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    Wyświetlanie 1-8 z 8
    Tytuł:
    Różnorodne aspekty aktywności biologicznej IL-1. 1. Rola IL-1 w inwazjach pasożytniczych
    Various aspects of IL-1 biological activity. 1. The role of IL-1 in parasitic infections
    Autorzy:
    Gatkowska, J.
    Powiązania:
    https://bibliotekanauki.pl/articles/2143526.pdf
    Data publikacji:
    2009
    Wydawca:
    Polskie Towarzystwo Parazytologiczne
    Tematy:
    inwazja pasozytnicza
    interleukina 1
    aktywnosc biologiczna
    cytokiny
    Opis:
    Interleukin–1 is one of the most potent proinflammatory cytokines involved in many physiologically important processes both beneficial and pathological. It appears in two different forms: IL-1 and IL-1b synthesized mainly by macrophages and monocytes. IL-1 remains inside the cells and is released during acute inflammatory diseases accompanied by cell lysis. IL-1b becomes biologically active after specific cleavage and is secreted to fulfill its multitude functions. This cytokine is involved in multiple gene up-regulation, higher expression of many cytokine receptors or induction of nitric oxide synthesis. Interleukin-1 is responsible for symptoms like fever or appetite loss during inflammatory diseases. It is capable of lymphocytes, macrophages or NK cells activation. This cytokine has a chemoattractant activity toward neutrophiles and monocytes and takes part in Th2 response development. Apart from other functions and activities, IL-1 is associated with many invasive illnesses such as parasitic infections. This cytokine influences the outcome of numerous parasitoses since it can limit parasite spread and survival within infected host by cooperation with other components of the immunological system and by the induction of anti-parasitic compounds. However, the proinflammatory activity of IL-1 may prove harmful in certain cases and may be responsible for parasite infection development.
    Źródło:
    Wiadomości Parazytologiczne; 2009, 55, 2; 109-114
    0043-5163
    Pojawia się w:
    Wiadomości Parazytologiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Różnorodne aspekty aktywności biologicznej IL-1. 2. IL-1beta w stanach chorobowych a OUN
    Various aspects of IL-1 biological activity. 2. IL-1beta in diseases and the Central Nervous System
    Autorzy:
    Wieczorek, M.
    Powiązania:
    https://bibliotekanauki.pl/articles/2143527.pdf
    Data publikacji:
    2009
    Wydawca:
    Polskie Towarzystwo Parazytologiczne
    Tematy:
    uklad nerwowy osrodkowy
    uklad odpornosciowy
    uklad hormonalny
    osrodkowy uklad nerwowy zob.uklad nerwowy osrodkowy
    zachowania chorobowe
    przekazywanie sygnalow
    choroby zakazne
    czasteczki sygnalowe
    aktywnosc biologiczna
    interleukina 1beta
    zmiany fizjologiczne
    cytokiny
    Opis:
    Precise understanding of the mechanisms of reciprocal relations between the nervous and the immune systems, has been the subject of numerous studies for the recent two decades. These mechanisms are significant, particularly at the stage of early response to bacterial, parasite, or viral infections. They are also essential from the medical point of view, as they may help in the development of the new methods of treatment of infectious diseases, and also may provide better methods to neutralize possible side effects of the therapy. As it is commonly understood, both forms of IL-1 ( and b), play an important role as a signaling molecules in these mechanisms. Regardless of the route of administration, they cause to the activation of the brain neurotransmitters, and the hypothalamo-pituitary-adrenal-axis (HPA). The HPA response induced by activity of the immune system is a normal, physiological phenomenon with essential meaning. It gives the negative feedback where glucocorticoids, released from the adrenal cortex, inhibit activity of the immune system, and by this reduce the probability of the over-stimulation of this system and its selfaggression. Therefore, precise recognition of the mechanism which is the indicator of influence of cytokines on the brain and also leads to initiate that response has a significant scientific and practical meaning. Also, the two mechanisms are probably the most important, and under appropriate conditions could complement each other. These are enzymatic and neural ways by which immune system influences the brain. The former predicts, that Il-1 influences the tissue, stimulating them to the synthesis, via the cyclooxygenases (COX) activation, and release molecules such as prostaglandines (especially PGE2), which have the ability to penetrate the brain barrier. The latter assumes that IL-1, directly or indirectly, can influence the peripheral nerves (the most important is probably the vagus nerve), which afferent sensory endings subsequently send signals to the brain. The results of many experiments (including the authors’ own) indicate that both mentioned above ways take part in the mechanism of the communication between the immune and the nervous systems. These point out that signaling via the vagus nerve and via COX may contribute to the effects of IL-1 administration on animals behavior, and the activation of HPA axis and brain neurochemistry. However, the vagal pathway and the COX-system appear to substitute each other during infections or pathogens invasion. The experimantal data also suggest that these two mechanisms by which IL-1 can affect the brain are probably the most important ones, by which the immune system influences the nervous system.
