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Wyświetlanie 1-5 z 5
Tytuł:
Syntezy wybranych zasad Mannicha o aktywności przeciwbakteryjnej i przeciwgrzybiczej in vitro
Synthesis and antibacterial and antifungal activity in vitro of selected Mannich bases
Autorzy:
Nowicka, A.
Liszkiewicz, H.
Nawrocka, W. P.
Powiązania:
https://bibliotekanauki.pl/articles/172209.pdf
Data publikacji:
2014
Wydawca:
Polskie Towarzystwo Chemiczne
Tematy:
zasada Mannicha
aktywność przeciwbakteryjna
aktywność przeciwgrzybicza
Mannich bases
antibacterial activity
antifungal activity
Opis:
The Mannich reaction is a three-component condensation reaction involving an active hydrogen containing compound, formaldehyde and a primary or a secondary amine. The Mannich reaction is one of the most important basic reaction types in organic chemistry. This kind of aminoalkylation is important for the synthesis and modification of biologically active compounds. Many studies have shown that Mannich bases possesses potent biological activities: antibacterial, antifungal, anti-inflammatory and antimalarial properties. Mannich bases – substituted products containing different heterocyclic moiety in their structures seem to be suitable candidates for further chemical modifications and might be of interest as pharmacologically active compounds. The main goal of this article is to present synthesis and antimicrobial activity of selected Mannich bases. The Mannich reaction is known to be very useful for the synthesis of antibacterial compounds. The Mannich bases, containing various heterocyclic systems were identified as potent antimicrobial agents. Obtained in Mannich reaction derivatives of antibacterial drugs: ciprofloxacine, norfloxacine demonstrate higher antibacterial activity than used drugs, while derivatives of drugs: ibuporofen or phenytoine changed the profile of action of new synthesized compounds.
Źródło:
Wiadomości Chemiczne; 2014, 68, 3-4; 161-186
0043-5104
2300-0295
Pojawia się w:
Wiadomości Chemiczne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Właściwości antyoksydacyjne, antybakteryjne i przeciwgrzybicze związków kompleksowych miedzi(II)
Antioxidant, antibacterial and antifungal properties of complex compounds of copper(II)
Autorzy:
Piotrowska, A.
Drzeżdżon, J.
Jacewicz, D.
Chmurzyński, L.
Powiązania:
https://bibliotekanauki.pl/articles/171722.pdf
Data publikacji:
2017
Wydawca:
Polskie Towarzystwo Chemiczne
Tematy:
związki kompleksowe
miedź(II)
antyoksydanty
aktywność antybakteryjna
aktywność przeciwgrzybicza
copper(II) complexes
antioxidants
antibacterial activity
antifungal activity
Opis:
Since late 1930s copper has been recognized as an essential trace metal in living organisms. Copper(II) cation plays the role as a coordination center not only in the single-nuclear complexes, but also in the multinuclear coordination compounds with a particular emphasis on the polymers as ligands. The selected complex compounds of copper(II) with ligands which are organic and inorganic species have been characterized taking into account their physico-chemical properties. In addition, the complex compounds containing ligands such as Schiff ’s bases, hydrocarbons, organic bases, and also polycarboxylic anions: oxydiacetate, thiodiacetate, iminodiacetate and dipicolinate have been described considering their role in the biological systems. Nowadays tested coordination compounds of copper(II) have interesting antibacterial activities against bacteria strains that are antagonistic to the human. The antibacterial activity of copper(II) complex is stronger than some of the known antibacterial substances e.g. ciprofloxacin. In addition, copper(II) complex compounds exhibit a 64-fold greater antimicrobial properties than copper(II) chloride. Moreover, these compounds have antifungal and antioxidant properties. The activities of antibacterial, antifungal, and antioxidant complex compounds of copper( II) have been compared to the reactivities of these compounds with complexes used as reference substances, e.g. L-ascorbic acid, in the assay using nitrotetrazolium blue.
Źródło:
Wiadomości Chemiczne; 2017, 71, 3-4; 219-240
0043-5104
2300-0295
Pojawia się w:
Wiadomości Chemiczne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Synteza i aktywność biologiczna pochodnych salinomycyny
Synthesis and biological activity of salinomycin derivatives
Autorzy:
Antoszczak, M.
Huczyński, A.
Brzezinski, B.
Powiązania:
https://bibliotekanauki.pl/articles/171728.pdf
Data publikacji:
2017
Wydawca:
Polskie Towarzystwo Chemiczne
Tematy:
antybiotyki jonoforowe
jonofory
struktura molekularna
aktywność przeciwbakteryjna
aktywność przeciwnowotworowa
ionophore antibiotics
ionophores
molecular structure
antibacterial activity
anticancer activity
Opis:
Polyether ionophore antibiotics (ionophores) represent a large group of naturally- occurring lipid-soluble compounds isolated from actinomycetes strains of Streptomyces genus. Ionophores are able to form complexes with the metal cations, especially sodium and potassium, and transport them across the lipid membranes according to electroneutral or electrogenic transport mechanism. This process disturbs the intercellular Na+/K+ concentration gradient and intracellular pH, leads to the mitochondrial injuries, cell swelling, vacuolization and finally to programmed cell death (apoptosis). For this reason, ionophore antibiotics found commercial use in veterinary medicine as coccidiostatic agents and non-hormonal growth promoters. In addition to the industrial use of ionophores, some of them effectively and selectively inhibit properties of different cancer cells as well as enhance the anti-cancer effects of radio- and/or chemotherapy. In this group, particularly interesting is salinomycin because of its potent anti-microbial and anti-cancer activity, including efficiency against multi-drug resistant cancer cells and cancer stem cells. A very interesting direction of research is the chemical modification of ionophore antibiotics, which can lead to obtaining various derivatives with better biological activity and lower toxicity than those of the starting substances. Because biological activity of ionophore antibiotics and their derivatives is strictly connected with the ability to form characteristic pseudocyclic structures around the complexed cations (host-guest complex), it is also important to establish the detailed information on these structures. In this context, our review article is focused on the possible role of salinomycin and its derivatives in anti-microbial as well as anti-cancer therapy, and gives an overview of the properties of this antibiotic.
