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    Wyświetlanie 1-11 z 11
    Tytuł:
    Syntezy wybranych leków pochodnych 2-amino-1H-benzimidazolu
    Synthesis of Selected drugs 2-amino-1H-benzimidazole derivatives
    Autorzy:
    Nowicka, A.
    Nawrocka, W. P.
    Powiązania:
    https://bibliotekanauki.pl/articles/172049.pdf
    Data publikacji:
    2013
    Wydawca:
    Polskie Towarzystwo Chemiczne
    Tematy:
    synteza leków
    leki przeciwrobacze
    leki przeciwhistaminowe
    leki przeciwwirusowe
    leki przeciwnowotworowe
    Opis:
    2-Amino-1H-benzimidazole fragment occurs in broad spectrum of drugs with anticancer, antiviral, antifungal, anthelmintic and antihistamine properties. There are 30 drugs, 2-amino-1H-benzimidazole derivatives, registered in the world. Mebendazole, Albendazole and another derivatives are antihelmintic drugs which are believed to work by selectively inhibiting the synthesis of microtubules in parasitic worms, and by destroying extant cytoplasmic microtubes in their intestinal [9, 12, 14]. Astemizole was a second-generation antihistamine drug that has a long duration of action. It has been withdrawn from the market in most countries because of rare but potentially fatal side effects [19]. Mizolastine is non-sedating antihistamine drug [21]. It blocks H1 receptors and doesn’t prevent the actual release of histamine from mast cells, but just prevents it binding to receptors. Enviroksim and its isomer Zinviroksim and Enviraden are antivirial drugs [26, 27]. They inhibit multiplication of 15 different serotypes of rhinovirus. Benomyl is a systemic fungicide that is selectively toxic to microorganisms [29]. Benomyl binds to microtubules, interfering with cell functions, such as meiosis and intracellular transportation. Carbendazim is a widely used, broad-spectrum fungicide and a metabolite of Benomyl [29]. It’s also shown an anticancer activity. Oncodazole shows antifungal, antineoplastic and antihelmintic activities, which exerts its effect in cells by binding to tubulin and interfering with the polymerization of microtubules [33].
    Źródło:
    Wiadomości Chemiczne; 2013, 67, 7-8; 695-714
    0043-5104
    2300-0295
    Pojawia się w:
    Wiadomości Chemiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Syntezy wybranych, nowych pochodnych 2-amino-1H-benzimidazolu i ich mechanizmy działania biologicznego
    Synthesis of Selected, New 2-amino-1H-benzimidazole derivatives and Their mechanism of biological activity
    Autorzy:
    Nowicka, A.
    Nawrocka, W. P.
    Powiązania:
    https://bibliotekanauki.pl/articles/172102.pdf
    Data publikacji:
    2013
    Wydawca:
    Polskie Towarzystwo Chemiczne
    Tematy:
    pochodne 2-amino-1H-benzimidazolu
    syntezy
    aktywność biologiczna
    2-amino-1H-benzimidazole derivatives
    synthesis
    biological activity
    Opis:
    Many 2-amino-1H-benzimidazole drugs such as antihistaminic mizolastine and norastemizole or antiparasitic mebendazole, albendazole and thiabendazole have been used in clinic [1, 2]. Benomyl and its metabolite Carbendazim are both antifungal and anticancer drugs [4]. Recently, a lot of literature has revealed that 2-amino-1H-benzimidazole derivatives could effectively inhibit the growth of various microorganisms, what suggests that 2-aminobenzimidazole compounds should have large potential as a new type of antibacterial [15] and antifungal [18] agents. A number of 2-aminobenzimidazoles have exhibited antiproliferative in vitro properties [11]. Some new compounds, containing in theirs structures 2-aminobenzimidazole, show interesting and diverse cytotoxic mechanism of action, e.g. induce apoptosis of cancer cells [13]. Some of 2-aminobenzimidazole analogues are histamine and serotonin receptors antagonists [32]. 2-Aminobenzimidazoles derivatives have been frequently found to display a variety of biological activities like anti-inflammatory, antioxidant and anticoagulant [32] properties.
    Źródło:
    Wiadomości Chemiczne; 2013, 67, 3-4; 203-225
    0043-5104
    2300-0295
    Pojawia się w:
    Wiadomości Chemiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Syntezy i aktywność biologiczna wybranych zasad Mannicha
    Synthesis and biological activity of selected Mannich bases
    Autorzy:
    Nawrocka, W. P.
