- Tytuł:
-
Charakterystyka zażyciowych i pośmiertnych przemian karbamazepiny oraz wybranych rodzajów alternatywnego materiału biologicznego na potrzeby analiz toksykologiczno-sądowych
Characteristics of perimortem and postmortem transformations of carbamazepine and selected alternative biological matrices for the purpose of forensic toxicological analyses - Autorzy:
- Lendor, S.
- Powiązania:
- https://bibliotekanauki.pl/articles/171576.pdf
- Data publikacji:
- 2015
- Wydawca:
- Polskie Towarzystwo Chemiczne
- Tematy:
-
karbamazepina
metabolizm pośmiertny
alternatywne materiały biologiczne
szpik kostny
kości
carbamazepine
postmortem metabolism
alternative biological matrices
bone marrow
bones - Opis:
- This article is focused on the data concerning properties of carbamazepine, an antiepileptic drug commonly used in everyday medical practice but also frequently misused leading to many reported cases of intoxication. Due to high prevalence of this drug detailed data concerning its pharmacokinetics and prahmacodynamics can be found as well as metabolic paths that have been proven or have not been confirmed yet. For the purpose of toxicological analyses of samples collected postmortem it is also essential to know the possible transformations of an analyte due to microbial metabolism and postmortem changes of the sample matrix. In forensic cases of unavailable or unusable blood samples when advanced stage of decomposition processes in the found body occurs, alternative matrices are required. Presented review describes three types of such matrices: bones, bone marrow and grease in the context of their postmortem changes and suitability as the source of toxicological information.
- Źródło:
-
Wiadomości Chemiczne; 2015, 69, 7-8; 585-603
0043-5104
2300-0295 - Pojawia się w:
- Wiadomości Chemiczne
- Dostawca treści:
- Biblioteka Nauki
Artykuł