ASCARIS W CZASIE WCZESNEJ ORGANOGENEZY
Autorzy:
Blaszkowska, J.
Powiązania:
https://bibliotekanauki.pl/articles/2148586.pdf
Data publikacji:
2000
Wydawca:
Polskie Towarzystwo Parazytologiczne
Tematy:
tegumental homogenate
mouse
mice
Ascaris
Ascaris suum
organogenesis
homogenate
embryotoxicity
pregnancy
teratogenicity
Opis:
Administration of the Ascaris tegumental homogenate (0.6-1.2 g of Ascaris proteins/kg/day) at a early stage of organogenesis (5-9 days of pregnancy) had a harmful effect upon the developing mouse fetuses. It has been found that injection of the homogenate did not delay or prevent implantation, but causes a high rate of intrauterine deaths. The Ascaris homogenate significantly decreased the number of live fetuses per litter, increased the frequency of litter resorption, produced a delay in bone formation and induced pathological changes of fetal organs and tissues. The congenital malformations were noted in fetuses after injection of higher doses of Ascaris homogenate (exencephaly, craniomeningocele and intemal hydrocephalus). No malformations were noted in control groups and after injection of minimum dose of the homogenate. The symptoms that occurred after administration of the tegumental homogenate to pregnant mice included: decreased body weight gain (p<0.001) as compared to controls, vaginal hemorrhage, intrauterine resorption of litter and mortality. These signs suggest that the Ascaris homogenate causes matemal toxicity.
Źródło:
Wiadomości Parazytologiczne; 2000, 46, 3; 369-378
0043-5163
Pojawia się w:
Wiadomości Parazytologiczne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Attempts of modification of apoptosis in the course of experimental trichinellosis in mice
Autorzy:
Karmańska, K.
Piekarska, J.
Widyma, A.
Powiązania:
https://bibliotekanauki.pl/articles/2147890.pdf
Data publikacji:
2001
Wydawca:
Polskie Towarzystwo Parazytologiczne
Tematy:
inflammatory infiltration
parasite
mouse
mice
trichinellosis
jejunum mucosa
experimental trichinellosis
apoptosis
modification
Opis:
The influence of the some immunomodulators (PHA-P, TFX and dexamethasone) on the process of apoptosis, occurring in the course of trichinellosis in mice, has been studied. It has been found that PHA-P activates this process in the jejunum mucosa and prolongs it in the muscular inflammatory infiltration, whereas TFX has no influence and dexamethasone distinctly decreases the level of the apoptotic cells. The number of the intestinal trichinae on the successive days of infection was similar in all groups of animals, however, the number of the muscular larvae in the groups receiving immunostimulators was much lower and in the group treated with dexamethasone - a little higher than that in control. As in mice receiving PHA-P and TFX, the cellular inflammatory infiltration in the muscles was larger than that in control, and in the group to which dexamethasone was administrated - smaller, the authors think that it was extensiveness of the infiltration and not the level of the apoptotic cells that influenced the number of the outliving larvae.
Źródło:
Wiadomości Parazytologiczne; 2001, 47, 2; 211-216
0043-5163
Pojawia się w:
Wiadomości Parazytologiczne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The mucosal mast cell and IgA plasma cell responses to primary Trichinella spiralis infection in BALB-c mice treated with ketotifen
WPŁYW KETOTIFENU NA ODPOWIEDŹ KOMÓREK TUCZNYCH I PLAZMOCYTÓW IgA W PIERWOTNEJ INWAZJI TRICHINELLA SPIRALIS U MYSZY BALB/c
Autorzy:
Doligalska, M.
Laskowska, M.
