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    Wyświetlanie 1-4 z 4
    Tytuł:
    Syntezy i aktywność biologiczna wybranych zasad Mannicha
    Synthesis and biological activity of selected Mannich bases
    Autorzy:
    Nawrocka, W. P.
    Nowicka, A.
    Powiązania:
    https://bibliotekanauki.pl/articles/172259.pdf
    Data publikacji:
    2014
    Wydawca:
    Polskie Towarzystwo Chemiczne
    Tematy:
    zasada Mannicha
    aktywność biologiczna
    syntezy
    Mannich bases
    biological activity
    synthesis
    Opis:
    The Mannich reaction is important for the synthesis and modification of biologically active compounds. Mannich bases – substituted products containing different heterocyclic system in their structures seem to be suitable candidates for further chemical modifications and might be of interest as pharmacologically active compounds. The main goal of this article is to present synthesis and biological activity of selected Mannich bases. Based on a review of the chemical literature, Mannich bases showed a multipharmacological effects. The Mannich bases, containing various heterocyclic systems were identified as potent anticancer agents. Presented compounds exhibit cytotoxic, antiproliferate in vitro, anticonvulsant, antioxidative, antiinflaminatory and analgesic activity. Some of them can be used in a treatment of diabetes and hypertension.
    Źródło:
    Wiadomości Chemiczne; 2014, 68, 11-12; 981-1008
    0043-5104
    2300-0295
    Pojawia się w:
    Wiadomości Chemiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Synteza i redukcja prochiralnych imin
    Synthesis and reduction of prochiral imines
    Autorzy:
    Berniak, T. A.
    Powiązania:
    https://bibliotekanauki.pl/articles/172255.pdf
    Data publikacji:
    2016
    Wydawca:
    Polskie Towarzystwo Chemiczne
    Tematy:
    ketiminy
    gossypol
    aldiminy
    zasady Schiffa
    oksymy
    ketimines
    aldimines
    Schiff bases
    oximes
    Opis:
    Natural chemical compounds and their derivatives could be used for designing new classes of anticancer, antifungal or antiviral drugs. One of those compounds is gossypol, isolated from grains of wool. Gossypol’s derivatives can freely penetrate the blood-brain barrier (BBB). This basic review considers synthesis and reduction of prochiral imines. Gossypol derivatives belong to imines. Imines as unstable compounds, hydrolyze in contact with a small amount of water. There are substrates for preparation of oximes and its derivatives. In this article three methods of imines production are presented. There are: (a) reaction of aldehyde or ketones with primary amine, (b) addition of Grignard reagents to nitriles and (c) pyrolysis of alkyl azide. The first one is discussed in details with specific description of the mechanism of both steps: first stage - addition to form a hemiaminal, second one – dehydration with formation of imine. Many conditions such as acid power, value of pH reaction and environment (preferably anhydrous) have influence on the formation rate of imines and determine each of two stages, i.e. addition and dehydration. Furthermore, the imines-enamines tautomeric and stereochemical aspects with possible attack of nucleophile molecules to the carbon atom of the C=N bond from the Si or Re side of prochiral imines as well as potential ways of imines reductions to amines by using commonly used reducers (NaCNBH3) are discussed. Moreover, two new methods of reduction are presented: the first – with using trichlor acids catalyzed chiral Lewis’s bases and the second one – asymmetric hydrogenation of imines.
    Źródło:
    Wiadomości Chemiczne; 2016, 70, 5-6; 353-368
    0043-5104
    2300-0295
    Pojawia się w:
    Wiadomości Chemiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Syntezy wybranych zasad Mannicha o aktywności przeciwbakteryjnej i przeciwgrzybiczej in vitro
    Synthesis and antibacterial and antifungal activity in vitro of selected Mannich bases
    Autorzy:
    Nowicka, A.
    Liszkiewicz, H.
    Nawrocka, W. P.
    Powiązania:
    https://bibliotekanauki.pl/articles/172209.pdf
    Data publikacji:
    2014
    Wydawca:
    Polskie Towarzystwo Chemiczne
    Tematy:
    zasada Mannicha
    aktywność przeciwbakteryjna
    aktywność przeciwgrzybicza
    Mannich bases
    antibacterial activity
    antifungal activity
    Opis:
    The Mannich reaction is a three-component condensation reaction involving an active hydrogen containing compound, formaldehyde and a primary or a secondary amine. The Mannich reaction is one of the most important basic reaction types in organic chemistry. This kind of aminoalkylation is important for the synthesis and modification of biologically active compounds. Many studies have shown that Mannich bases possesses potent biological activities: antibacterial, antifungal, anti-inflammatory and antimalarial properties. Mannich bases – substituted products containing different heterocyclic moiety in their structures seem to be suitable candidates for further chemical modifications and might be of interest as pharmacologically active compounds. The main goal of this article is to present synthesis and antimicrobial activity of selected Mannich bases. The Mannich reaction is known to be very useful for the synthesis of antibacterial compounds. The Mannich bases, containing various heterocyclic systems were identified as potent antimicrobial agents. Obtained in Mannich reaction derivatives of antibacterial drugs: ciprofloxacine, norfloxacine demonstrate higher antibacterial activity than used drugs, while derivatives of drugs: ibuporofen or phenytoine changed the profile of action of new synthesized compounds.
    Źródło:
    Wiadomości Chemiczne; 2014, 68, 3-4; 161-186
    0043-5104
    2300-0295
    Pojawia się w:
    Wiadomości Chemiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Zasady Schiffa : wybrane syntezy, reakcje i aktywność biologiczna
    Schiff bases : selected syntheses, reactions and biological activity
    Autorzy:
    Nowicka, A.
    Liszkiewicz, H.
    Nawrocka, W. P.
    Powiązania:
    https://bibliotekanauki.pl/articles/172082.pdf
    Data publikacji:
    2014
    Wydawca:
    Polskie Towarzystwo Chemiczne
    Tematy:
    zasada Schiffa
    iminy
    aktywność biologiczna
    synteza
    struktura
    Schiff bases
    imines
    biological activity
    synthesis
    structure
    Opis:
    Schiff bases are compounds with a functional group that contains a carbon- -nitrogen double bond with the nitrogen atom connected to an aryl or alkyl group. Schiff bases are condensation products of primary amines with carbonyl compound. Several studies showed that the presence of a lone pair of electrons on the nitrogen atom of the azomethine determine biological and chemical properties of imines. Schiff bases are generally excellent chelating agents, because of the special properties of C=N bond. Their metal complexes have been widely studied because they possess anticancer in vitro and herbicidal applications. Imines also have biological importance. Schiff bases are common enzymatic intermediates where an amine reacts with an aldehyde or ketone of a cofactor or a substrate. Imines have been reported for their biological properties such as antibacterial (E. coli, S. aureus), antifungal (C. albicans) activities. A large number of different Schiff bases are active against a wide range of protozoan (T. gypseum, P. viticola).
    Źródło:
    Wiadomości Chemiczne; 2014, 68, 3-4; 187-209
    0043-5104
    2300-0295
    Pojawia się w:
    Wiadomości Chemiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-4 z 4

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