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    Wyświetlanie 1-3 z 3
    Tytuł:
    Witaminy z grupy B : opis właściwości fizykochemicznych oraz bioaktywności z wykorzystaniem przykładowych narzędzi cheminformatycznych
    B vitamins : description of physicochemical properties and bioactivity by exemplary cheminformatics tools
    Autorzy:
    Banach, Sylwia
    Jezierska, Aneta
    Powiązania:
    https://bibliotekanauki.pl/articles/27310030.pdf
    Data publikacji:
    2023
    Wydawca:
    Polskie Towarzystwo Chemiczne
    Tematy:
    witaminy B
    cheminformatyka
    chemia medyczna
    projektowanie leków
    molinspiration
    bioaktywność
    B vitamins
    cheminformatics
    medicinal chemistry
    drug design
    bioactivity
    Opis:
    This paper presents a literature review of the biochemistry of vitamins B and the results of in silico physicochemical properties and bioactivity studies. The description was performed by cheminformatics tools closely related to the field of Medicinal Chemistry. It allows us to predict a great number of properties e.g. logP, TPSA, molecular volume or bioactivity associated with the chosen proteins (like kinases, proteases etc.). These investigations were carried out with the use of cheminformatics web tool Molinspiration. Its great advantages are mainly its wide availability, ease of application and quick analysis of small compounds. Thanks to the comparison with literature data of well–known B vitamins, it is possible to confirm that current cheminformatic web tools provide high reliability of the results and can support Drug Design methods.
    Źródło:
    Wiadomości Chemiczne; 2023, 77, 9-10; 873--896
    0043-5104
    2300-0295
    Pojawia się w:
    Wiadomości Chemiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Witamina C w medycynie i kosmetologii
    Vitamin C in medicine and cosmetology
    Autorzy:
    Musiał, Claudia
    Sawczuk, Wojciech
    Gawdzik, Barbara
    Kuban-Jankowska, Alicja
    Przychodzeń, Paulina
    Górska-Ponikowska, Magdalena
    Powiązania:
    https://bibliotekanauki.pl/articles/172737.pdf
    Data publikacji:
    2019
    Wydawca:
    Polskie Towarzystwo Chemiczne
    Tematy:
    kwas askorbinowy
    antyoksydant
    farmakoprewencja nowotworu
    wolne rodniki
    pochodne witaminy C
    ascorbic acid
    antioxidant
    cancer pharmacoprevention
    free radicals
    vitamin C derivatives
    Opis:
    Ascorbic acid is one of the strongest antioxidants. It has a protective function against oxidative stress intracellularly. It fights free radicals and eliminates the effects of ultraviolet radiation. The human body is unable to synthesize vitamin C itself. Vitamin C meets supports the mechanism of removing toxins from the human body and has anticancer activity. Over the years, many studies have been carried out to confirm the beneficial effect of preventive and supportive action of cytostatics in the treatment of cancer. Clinical studies described in the study indicate that vitamin C used in combination with a cytostatic drug - gemcystabine, shows no side effects. Vitamin C applied topically on the skin shows a number of positive effects. Studies have shown that vitamin C accumulates in the deeper layers of the skin for about three days. Ascorbic acid has a protective effect against harmful ultraviolet radiation. Manufacturers of cosmetics often add ascorbic acid to cosmetics with sunscreens. In addition, vitamin C acts depigmenting. In order to increase the brightening effect, vitamin C is often combined with glycolic acid or retinol. Ascorbic acid is also used in anti-aging preparations due to the high ability of collagen synthesis in the skin. In topical preparations, ascorbic acid has hydrophilic properties - it is soluble in water and insoluble in fats. Hydrophilic ascorbic acid in synergy with lipophilic tocopherol reduces cell apoptosis and thymine dimer formation. Its stability improves the presence of stabilizing antioxidants, such as vitamin E and ferulic acid. For the preparation to retain its properties, it should be protected from light and oxygen. The development of biotechnology allows the closure of a micronised vitamin C in nanosomes and liposomes, which increases the ability to penetrate deep into the skin. A number of vitamin C derivatives such as ascorbyl tetrapalmitate and ascorbyl phosphate magnesium help achieve the desired results in topical application.