Powiązania:
https://bibliotekanauki.pl/articles/2148474.pdf
Data publikacji:
2001
Wydawca:
Polskie Towarzystwo Parazytologiczne
Tematy:
ketotifen
plasma cell
mucosal mast cell
mouse
infection
mice
mast cell
inflammation
Trichinella spiralis
Opis:
The effect of ketotifen on inflammation in the intestine during T. spiralis infection in BALB/c mice was examined. The lack of enteropathy in treated mice was accompanied to affected the size of worms and the number of worms, but did not prevent the retardation of nematodes in the intestine. Fecundity of females in vitro and the number of muscle larvae were not statistically changed after treatment. Ketotifen reduced the number of mast cells and IgA plasma cells in the intestine. As inflammatory influx, epithelial damage and IgA response are related to the action of T cells, ketotifen affected T dependent reactions in the gut of T. spiralis infected mice.
Źródło:
Wiadomości Parazytologiczne; 2001, 47, 4; 597-601
0043-5163
Pojawia się w:
Wiadomości Parazytologiczne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The cells observed inside capsules of larvae in the course of experimental trichinellosis in mice
Autorzy:
Karmańska, K.
Houszka, M.
Widyma, A.
Stefaniak, E.
Powiązania:
https://bibliotekanauki.pl/articles/2148907.pdf
Data publikacji:
1997
Wydawca:
Polskie Towarzystwo Parazytologiczne
Tematy:
immunoenzymatic method
larva capsule
infection
muscle
mouse
mice
cell
macrophage
trichinellosis
monoclonal antibody
Opis:
In the course of trichinellosis in mice the numerous cells inside larval capsules were observed. Beginning on 14 day post infection (dpi) they were seen in about 7% of infected muscles fibers but at 21 dpi the percentage of capsules with the cells amounted to 77. In the next stage of infection the number of capsules containing cells continued to increase and reach almost 100% at 60 dpi. The identification of the cells was carried out by the indirect immunoenzymatic method using anti-CD4⁺, anti-CD8⁺ and anti-macrophage (Mac-1 antigen) monoclonal antibodies. In course of observation the level of CD4⁺ cells decreased from 11.3 to 0.7, of CD8⁺ from 17.7 to 3.0 and of macrophages from 71.0 to 23.1 %. The most numerous CD4⁺ cells were seen at 14 dpi while the CD8⁺ and macrophages at 21 dpi. Beginning on 28 dpi negatively reacting cells inside larval capsules were also observed. The number of these cells increased from 23.8 to 73.2% at 60 dpi and their identification requires further investigations. The role and the function of all these cells are discussed.
Źródło:
Wiadomości Parazytologiczne; 1997, 43, 3; 251-256
0043-5163
Pojawia się w:
Wiadomości Parazytologiczne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Parasitological appraisal of TFX-Thymomodulin effect on the course of intestinal and muscular invasion in mice infected with Trichinella spiralis
Autorzy:
Iwanow, M.
Powiązania:
https://bibliotekanauki.pl/articles/2151499.pdf
Data publikacji:
1994
Wydawca:
Polskie Towarzystwo Parazytologiczne
Tematy:
parasite
muscular invasion
intestinal invasion
mouse
muscle
infection
mice
TFX-Thymomodulin
Trichinella spiralis
Opis:
Studies were undertaken to evaluate by parasitological techniques the course of intestinal and muscular invasions in mice infected with Trichinella spiralis and treated with TFX-Thymomodulin (TFX-Th). Studies were conducted on 120 mice of BALB/c and SWISS strains, infected each with a mean invasive dose of 300 T. spiralis larvae. TFX-Th (Thymoorgan GmbH Pharmazie Co. KG, Vienenburg, Germany) was administered subcutaneously at 30 mg/kg body weight. Depending upon duration of TFX-Th administration and stages of intestinal and muscular invasions, three experiments were distinguished in the study. The results indicated that TFX-Th promoted eradication of larvae from muscles, whether administered at the early of the late stage of T. spiralis invasion.
Źródło:
Wiadomości Parazytologiczne; 1994, 40, 4; 337-356
0043-5163
Pojawia się w:
Wiadomości Parazytologiczne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Macrophages during infection with Trichinella spiralis in mice
Autorzy:
Karmańska, K.
Houszka, M.
Widyma, A.
Stefaniak, E.