    Nowicka, A.
    Powiązania:
    https://bibliotekanauki.pl/articles/172259.pdf
    Data publikacji:
    2014
    Wydawca:
    Polskie Towarzystwo Chemiczne
    Tematy:
    zasada Mannicha
    aktywność biologiczna
    syntezy
    Mannich bases
    biological activity
    synthesis
    Opis:
    The Mannich reaction is important for the synthesis and modification of biologically active compounds. Mannich bases – substituted products containing different heterocyclic system in their structures seem to be suitable candidates for further chemical modifications and might be of interest as pharmacologically active compounds. The main goal of this article is to present synthesis and biological activity of selected Mannich bases. Based on a review of the chemical literature, Mannich bases showed a multipharmacological effects. The Mannich bases, containing various heterocyclic systems were identified as potent anticancer agents. Presented compounds exhibit cytotoxic, antiproliferate in vitro, anticonvulsant, antioxidative, antiinflaminatory and analgesic activity. Some of them can be used in a treatment of diabetes and hypertension.
    Źródło:
    Wiadomości Chemiczne; 2014, 68, 11-12; 981-1008
    0043-5104
    2300-0295
    Pojawia się w:
    Wiadomości Chemiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Syntezy i aktywność biologiczna pochodnych pirydopirydazyny
    Synthesis and biological activity of pyridopyridazine derivatives
    Autorzy:
    Nawrocka, W. P.
    Nowicka, A.
    Powiązania:
    https://bibliotekanauki.pl/articles/171526.pdf
    Data publikacji:
    2014
    Wydawca:
    Polskie Towarzystwo Chemiczne
    Tematy:
    pochodne pirydopirydazyn
    struktury
    syntezy
    aktywność biologiczna
    pyridopyridazine derivatives
    structures
    syntheses
    biological activity
    Opis:
    For many years all six isomers of pyridopyridazines have been an interesting class of heterocyclic compounds because of their biological and chemical properties. Endralazine is a hypotensive drug, which contain pyrido[4,3-c]pyridazine structure. Presented in this paper selected compounds exhibit antiviral [20] and antibacterial [21, 22] activity. Based on review of the chemical literature, derivatives of pyridopyridazine showed a multipharmacological effects such as analgesic [23–29] and diuretic [33–38] activity. Some chemical compounds, containing pyridopyridazine moiety showed anticancer activity in vitro with different mechanism of action [12, 15, 18, 19]. Novel pyrazolopyridopyridazine derivatives have been identified as more potent and selective phosphodiesterase 5 (PDE5) inhibitors than sildenafil [41]. Pyrido[2,3-d] pyridazine derivatives were synthesized as selective PDE4 inhibitors [44–46], with good selectivity profile and less undesiderable side effects. 2,3,8-Trisubstituted pyrido[ 2,3-d]pyridazines were novel classes of GABA-A receptor benzodiazepine binding site ligands [30, 31]. While pyrido[2,3-c]pyridazine derivatives were selective agonists for the benzodiazepine site of GABA-A receptor [32]. Some of new substituted pyrido[3,2-c]pyridazine derivatives possess molluscicidal activity [54] and can be used as biodegradable agrochemicals.
    Źródło:
    Wiadomości Chemiczne; 2014, 68, 1-2; 67-94
    0043-5104
    2300-0295
    Pojawia się w:
    Wiadomości Chemiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Wybrane Metody syntezy 2-amino-1H-benzimidazolu
    Selected Methods of the Synthesis of 2-amino-1H-benzimidazole
    Autorzy:
    Nawrocka, W. P.
    Nowicka, A.