    Źródło:
    Wiadomości Parazytologiczne; 2009, 55, 2; 115-124
    0043-5163
    Pojawia się w:
    Wiadomości Parazytologiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Struktura infrapopulacji małoliczebnych i zagęszczonych tasiemca Hymenolepis diminuta linii wsobnej - WMS IL1
    Autorzy:
    Stradowski, M.
    Powiązania:
    https://bibliotekanauki.pl/articles/2147848.pdf
    Data publikacji:
    2001
    Wydawca:
    Polskie Towarzystwo Parazytologiczne
    Tematy:
    szczury
    linie wsobne
    struktura populacji
    zwierzeta doswiadczalne
    parazytologia
    pasozyty
    Hymenolepis diminuta
    tasiemce
    Opis:
    An average of 4.9 tapeworms were discovered on day 7 of a low-abundance H. diminuta infection of rats of race WAG alb. After 11 months, the mean was only relatively slightly tower at 3.6. These means represent 97.1 and 71.4% of the 5 cysticercoids supplied. In turn, 7 days and 11 months after rats were supplied with 110 cysticercoids, the respective percentages were 85.1 and 56.0. All 7- and 12-day tapeworms from the low-abundance and crowded infrapopulations were characterized by the presence of a terminal proglottid of lingulate shape, in which the excretory canals joined. In contrast, older (48-day and 11-month-old) worms showed typical apolysis of gravid proglottids. There were no reports of the destrobilation of tapeworms, and the relatively large number of tapeworms persisting 11 months into the infection is particularly noteworthy. The results point to the lack of any rapid rejection of tapeworms of the kind characterized in many other studies on H. diminuta.
    Źródło:
    Wiadomości Parazytologiczne; 2001, 47, 1; 127-135
    0043-5163
    Pojawia się w:
    Wiadomości Parazytologiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Intensified morphological variability during patency in Hymenolepis diminuta originating from inbred tapeworm - WMS IL1
    Nasilona zmienność morfologiczna w okresie patentnym u Hymenolepis diminuta pochodzących z hodowli wsobnej tasiemca - WMS IL1
    Autorzy:
    Stradowski, M.
    Powiązania:
    https://bibliotekanauki.pl/articles/2151384.pdf
    Data publikacji:
    1995
    Wydawca:
    Polskie Towarzystwo Parazytologiczne
    Tematy:
    zmiennosc morfologiczna
    inbred
    hodowla zwierzat
    parazytologia
    Hymenolepis diminuta
    tasiemce
    Opis:
    Variable position of genital ducts and pores (PGP) was found in 23.3% of five months old tapeworms obtained as a result of administering to rats a dose of 6 cysticercoids proceeding from the third generation of inbred Hymenolepis diminuta - WMS il1. In tapeworms coming from generations no 18 and 32 PGP changes were reported only in 7.5 month, with only 5.9% of strobilas in the 32 generation group being characterized by this feature. These results indicate a time shift with respect to the appearance of PGP changes in tapeworms proceeding from latter inbred generations to a further period of tapeworm invasion in rats. The number of PGP changes is positively correlated with the number of type 2p1a proglottids (two testes on the poral and one on the aporal side). The average number of type Op3a proglottids increases with the number of generations. In 5-month old tapeworms of unilateral PGP coming from generation no 3, 18 and 32 it amounts to 5.9%, 6.6% and 8.1 %, respectively.
