- Tytuł:
-
Enzymatyczne reakcje rozszczepienia wiązania C–C : zastosowanie w syntezie związków zapachowych, farmaceutyków oraz w bioremediacji
Enzymatic reactions of the C–C bond cleavage : applications in synthesis of aroma compounds, pharmaceuticals and in bioremediation - Autorzy:
-
Panek, A.
Milecka-Tronina, N.
Świzdor, A. - Powiązania:
- https://bibliotekanauki.pl/articles/172055.pdf
- Data publikacji:
- 2015
- Wydawca:
- Polskie Towarzystwo Chemiczne
- Tematy:
-
β-oksydacja
wanilina
γ-dekalakton
metyloketony
leki steroidowe
bioremediacja
β-oxidation
vanillin
γ-decalactone
methyl ketones
steroid drugs
bioremediation - Opis:
- The microorganisms are able to utilize natural and synthetic compounds of broad structural diversity as a source of carbon and energy, converting these substrates into low molecular weight products (mainly H2O, CO2 and NH3). The main role in this metabolism is played by the enzymes that catalyze reactions of the C–C bond cleavage. Such reactions are the key step of the primary metabolism of fatty acids in eukaryotic cells by the β-oxidation. The enzymatic systems associated with the C–C bond cleavage have been applied in the synthesis of valuable natural products and in the bioremediation processes. Microbial transformations of natural compounds, in which the reactions of β-oxidation cycle are used, allow the formation of natural aromatic compounds (used as food additives), pharmaceuticals and ingredients of cosmetic compositions. Using this path one can obtain methyl ketones (e.g. responsible for the characteristic smell of cheeses), γ-lactones determining the scent of several popular fruits, and vanillin. A modification of the natural steroids: saponins, alkaloids, sterols, bile acids to products useful in the synthesis of steroid drugs is the most important area of use of the enzymatic C–C bond cleavage, due to the practical significance of the products. Enzymes that catalyze the C–C bonds cleavage are important in the process of biodegradation of toxic aromatic hydrocarbons and their derivatives (bioremediation).
- Źródło:
-
Wiadomości Chemiczne; 2015, 69, 5-6; 337-368
0043-5104
2300-0295 - Pojawia się w:
- Wiadomości Chemiczne
- Dostawca treści:
- Biblioteka Nauki
Artykuł