    Powiązania:
    https://bibliotekanauki.pl/articles/172251.pdf
    Data publikacji:
    2013
    Wydawca:
    Polskie Towarzystwo Chemiczne
    Tematy:
    2-amino-1H-benzimidazol
    alkilo i arylo pochodne
    syntezy
    2-amino-1H-benzimidazole
    alkyl and aryl derivatives
    synthesis
    Opis:
    2-Amino-1H-benzimidazoles have attracted much attention due to their varied biological activities toward numerous diseases. 2-Amino-1H-benzimidazole core structures can be found in commercial drugs such as astemizole, mizolastine or carbendazime [1, 2]. 2-(N-substituted)-aminobenzimidazoles are widely used chemical substances in medicinal chemistry. Several compounds from this class have been used as anticancer, antihistamine and antiviral agents [3–5]. An efficient practical method for the synthesis of a diverse collection of 2-aminobenzimidazoles would be of great value for drug discovery. Several synthetic methods have been reported in the literature for the synthesis of 2-aminobenzimidazoles [11]. The synthesis of 2-aminobenzimidazole may be carried out in several ways. The most popular and economical method involves the treatment of various 2-substituted anilines with different cyclising agents to yield 2-aminobenzimidazoles. The cyclocondensation of an appropriate o-phenylenediamine with cyanogen bromide affords high yields of 2-aminobenzimidazoles [12]. Hydrogenation of o-cyanaminonitrobenzene over Raney nickel catalyst gives 2-aminobenzimidazole [34, 35]. Substituted 2-aminobenimidazoles have also been prepared by oxidation of the corresponding substituted thioureas with isothiocyanates using desulfurizing agents such as mercury-(II) oxide or methyl iodide [18–21].
    Źródło:
    Wiadomości Chemiczne; 2013, 67, 7-8; 715-732
    0043-5104
    2300-0295
    Pojawia się w:
    Wiadomości Chemiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Aktywność biologiczna pochodnych 2-amino -1H-benzimidazolu. Część II
    Biological activity of 2-amino -1Hbenzimidazole derivatives. Part II
    Autorzy:
    Nawrocka, W. P.
    Nowicka, A.
    Liszkiewicz, H.
    Powiązania:
    https://bibliotekanauki.pl/articles/171652.pdf
    Data publikacji:
    2012
    Wydawca:
    Polskie Towarzystwo Chemiczne
    Tematy:
    pochodne 2-aminobenzimidazolu
    aktywność biologiczna
    2-aminobenzimidazole derivatives
    biological activity
    Opis:
    2-Aminobenzimidazole occur in a broad spectrum of drugs and pharmacological agents with hypotensive [26], antihistaminic, immunotropic [16], antiarrhythmic [25], analgesic [21, 22] or antiaggregatory properties [27]. There are 30 drugs, 2-aminobenzimidazole derivatives, registered in the world which exhibit diverse pharmacological activities. Carbendazim is an antifungal drug, but in 2003 it has been registered as anticancer [1]. They are also voltage sensitive calcium channel blockers [33], inhibitors of vascular endothelial growth factor [12]. The main goal of this article is to present a various biological activity of 2-aminobenzimidazole derivatives. During the past 20 years the biological activity of 2-aminobenzimidazole have been studied. Based on a review of the chemical literature, derivatives of 2-aminobenzimidazole showed a multipharmacological effects such as hypotensive effect [28], antiinflammatory effect [20] or antibacterial activity. Some chemical compounds, which contain in their structure 2-aminobenzimidazole system inhibit neurodegeneration and in the future they may be used in a treatment of Alzheimer’s disease or Parkinson’s disease [32]. Some of described derivatives of 2-aminobenimidazole can be used in a treatment of metabolic syndrome and diabetes [38]. Synthesis of new 2-aminobenzimidazole derivatives with anticancer activity is now one of the most important direction of research conducted on this group of compounds. Present compounds exhibit anticancer, antiproliferate, neuroprotetic and antiinflaminatory activity. Some of them can be used in a treatment of diabetes and hypertension.
    Źródło:
    Wiadomości Chemiczne; 2012, 66, 9-10; 840-865
    0043-5104
    2300-0295
    Pojawia się w:
    Wiadomości Chemiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Aktywność biologiczna pochodnych 2-amino -1H-benzimidazolu. Część I
    Biological activity of 2-amino -1H-benzimidazole derivatives. Part I
    Autorzy:
    Nawrocka, W. P.
    Nowicka, A.
    Liszkiewicz, H.