Źródło:
Wiadomości Chemiczne; 2017, 71, 7-8; 629-661
0043-5104
2300-0295
Pojawia się w:
Wiadomości Chemiczne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Pochodne 1,2,3-triazolu. Potencjalne leki?
Derivatives of 1,2,3-triazole. Potential drugs?
Autorzy:
Bankowska, E.
Wróblewski, A. E.
Powiązania:
https://bibliotekanauki.pl/articles/171634.pdf
Data publikacji:
2012
Wydawca:
Polskie Towarzystwo Chemiczne
Tematy:
pochodne 1,2,3-triazolu
aktywność przeciwbakteryjna
aktywność przeciwgrzybicza
aktywność przeciwgruźlicza
aktywność przeciwpsychotyczna
aktywność przeciwdrgawkowa
aktywność przeciwzapalna
aktywność hipoglikemiczna
aktywność przeciwnowotworowa
aktywność przeciwwirusowa
1,2,3-triazole derivatives
antibacterial activity
antifungal activity
antitubercular activity
antipsychotic activity
anticonvulsant activity
anti-inflammatory activity
hypoglycemic activity
anticancer activity
antiviral activity
Opis:
Recently, 1,2,3-triazoles have gained an increased attention in the field of drug discovery because several derivatives have already been marketed as medications (e.g. tazobactam, cefatrizine, rufinamide) [1, 2] and many of them appeared to be very active in diverse biological studies including plinambulin 69 currently in the last stage of the clinical trials [60]. In this review very recent investigations of antibacterial, antitubercular, antifungal, antipsychotic, antiepileptic, anti-inflammatory, hypoglycemic, anticancer and antiviral properties of 1,2,3-triazole derivatives are discussed. These studies allowed to select several compounds which were found to be more active in comparison to the already used drugs.
Źródło:
Wiadomości Chemiczne; 2012, 66, 11-12; 993-1022
0043-5104
2300-0295
Pojawia się w:
Wiadomości Chemiczne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Biokoniugaty antybiotykow jonoforowych : cele, strategie syntezy i właściwości
Bioconjugates of ionophore antibiotics : goals, synthesis strategies and properties
Autorzy:
Antoszczak, M.
Kordylas, M.
Huczyński, A.
Powiązania:
https://bibliotekanauki.pl/articles/172178.pdf
Data publikacji:
2018
Wydawca:
Polskie Towarzystwo Chemiczne
Tematy:
antybiotyki jonoforowe
jonofory
biokoniugacja
hybrydy
aktywność przeciwbakteryjna
aktywność przeciwnowotworowa
ionophore antibiotics
ionophores
bioconjugation
hybrids
antibacterial
activity
anticancer activity
Opis:
Polyether ionophore antibiotics (ionophores) represent a large group of naturally- occurring lipophilic compounds which are able to form complexes with the metal cations and transport them across the lipid membranes. This process disturbs the intercellular Na+/K+ concentration gradient and intracellular pH, and leads to the mitochondrial damages, cell swelling, vacuolization and finally to apoptosis process. For this reason, ionophores are commonly used in veterinary medicine as the non-hormonal growth-promoting as well as coccidiostatic agents. In this group particularly interesting are monensin and salinomycin (Fig. 1) because of their proved anti-tumour activity, including efficiency against multidrug- -resistant cancer cells and cancer stem cells of different origin. Improved synthetic derivatives of both polyether ionophores are thus of considerable current interest. Selective derivatization of these structures whose display multiple reactive functional groups and, in the case of salinomycin, a sensitive tricyclic spiroketal ring system is however non-trivial. Even so, semi-synthetic analogs reported to date includes i.a. selective derivatization of the carboxyl group, the three hydroxyl groups, the ketone group, the alkene, and epimerization of the characteristic tricyclic salinomycin unit (for more details see: M. Antoszczak, A. Huczyński, B. Brzezinski, Wiad. Chem., 2017, 71, 629). On the other hand, as part of the original program to develop innovatory anti- -cancer pro-drugs and prompted by the idea that cancer cells may be individually effectively killed by monensin and salinomycin, a very interesting direction of research is bioconjugation of these ionophores. In this context, our review article is focused on the possible role of hybrids of both ionophore antibiotics with other biologically active substances (natural amino acids, Cinchona alkaloids, flavonoids, nucleosides) in anti-bacterial and anti-cancer treatment, and gives an overview of their properties.
Źródło:
Wiadomości Chemiczne; 2018, 72, 1-2; 1-28
0043-5104
2300-0295
Pojawia się w:
Wiadomości Chemiczne
Dostawca treści:
Biblioteka Nauki
Artykuł
    Wyświetlanie 1-5 z 5

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