    Źródło:
    Wiadomości Chemiczne; 2019, 73, 9-10; 503-522
    0043-5104
    2300-0295
    Pojawia się w:
    Wiadomości Chemiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Droga pod słońce. Wczesna historia witaminy D
    The route against the sun. Early history of vitamin D
    Autorzy:
    Wicha, J.
    Powiązania:
    https://bibliotekanauki.pl/articles/172567.pdf
    Data publikacji:
    2012
    Wydawca:
    Polskie Towarzystwo Chemiczne
    Tematy:
    witamina D
    biosynteza i żywienie
    sterole
    badanie struktury
    światło ultrafioletowe
    dieta przeciwkrzywicza
    historia witaminy D
    vitamin D
    biosynthesis
    nutrition
    sterols
    structural investigations
    ultraviolet light
    antirachitic diet
    Opis:
    Two natural products are called „vitamin D”: (1) vitamin D3 which is biosynthesized in humans and animals and (2) vitamin D2 which is generated in photochemical rearrangement of a sterol of fungy – ergosterol (Fig. 1 and 2). The vitamins D are further metabolized (Scheme 1) first into 25-hydroxy- and then into 1.,25-dihydroxy derivatives in various tissues. The compounds control the calcium transport and act as a cell growth regulator important for tumor prevention. The early history of vitamin D stems from outburst of rickets at the beginning of the industrialization era. Rickets was a child bond disease that often led to a permanent disability. A comprehensive description of the rickets was presented by D. Whistler ( 1619–1684) and then F. Glisson (1597–1677) and coauthors. Jędrzej Śniadecki ( 1768–1838) was the first who associated the rickets with the sunlight. In his book “On the Physical Education of Children” Śniadecki stated that exposition of a child’s body to a direct action of sunlight is the most efficient method for the prevention and the cure of rickets (Illustrations 1 and 2). T. A. Palm in 1890 observed that the rickets is rare in countries where sunshine is abundant and prevalent whenever there is a little of sunlight. The first experimental evidence on the sunlight effects in rickets were presented by J. R aczyński in 1912 who postulated that the sunlight affects metabolic processes in blood related to calcium transport (Illustration 3 and 4). E. Mellanby showed (1919) that the disease is connected to the lack of certain dietary factors and he recommended the use of cod liver – oil. K. Huldschinsky experimentally proved that UV irradiation cures the rickets. The Mellanby’s and Huldschinsky’s observations were confirmed by clinical studies in 1922. E.V. McCollum has developed efficient methods for “biological analysis” of food and named anti-rachitic factor as vitamin D.H. Steenbock and A.F. Hess in 1924 found independently that various food products gain anti-rachitic properties after being irradiated with a UV lamp. A.F. Hees and A. Windaus showed that irradiation of ergosterol affords a product with high anti-rachitic activity. In 1919 the first structure for cholesterol has been proposed by A. Windaus (Scheme 2, Fig. 3) and then with contribution of H. Wieland it was modified to the “Wieland-Windaus” structure (1928, Nobel Price lectures, Fig. 4). O. Diels’ investigation on dehydratation of cholesterol (Fig. 5) and J.D. Bernal’s crystallographic measurements of ergosterol challenged the Wieland-Windaus structure. Finally, the correct structure for cholic acid and sterols was deduced by O. Rosenheim and H. King (Fig. 6). In 1932 crystalline vitamin D2 was prepared in the Windaus laboratory (Scheme 3). In 1935 vitamin D3 was isolated from a fish-oil and the same compound was synthesized from cholesterol (Illustration 5). The structure of vitamin D2 was elucidated by Windaus in 1935 (Illustration 6) and confirmed by X-ray studies in 1948. Scientific contributions of Adolf Windaus are associated with his highest ethical standards and non-conformist political position in the national-socialist age.
    Źródło:
    Wiadomości Chemiczne; 2012, 66, 7-8; 671-696
    0043-5104
    2300-0295
    Pojawia się w:
    Wiadomości Chemiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-3 z 3

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