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    Tytuł:
    Syntezy wybranych zasad Mannicha o aktywności przeciwbakteryjnej i przeciwgrzybiczej in vitro
    Synthesis and antibacterial and antifungal activity in vitro of selected Mannich bases
    Autorzy:
    Nowicka, A.
    Liszkiewicz, H.
    Nawrocka, W. P.
    Powiązania:
    https://bibliotekanauki.pl/articles/172209.pdf
    Data publikacji:
    2014
    Wydawca:
    Polskie Towarzystwo Chemiczne
    Tematy:
    zasada Mannicha
    aktywność przeciwbakteryjna
    aktywność przeciwgrzybicza
    Mannich bases
    antibacterial activity
    antifungal activity
    Opis:
    The Mannich reaction is a three-component condensation reaction involving an active hydrogen containing compound, formaldehyde and a primary or a secondary amine. The Mannich reaction is one of the most important basic reaction types in organic chemistry. This kind of aminoalkylation is important for the synthesis and modification of biologically active compounds. Many studies have shown that Mannich bases possesses potent biological activities: antibacterial, antifungal, anti-inflammatory and antimalarial properties. Mannich bases – substituted products containing different heterocyclic moiety in their structures seem to be suitable candidates for further chemical modifications and might be of interest as pharmacologically active compounds. The main goal of this article is to present synthesis and antimicrobial activity of selected Mannich bases. The Mannich reaction is known to be very useful for the synthesis of antibacterial compounds. The Mannich bases, containing various heterocyclic systems were identified as potent antimicrobial agents. Obtained in Mannich reaction derivatives of antibacterial drugs: ciprofloxacine, norfloxacine demonstrate higher antibacterial activity than used drugs, while derivatives of drugs: ibuporofen or phenytoine changed the profile of action of new synthesized compounds.
    Źródło:
    Wiadomości Chemiczne; 2014, 68, 3-4; 161-186
    0043-5104
    2300-0295
    Pojawia się w:
    Wiadomości Chemiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Właściwości antyoksydacyjne, antybakteryjne i przeciwgrzybicze związków kompleksowych miedzi(II)
    Antioxidant, antibacterial and antifungal properties of complex compounds of copper(II)
    Autorzy:
    Piotrowska, A.
    Drzeżdżon, J.
    Jacewicz, D.
    Chmurzyński, L.
    Powiązania:
    https://bibliotekanauki.pl/articles/171722.pdf
    Data publikacji:
    2017
    Wydawca:
    Polskie Towarzystwo Chemiczne
    Tematy:
    związki kompleksowe
    miedź(II)
    antyoksydanty
    aktywność antybakteryjna
    aktywność przeciwgrzybicza
    copper(II) complexes
    antioxidants
    antibacterial activity
    antifungal activity
    Opis:
    Since late 1930s copper has been recognized as an essential trace metal in living organisms. Copper(II) cation plays the role as a coordination center not only in the single-nuclear complexes, but also in the multinuclear coordination compounds with a particular emphasis on the polymers as ligands. The selected complex compounds of copper(II) with ligands which are organic and inorganic species have been characterized taking into account their physico-chemical properties. In addition, the complex compounds containing ligands such as Schiff ’s bases, hydrocarbons, organic bases, and also polycarboxylic anions: oxydiacetate, thiodiacetate, iminodiacetate and dipicolinate have been described considering their role in the biological systems. Nowadays tested coordination compounds of copper(II) have interesting antibacterial activities against bacteria strains that are antagonistic to the human. The antibacterial activity of copper(II) complex is stronger than some of the known antibacterial substances e.g. ciprofloxacin. In addition, copper(II) complex compounds exhibit a 64-fold greater antimicrobial properties than copper(II) chloride. Moreover, these compounds have antifungal and antioxidant properties. The activities of antibacterial, antifungal, and antioxidant complex compounds of copper( II) have been compared to the reactivities of these compounds with complexes used as reference substances, e.g. L-ascorbic acid, in the assay using nitrotetrazolium blue.
    Źródło:
    Wiadomości Chemiczne; 2017, 71, 3-4; 219-240
    0043-5104
    2300-0295
    Pojawia się w:
    Wiadomości Chemiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Synteza i aktywność biologiczna pochodnych salinomycyny
    Synthesis and biological activity of salinomycin derivatives
    Autorzy:
    Antoszczak, M.
    Huczyński, A.
    Brzezinski, B.
    Powiązania:
    https://bibliotekanauki.pl/articles/171728.pdf
    Data publikacji:
    2017
    Wydawca:
    Polskie Towarzystwo Chemiczne
    Tematy:
    antybiotyki jonoforowe
    jonofory
    struktura molekularna
    aktywność przeciwbakteryjna
    aktywność przeciwnowotworowa
    ionophore antibiotics
    ionophores
    molecular structure
    antibacterial activity
    anticancer activity
    Opis:
    Polyether ionophore antibiotics (ionophores) represent a large group of naturally- occurring lipid-soluble compounds isolated from actinomycetes strains of Streptomyces genus. Ionophores are able to form complexes with the metal cations, especially sodium and potassium, and transport them across the lipid membranes according to electroneutral or electrogenic transport mechanism. This process disturbs the intercellular Na+/K+ concentration gradient and intracellular pH, leads to the mitochondrial injuries, cell swelling, vacuolization and finally to programmed cell death (apoptosis). For this reason, ionophore antibiotics found commercial use in veterinary medicine as coccidiostatic agents and non-hormonal growth promoters. In addition to the industrial use of ionophores, some of them effectively and selectively inhibit properties of different cancer cells as well as enhance the anti-cancer effects of radio- and/or chemotherapy. In this group, particularly interesting is salinomycin because of its potent anti-microbial and anti-cancer activity, including efficiency against multi-drug resistant cancer cells and cancer stem cells. A very interesting direction of research is the chemical modification of ionophore antibiotics, which can lead to obtaining various derivatives with better biological activity and lower toxicity than those of the starting substances. Because biological activity of ionophore antibiotics and their derivatives is strictly connected with the ability to form characteristic pseudocyclic structures around the complexed cations (host-guest complex), it is also important to establish the detailed information on these structures. In this context, our review article is focused on the possible role of salinomycin and its derivatives in anti-microbial as well as anti-cancer therapy, and gives an overview of the properties of this antibiotic.
