Temat: inhalation - Katalog OPAC zbiorów

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Tytuł:: Wybrane zagadnienia fizykochemii koloidów w procesach inhalacyjnego dostarczania leków do płuc
Selected problems of the physical chemistry of colloids in drug delivery to the lungs by inhalation
Autorzy:: Sosnowski, Tomasz R.
Dobrowolska, Katarzyna
Powiązania:: https://bibliotekanauki.pl/articles/1853731.pdf
Data publikacji:: 2021
Wydawca:: Polskie Towarzystwo Chemiczne
Tematy:: układy koloidalne
aerozol
dostarczanie leków
inhalacja
powierzchnia płuc
colloidal systems
aerosols
drug delivery
inhalation
lung surface
Opis:: The paper highlights selected problems of physical chemistry and dynamics of colloidal systems indispensable for the understanding and optimization of drug delivery by inhalation. Besides describing the fundamental aspects of aerosol flow and deposition in the respiratory system, some problems related to particle or droplet generation in the inhalers are discussed. In particular, the influence of liquid properties on aerosol formation in different nebulizers is demonstrated as a critical factor in successful aerosol therapy. The paper also addresses interactions between inhaled drug particles and bronchial mucus or the pulmonary surfactant, indicating another broad field of colloid and interface science application in medicine.
Źródło:: Wiadomości Chemiczne; 2021, 75, 9-10; 1376-1393
0043-5104
2300-0295
Pojawia się w:: Wiadomości Chemiczne
Dostawca treści:: Biblioteka Nauki

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Tytuł:: Wpływ anestetyków wziewnych na modelową błonę biologiczną
Influence of inhalation anesthetics on a model biological membrane
Autorzy:: Horochowska, Martyna
Cieślik-Boczula, Katarzyna
Rospenk, Maria
Powiązania:: https://bibliotekanauki.pl/articles/171702.pdf
Data publikacji:: 2019
Wydawca:: Polskie Towarzystwo Chemiczne
Tematy:: anestetyki wziewne
anestezja
słabe oddziaływania międzycząsteczkowe
błona lipidowa
inhalation anesthetics
anesthesia
weak intermolecular interactions
lipid membrane
Opis:: General anesthesia is defined as impairment of the central nervous system (UON) caused by intravenous or volatile anesthetics. The state of loss of consciousness or even amnesia and the disappearance of perception into external stimuli is achieved by the use of a large group of chemical compounds. The use of nitrous oxide in 1844 revolutionized surgery and medicine at that time. From that moment, anesthesiology develops dynamically, allowing more and more complex procedures. Despite more than 170 years of history of anesthesia, understanding the mechanism of reversible loss of awareness and sensitivity to pain caused by the action of general anesthetics is one of the greatest challenges of modern pharmacology and neuroscience. Incredibly high diversity of anesthetics, including both noble gases and complex steroids, combined with human sensation makes the above problem extremely difficult to solve. The reversibility of the anesthesia phenomenon suggests that the analyzed phenomenon is based on disturbance of weak intermolecular interactions, such as hydrogen bond or van der Walls forces. Anesthetic molecules may bind directly to the hydrophobic region of protein, which causes its conformational changes or disturb ion channel activity by anesthetic-induced perturbations of lipid bilayers. The mechanism of anesthesia is thus very often attributed to both protein and lipid membrane targets. The influence of anesthetic molecules on biomolecular systems can be studied successfully using many different physico-chemical methods, such as, infrared, fluorescence or nuclear magnetic resonance spectroscopy. Vibrational circular dichroism as well as differential scanning calorimetry can also be used.
Źródło:: Wiadomości Chemiczne; 2019, 73, 3-4; 263-285
0043-5104
2300-0295
Pojawia się w:: Wiadomości Chemiczne
Dostawca treści:: Biblioteka Nauki

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