    Źródło:
    Wiadomości Parazytologiczne; 1995, 41, 1; 33-41
    0043-5163
    Pojawia się w:
    Wiadomości Parazytologiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Wpływ doboru tasiemców macierzystych linii wsobnej Hymenolepis diminuta WMS IL1 na zmienność cech u tasiemców potomnych
    Autorzy:
    Stradowski, M.
    Powiązania:
    https://bibliotekanauki.pl/articles/2147675.pdf
    Data publikacji:
    2002
    Wydawca:
    Polskie Towarzystwo Parazytologiczne
    Tematy:
    proglotydy
    dobor zwierzat
    potomstwo
    linie wsobne
    zmiennosc cech
    parazytologia
    hodowla wsobna
    osobniki macierzyste
    Hymenolepis diminuta
    tasiemce
    Opis:
    A continuation of a single-individual culture of Hymenolepis diminuta WMS ill from generations 37 to 66 revealed a very high infective ability of cysticercoids which is reflected in the percentage of tapeworms detected in relation to the number of cysticercoids given to rats (94.4%). The tapeworms investigated revealed a significant increase in the abundance of type 0p3a proglottids (those wilh no testes on the poral side and 3 on the aporal) in tapeworms of successive generation groups. Each group of tapeworms analysed statistically belonged to three successive generations and numbered 31-34 individuals. The mean abundances of 0p3a type proglottids in tapeworms of the first groups studied in experiment, including generations 37-39 and 40-42 were 9.2% and 9.5%, respectively. The last studied groups, including generations 61-63 and 64-66 had higher mean numbers of type 0p3a proglottids, at 11.1 % and 11.5%, respectively. The quantitative figures of 1p3a type proglottids amounted to 1.6% and 1.3% in first generation groups and in the last two groups 0.8% and 1.0%, respectively. The probable cause of this significant (P < 0.01) relative increase in the numbers of 0p3a type proglottids and decrease (P < 0.01) in the numbers of 1p3a type proglottids was the deliberate selection of maternal tapeworms characterized by numbers of 0p3a type proglottids greater and 1p3a type proglottids smaller than the a verage for their generation.
    Źródło:
    Wiadomości Parazytologiczne; 2002, 48, 1; 79-85
    0043-5163
    Pojawia się w:
    Wiadomości Parazytologiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Stymulacja zmian morfologicznych u tasiemców pochodzących z odległych od wyjściowego pokoleń hodowli wsobnej Hymenolepis diminuta - WMS IL1
    Autorzy:
    Stradowski, M.
    Powiązania:
    https://bibliotekanauki.pl/articles/2149101.pdf
    Data publikacji:
    1995
    Wydawca:
    Polskie Towarzystwo Parazytologiczne
    Tematy:
    zmiany morfologiczne
    parazytologia
    hodowla wsobna
    stymulacja
    Hymenolepis diminuta
    tasiemce
    Opis:
    The investigations focused on tapeworms obtained as a result of the administration to individual rats a dose of 6 cysticercoids coming from the 39th and 40th generation of one-specimen inbred Hymenolepis diminuta - WMS il1. In 7.5-month old tapeworms the position of genital pores (PGP) was exclusively right-hand side with the genital ducts typical of this feature. Type 0p3a proglottids were the most common deviation from the typical number and topography of testes - 1p2a (one testis between the ovary and the genital pore marking the poral side and two testes on the aporal side) - in such tapeworms. Their mean incidence amounted to 8.9%, exceeding by at least 2.9% the mean quantitative value of this feature in tapeworms proceeding from non-inbred H. diminuta „strains" which have been subjected to similar studies. 19.5-month old tapeworms, exactly a year older than the previous ones, all had variable PGP. The number of PGP changes was here correlated positively with the number of type 2p1a proglottids and negatively with the number of type 1p2a and 0p3a proglottids.