    Źródło:
    Wiadomości Chemiczne; 2017, 71, 7-8; 629-661
    0043-5104
    2300-0295
    Pojawia się w:
    Wiadomości Chemiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Pochodne 1,2,3-triazolu. Potencjalne leki?
    Derivatives of 1,2,3-triazole. Potential drugs?
    Autorzy:
    Bankowska, E.
    Wróblewski, A. E.
    Powiązania:
    https://bibliotekanauki.pl/articles/171634.pdf
    Data publikacji:
    2012
    Wydawca:
    Polskie Towarzystwo Chemiczne
    Tematy:
    pochodne 1,2,3-triazolu
    aktywność przeciwbakteryjna
    aktywność przeciwgrzybicza
    aktywność przeciwgruźlicza
    aktywność przeciwpsychotyczna
    aktywność przeciwdrgawkowa
    aktywność przeciwzapalna
    aktywność hipoglikemiczna
    aktywność przeciwnowotworowa
    aktywność przeciwwirusowa
    1,2,3-triazole derivatives
    antibacterial activity
    antifungal activity
    antitubercular activity
    antipsychotic activity
    anticonvulsant activity
    anti-inflammatory activity
    hypoglycemic activity
    anticancer activity
    antiviral activity
    Opis:
    Recently, 1,2,3-triazoles have gained an increased attention in the field of drug discovery because several derivatives have already been marketed as medications (e.g. tazobactam, cefatrizine, rufinamide) [1, 2] and many of them appeared to be very active in diverse biological studies including plinambulin 69 currently in the last stage of the clinical trials [60]. In this review very recent investigations of antibacterial, antitubercular, antifungal, antipsychotic, antiepileptic, anti-inflammatory, hypoglycemic, anticancer and antiviral properties of 1,2,3-triazole derivatives are discussed. These studies allowed to select several compounds which were found to be more active in comparison to the already used drugs.
    Źródło:
    Wiadomości Chemiczne; 2012, 66, 11-12; 993-1022
    0043-5104
    2300-0295
    Pojawia się w:
    Wiadomości Chemiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Biokoniugaty antybiotykow jonoforowych : cele, strategie syntezy i właściwości
    Bioconjugates of ionophore antibiotics : goals, synthesis strategies and properties
    Autorzy:
    Antoszczak, M.
    Kordylas, M.
    Huczyński, A.
    Powiązania:
    https://bibliotekanauki.pl/articles/172178.pdf
    Data publikacji:
    2018
    Wydawca:
    Polskie Towarzystwo Chemiczne
    Tematy:
    antybiotyki jonoforowe
    jonofory
    biokoniugacja
    hybrydy
    aktywność przeciwbakteryjna
    aktywność przeciwnowotworowa
    ionophore antibiotics
    ionophores
    bioconjugation
    hybrids
    antibacterial
    activity
    anticancer activity
    Opis:
    Polyether ionophore antibiotics (ionophores) represent a large group of naturally- occurring lipophilic compounds which are able to form complexes with the metal cations and transport them across the lipid membranes. This process disturbs the intercellular Na+/K+ concentration gradient and intracellular pH, and leads to the mitochondrial damages, cell swelling, vacuolization and finally to apoptosis process. For this reason, ionophores are commonly used in veterinary medicine as the non-hormonal growth-promoting as well as coccidiostatic agents. In this group particularly interesting are monensin and salinomycin (Fig. 1) because of their proved anti-tumour activity, including efficiency against multidrug- -resistant cancer cells and cancer stem cells of different origin. Improved synthetic derivatives of both polyether ionophores are thus of considerable current interest. Selective derivatization of these structures whose display multiple reactive functional groups and, in the case of salinomycin, a sensitive tricyclic spiroketal ring system is however non-trivial. Even so, semi-synthetic analogs reported to date includes i.a. selective derivatization of the carboxyl group, the three hydroxyl groups, the ketone group, the alkene, and epimerization of the characteristic tricyclic salinomycin unit (for more details see: M. Antoszczak, A. Huczyński, B. Brzezinski, Wiad. Chem., 2017, 71, 629). On the other hand, as part of the original program to develop innovatory anti- -cancer pro-drugs and prompted by the idea that cancer cells may be individually effectively killed by monensin and salinomycin, a very interesting direction of research is bioconjugation of these ionophores. In this context, our review article is focused on the possible role of hybrids of both ionophore antibiotics with other biologically active substances (natural amino acids, Cinchona alkaloids, flavonoids, nucleosides) in anti-bacterial and anti-cancer treatment, and gives an overview of their properties.
    Źródło:
    Wiadomości Chemiczne; 2018, 72, 1-2; 1-28
    0043-5104
    2300-0295
    Pojawia się w:
    Wiadomości Chemiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-5 z 5

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