    Powiązania:
    https://bibliotekanauki.pl/articles/171654.pdf
    Data publikacji:
    2012
    Wydawca:
    Polskie Towarzystwo Chemiczne
    Tematy:
    pochodne 2-aminobenzimidazolu
    aktywność biologiczna
    2-aminobenzimidazole derivatives
    biological activity
    Opis:
    The main goal of this article is to present a various biological activity of 2-aminobenzimidazole derivatives. During the past 20 years the biological activity of 2-aminobenzimidazole have been studied. 2-Aminobenzimidazole occurs in a broad spectrum of drugs and pharmacological agents with anticancer [21], antibacterial [14], antiviral [10], analgesic or antiaggregatory properties. There are 30 drugs, 2-aminobenzimidazole derivatives, registered in the world. Mebendazole represents a big group of antiparasitic drugs [25]. Antihistaminic II-nd generation drug with selective activity towards H1 receptors represents Astemizol [2]. Antiviral drugs are: Enviroksym and its isomer Zinviroksym and Enviraden [3–5]. Synthesized 2-aminobenzimidazole derivatives are active against HCV [7], HIV [8, 9] or HCHV [11]. Selected compounds exhibit antiviral [3–5], antifungal [22–24] and antiparasitic [26–28] activity. Some of them can be used in the treatment of bacterial infections [12–14]. Many of 2-aminobenzimidazole analogues are histamine H1, H2, H3 and also H4 receptor antagonists [30, 33, 35, 39].
    Źródło:
    Wiadomości Chemiczne; 2012, 66, 9-10; 811-838
    0043-5104
    2300-0295
    Pojawia się w:
    Wiadomości Chemiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Syntezy, struktury i aktywność biologiczna pochodnych imidazo[4,5-b] pirydyny. Część 1
    Synthesis, structures and biological activity of imidazo [4,5-b]pyridine derivatives. Part 1
    Autorzy:
    Liszkiewicz, H.
    Nowicka, A.
    Nawrocka, W. P.
    Powiązania:
    https://bibliotekanauki.pl/articles/171672.pdf
    Data publikacji:
    2012
    Wydawca:
    Polskie Towarzystwo Chemiczne
    Tematy:
    pochodne imidazo[4,5-b]pirydyny
    aktywność biologiczna
    synteza
    struktura
    imidazo[4,5-b]pyridine derivatives
    biological activity
    synthesis
    structure
    Opis:
    This review presents most of the literature data about imidazo[4,5-b]pyridine derivatives and their biological activity. The main goal of this paper is to present various methods for the preparation of imidazo[4,5-b]pyridine analogues. There are some drugs, imidazo[4,5-b]pyridine derivatives, registered in the world, which exhibit diverse pharmacological activities. Noberastine [4] represent antihistaminic II generation drug with selective activity to H1 receptors. Tenatoprazole [5] is a novel proton pump inhibitor with a prolonged plasma half-life which possesses antiulcer activity. Sulmazole [3] is a new cardiotonic agent, an A1 adenosine receptor antagonist. Based on the review of the chemical literature, derivatives of imidazole[4,5-b] pyridine showed a multipharmacological effects. Presented compounds exhibit anticancer [14, 17, 19], antidepressant [44, 45], cardiotonic, anticoagulant [37] activities. Some of them can be used in the treatment of heart diseases [3]. There were also described derivatives of imidazo[4,5-b]pyridine with the potential use in the treatment of diabetes [48], hypertension and hyperlipidemia. Some chemical compounds which contain in their structure the imidazo[4,5-b]pyridine system inhibit neurodegeneration [34, 38] and can be used in the treatment of neurodegenerative disorders eg. Parkinson’s disease, Alzheimer’s disease or multiple sclerosis. In addition, some of the imidazo[4,5-b]pyridine possess antivirial [40–42], antimicrobial and cytotoxic activities.
    Źródło:
    Wiadomości Chemiczne; 2012, 66, 11-12; 1071-1095
    0043-5104
    2300-0295
    Pojawia się w:
    Wiadomości Chemiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Syntezy, struktury i aktywność biologiczna pochodnych imidazo[4,5-b] pirydyny. Część II
    Synthesis, structures and biological activity of imidazo[4,5-b]pyridine derivatives. Part 2
    Autorzy:
    Liszkiewicz, H.
    Nowicka, A.
    Nawrocka, W. P.
    Powiązania:
    https://bibliotekanauki.pl/articles/171764.pdf
    Data publikacji:
    2013
    Wydawca:
    Polskie Towarzystwo Chemiczne
    Tematy:
    pochodne imidazo[4,5-b]pirydyny
    aktywność biologiczna
    syntezy
    struktury
    imidazo[4,5-b]pyridine derivatives
    biological activity
    synthesis
    structures
    Opis:
    The main goal of this article is to present selected syntheses, structures and a various biological activity of imidazo[4,5-b]pyridine derivatives. During the past 20 years the biological activity of imidazo[4,5-b]pyridine have been intensively studied. Based on the review of the chemical literature, it was shown that derivatives of imidazole[4,5-b]pyridine showed a multipharmacological effects such as antibacterial effect [20–22] and antituberculotic activity [25–33], nonsteroidal antiinflammatory activity [35–43] and analgesic [44, 45] effect. Among compounds of this class antagonists of angiotensin II receptors that exhibit hypotensive activity are also known [9–11]. Compounds containing imidazo[4,5-b]pyridine moiety can be synthesized from different substrates. The most useful starting compounds for the synthesis of imidazo[4,5-b]pyridine are derivatives of 2,3-diaminopyridine [1–3].