    Źródło:
    Wiadomości Parazytologiczne; 1995, 41, 4; 399-404
    0043-5163
    Pojawia się w:
    Wiadomości Parazytologiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Biologiczne i anatomo-morfologiczne właściwości tasiemców Hymenolepis diminuta wms il1 i wms "strain"
    THE BIOLOGICAL AND ANATOMICAL-MORPHOLOGICAL PROPERTIES OF HYMENOLEPIS DIMINUTA TAPEWORMS OF WMS ILI AND THE WMS "STRAIN"
    Autorzy:
    Stradowski, M.
    Grytner-Zięcina, B.
    Rebandel, H.
    Powiązania:
    https://bibliotekanauki.pl/articles/2147924.pdf
    Data publikacji:
    2001
    Wydawca:
    Polskie Towarzystwo Parazytologiczne
    Tematy:
    wlasciwosci biologiczne
    wlasciwosci morfologiczne
    parazytologia
    wlasciwosci anatomiczne
    Hymenolepis diminuta
    tasiemce
    Opis:
    Crowded infrapopulations of H. diminuta obtained from the WMS i11 inbred line resembled those of the potentially non-inbred WMS strain in not showing either the abrupt reductions in the numbers of worms or the destrobilation described by other autors. Denser populations of both types of tapeworm have a greather abundance of 4 - testis proglottids of the lp3a type (having 1 testis on the poral side and three on the aporal), and fewer of type 0p3a. Changes in the positioning of genital ducts and pores show a marked positive correlation with the abundance of type 2pla proglottids. Strobilae of H. diminuta WMS i11 contain a relatively greather number of type 0p3a proglottids and fewer of type 1p3a, than those of the WMS „strain"; something which is probably linked with the respective selection of the maternal Tapeworms.
    Źródło:
    Wiadomości Parazytologiczne; 2001, 47, 3; 279-283
    0043-5163
    Pojawia się w:
    Wiadomości Parazytologiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Comparison of Hymenolepis diminuta WMS strain and WMS inbred line [IL1] at a time of intensified morphological variability of tapeworms
    PORÓWNANIE HYMENOLEPIS DIMINUTA „RASY” WMS Z LINIĄ WSOBNĄ 1 (LI) W OKRESIE NASILONEJ ZMIENNOŚCI MORFOLOGICZNEJ TASIEMCÓW
    Autorzy:
    Stradowski, M.
    Powiązania:
    https://bibliotekanauki.pl/articles/2148888.pdf
    Data publikacji:
    1998
    Wydawca:
    Polskie Towarzystwo Parazytologiczne
    Tematy:
    Hymenolepis diminuta
    strain
    morphological variability
    inbred line
    comparison
    tapeworm
    Opis:
    9-months tapeworms obtained from 3- 6-specimen populations of the 42nd generation of Hymenolepis diminuta WMS „strain" were compared with tapeworms obtained from quantitatively similar populations deriving from one-specimen infections of H. diminuta WMS il1. In both groups of tapeworms the majority of strobilas had unilateral position of genital pares (PGP), while the remaining ones were characterized by variable PGP. The latter appeared in 41.4% of H. diminuta WMS „strain" tapeworms and in only 24.6% of tapeworms coming from H. diminuta WMS il1. In tapeworms with unilateral as well as with variable PGP deriving from H. diminuta WMS il1, the average number of type 0p3a proglottids (all three testes on the aporal side) was significantly higher than in H. diminuta WMS „strain". It results most probably from suitable selection of mother specimens for successive generations of H. diminuta WMS il1. In both compared groups the growth of the number of PGP changes was correlated positively with the number of type 2p1a proglottids and negatively with the numer of type 1p2a and 0p3a proglottids.
    Źródło:
    Wiadomości Parazytologiczne; 1998, 44, 4; 681-691
    0043-5163
    Pojawia się w:
    Wiadomości Parazytologiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-8 z 8

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