- Tytuł:
-
Syntezy układu tiazolo[4,5-d]pirymidyny
Syntheses of the thiazolo[4,5-d]pyrimidine system - Autorzy:
- Becan, L.
- Powiązania:
- https://bibliotekanauki.pl/articles/172601.pdf
- Data publikacji:
- 2014
- Wydawca:
- Polskie Towarzystwo Chemiczne
- Tematy:
-
pochodne tiazolo[4,5-d]pirymidyny
metoda otrzymywania
synteza
synteza bicyklicznego układu
thiazolo[4,5-d]pyrimidine derivatives
synthesis
ring system
method of obtaining - Opis:
- This review is focused on the literature data about the preparation of the thiazolo[4,5-d]pyrimidine scaffold. The synthesis of this ring system has been accomplished by various methods. The synthesis can proceed via a pyrimidine onto which a thiazole ring can be annulated. The second approach involve annulation of a pyrimidine ring onto the preformed thiazole ring. Thiazolo[4,5-d]pyrimidines have been obtained by condensation of pyrimidine derivatives with thioamides [2], thionyl chloride [3], thiourea [4], bromomalononitrile [5], isothiocyanates [6] or under the influence of temperature [7]. However, most of the literature refers the methods of synthesis which begin with formation of the appropriately substituted thiazole ring. This synthetic route for preparation of fused derivatives utilizes orhtoesters [8, 9], acetic anhydride [9,10], formic acid derivatives [11, 12], carbon disulfide [13,14], appropriate isothiocyanates [15-18], urea and hydrazine derivatives [19–23], aromatic aldehydes and acid chlorides [24, 25] as key building blocks. Cyclization also occurs in high temperature or acidic reaction medium [26, 27]. The solid-phase synthesis was also described [28].
- Źródło:
-
Wiadomości Chemiczne; 2014, 68, 1-2; 95-116
0043-5104
2300-0295 - Pojawia się w:
- Wiadomości Chemiczne
- Dostawca treści:
- Biblioteka Nauki
Artykuł