Powiązania:
https://bibliotekanauki.pl/articles/2148900.pdf
Data publikacji:
1997
Wydawca:
Polskie Towarzystwo Parazytologiczne
Tematy:
larva capsule
immunoenzymatic technique
mouse
infection
mice
trichinellosis
macrophage
monoclonal antibody
Trichinella spiralis
muscle tissue
Opis:
Behaviour of macrophages in experimental mice trichinellosis, was investigated using the immunoenzymatic technique with monooclonal antibodies CD11b/CD18 within the framework of avidin-biotin-DAB. The maximum and earliest mobilization of macrophages 7 day post infection (dpi) was observed in the lamina propria of the intestinal mucosa. The highest level of macrophages in the muscles tissue was noted on day 21 of infection, however as early as in 28 dpi, their maximum level was observed inside the larval capsules. They line, especially between 35-42 dpi internal capsule surphace.
Źródło:
Wiadomości Parazytologiczne; 1997, 43, 3; 245-249
0043-5163
Pojawia się w:
Wiadomości Parazytologiczne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Preliminary evaluation of maternotoxic effect of Ascaris extract in mice
Autorzy:
Błaszkowska, J.
Powiązania:
https://bibliotekanauki.pl/articles/2147625.pdf
Data publikacji:
2003
Wydawca:
Polskie Towarzystwo Parazytologiczne
Tematy:
pregnancy
disturbance
mouse
mice
mortality
extract
Ascaris suum
maternal effect
toxic effect
embryotoxicity
evaluation
Opis:
Administration intraperitoneally of the Ascaris suum extract - ASE-(0.6-1.4 g of Ascaris proteins/kg/day) at a late stage of organogenesis (8-12 days of gestation) disturbed course of mouse pregnancy. lt has been found that injections of higher doses of ASE to pregnant mice caused the symptoms manifesting maternal toxicity (decreased body weight gain /p < 0.001/ as compared to control, intrauterine resorption of litter, vaginal hemorrhages, female mortality and altered behaviour). There is a linear interrelationship between the logarithm of the dose of ASE and mortality of pregnant mice. The DL₅₀ value of Ascaris proteins for pregnant mice was 1.02 g/kg/day (confidence interval 0.97-1.07 g/kg/day). ASE exerted embryotoxic effects: significantly decreased the number of surviving fetuses per litter and the mean body weight of fetuses, increased the number of fetal resorptions.
Źródło:
Wiadomości Parazytologiczne; 2003, 49, 2; 187-194
0043-5163
Pojawia się w:
Wiadomości Parazytologiczne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
CD4+ and CD8+ cells in mice infected with Trichinella spiralis and treated with cyclosporine A
Autorzy:
Karmańska, K.
Houszka, M.
Miśta, D.
Stefaniak, E.
Powiązania:
https://bibliotekanauki.pl/articles/2151487.pdf
Data publikacji:
1994
Wydawca:
Polskie Towarzystwo Parazytologiczne
Tematy:
immunoenzymatic method
mouse
infection
mice
cell
T lymphocyte
immunofluorescent method
cyclosporin A
larva
Trichinella spiralis
Opis:
Studies were undertaken to evaluate by parasitological techniques the course of intestinal and muscular invasions in mice infected with Trichinella spiralis and treated with TFX-Thymomodulin (TFX-Th). Studies were conducted on 120 mice of BALB/c and SWISS strains, infected each with a mean invasive dose of 300 T. spiralis larvae. TFX-Th (Thymoorgan GmbH Pharmazie Co. KG, Vienenburg, Germany) was administered subcutaneously at 30 mg/kg body weight. Depending upon duration of TFX-Th administration and stages of intestinal and muscular invasions, three experiments were distinguished in the study. The results indicated that TFX-Th promoted eradication of larvae from muscles, whether administered at the early of the late stage of T. spiralis invasion.
Źródło:
Wiadomości Parazytologiczne; 1994, 40, 4; 357-362
0043-5163
Pojawia się w:
Wiadomości Parazytologiczne
Dostawca treści:
Biblioteka Nauki
Artykuł
Wyświetlanie 1-15 z 19

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