    Źródło:
    Wiadomości Chemiczne; 2013, 67, 3-4; 227-250
    0043-5104
    2300-0295
    Pojawia się w:
    Wiadomości Chemiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Zasady Schiffa : wybrane syntezy, reakcje i aktywność biologiczna
    Schiff bases : selected syntheses, reactions and biological activity
    Autorzy:
    Nowicka, A.
    Liszkiewicz, H.
    Nawrocka, W. P.
    Powiązania:
    https://bibliotekanauki.pl/articles/172082.pdf
    Data publikacji:
    2014
    Wydawca:
    Polskie Towarzystwo Chemiczne
    Tematy:
    zasada Schiffa
    iminy
    aktywność biologiczna
    synteza
    struktura
    Schiff bases
    imines
    biological activity
    synthesis
    structure
    Opis:
    Schiff bases are compounds with a functional group that contains a carbon- -nitrogen double bond with the nitrogen atom connected to an aryl or alkyl group. Schiff bases are condensation products of primary amines with carbonyl compound. Several studies showed that the presence of a lone pair of electrons on the nitrogen atom of the azomethine determine biological and chemical properties of imines. Schiff bases are generally excellent chelating agents, because of the special properties of C=N bond. Their metal complexes have been widely studied because they possess anticancer in vitro and herbicidal applications. Imines also have biological importance. Schiff bases are common enzymatic intermediates where an amine reacts with an aldehyde or ketone of a cofactor or a substrate. Imines have been reported for their biological properties such as antibacterial (E. coli, S. aureus), antifungal (C. albicans) activities. A large number of different Schiff bases are active against a wide range of protozoan (T. gypseum, P. viticola).
    Źródło:
    Wiadomości Chemiczne; 2014, 68, 3-4; 187-209
    0043-5104
    2300-0295
    Pojawia się w:
    Wiadomości Chemiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Syntezy wybranych zasad Mannicha o aktywności przeciwbakteryjnej i przeciwgrzybiczej in vitro
    Synthesis and antibacterial and antifungal activity in vitro of selected Mannich bases
    Autorzy:
    Nowicka, A.
    Liszkiewicz, H.
    Nawrocka, W. P.
    Powiązania:
    https://bibliotekanauki.pl/articles/172209.pdf
    Data publikacji:
    2014
    Wydawca:
    Polskie Towarzystwo Chemiczne
    Tematy:
    zasada Mannicha
    aktywność przeciwbakteryjna
    aktywność przeciwgrzybicza
    Mannich bases
    antibacterial activity
    antifungal activity
    Opis:
    The Mannich reaction is a three-component condensation reaction involving an active hydrogen containing compound, formaldehyde and a primary or a secondary amine. The Mannich reaction is one of the most important basic reaction types in organic chemistry. This kind of aminoalkylation is important for the synthesis and modification of biologically active compounds. Many studies have shown that Mannich bases possesses potent biological activities: antibacterial, antifungal, anti-inflammatory and antimalarial properties. Mannich bases – substituted products containing different heterocyclic moiety in their structures seem to be suitable candidates for further chemical modifications and might be of interest as pharmacologically active compounds. The main goal of this article is to present synthesis and antimicrobial activity of selected Mannich bases. The Mannich reaction is known to be very useful for the synthesis of antibacterial compounds. The Mannich bases, containing various heterocyclic systems were identified as potent antimicrobial agents. Obtained in Mannich reaction derivatives of antibacterial drugs: ciprofloxacine, norfloxacine demonstrate higher antibacterial activity than used drugs, while derivatives of drugs: ibuporofen or phenytoine changed the profile of action of new synthesized compounds.
    Źródło:
    Wiadomości Chemiczne; 2014, 68, 3-4; 161-186
    0043-5104
    2300-0295
    Pojawia się w:
    Wiadomości Chemiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-11 z 11

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