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Wyświetlanie 1-2 z 2
Tytuł:
Efekty synergiczne i antagonistyczne między biosurfakantami z grupy soforolipidów i alkilopoliglikozydów o zróżnicowanej długości łańcucha alkilowego oraz ich wykorzystanie w projektowaniu środków myjących dla przemysłu spożywczego
Synergistic and antagonistic effects between biosurfactants from the group of soforolipids and alkylopolyglikosides of various alkyl chain lenghts and their use in the design of cleaning agents for the food industry
Autorzy:
Jędrzejczyk, Anna
Pełech, Robert
Janus, Ewa
Powiązania:
https://bibliotekanauki.pl/articles/2200420.pdf
Data publikacji:
2023
Wydawca:
Polskie Towarzystwo Chemiczne
Tematy:
biosurfaktanty
soforolipidy
alkilopoliglikozydy
działanie synergistyczne
działanie antagonistyczne
biosurfactants
sophorolipids
alkyl polyglycosides
synergistic effects
antagonistic effects
Opis:
The paper presents the results of testing the performance parameters of mixtures of biosurfactants from the group of sophorolipids and alkylpolyglycosides with different alkyl chain lengths. In order to determine the synergistic and antagonistic effects in two-component surfactant systems, research was carried out to determine the performance parameters determining their use in washing preparations, such as foam height (FH) and foam stability (FS) and wetting angle analysis (CA). The results are presented in tables 3, 4 and 5. Determination of the content of the active substance in the raw material samples was carried out using the method of refractometric determination of the refractive index. Both synergistic and antagonistic effects were found. On the basis of the obtained test results, the highest synergistic effect of performance parameters was obtained for the mixture of biosurfactants from the group of sophorolipids and the alkylpolyglycoside D-glucopyranose, oligomer, C10-16-alkylglycosides. In this case, the synergy occurred for all performance parameters FH (14%), FS (28%) and CA (46%). The synergistic effects were used to design a concentrated formulation of a cleaning agent in the food industry. The planned experiment method was used in order to obtain an optimal solution in terms of ensuring the appropriate level of cleaning efficiency. A twenty-two-point experiment plan was developed based on the Scheff model in order to optimize the composition in terms of obtaining the operational parameters of the mixture constituting the formulation's framework assumed in the optimization criteria. Optimization criteria were determined on the basis of studies of commercially available analogues. Thanks to the use of formulations of raw materials exhibiting synergistic effects in the design of the frame, the foam height and stability higher than those specified in the optimization criteria were obtained.
Źródło:
Wiadomości Chemiczne; 2023, 77, 3-4; 179--200
0043-5104
2300-0295
Pojawia się w:
Wiadomości Chemiczne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Synergistyczne działanie flukonazolu i laktonów ftalidowych jako czynnik ograniczający stosowanie leków azolowych w leczeniu kandidoz
Synergistic effect of fluconazole and phtalide lactones as a factor limiting the use of azole drugs against candidiasis
Autorzy:
Olejniczak, Teresa
Powiązania:
https://bibliotekanauki.pl/articles/27310047.pdf
Data publikacji:
2023
Wydawca:
Polskie Towarzystwo Chemiczne
Tematy:
efekt synergii
Candida albicans
laktony ftalidowe
flukonazol
synergistic effect
phthalide lactones
fluconazole
Opis:
The resistance of Candida albicans and other pathogenic yeasts to azole antifungal drugs has increased rapidly in recent years and is a significant problem in clinical therapy. The current state of pharmacological knowledge precludes the withdrawal of azole drugs, as no other active substances have yet been developed that could effectively replace them. Therefore, one of the anti-yeast strategies may be therapies that can rely on the synergistic action of natural compounds and azoles, limiting the use of azole drugs against candidiasis. Synergy assays perperformed in vitro were used to assess drug interactions Fractional Inhibitory Concentration Index. The synergistic effect of fluconazole (1) and three synthetic lactones identical to those naturally occurring in celery plants—3-n-butylphthalide (2), 3-n-butylidenephthalide (3), 3-n-butyl-4,5,6,7-tetrahydrophthalide (4)—against Candida albicans ATCC 10231, C. albicans ATCC 2091, and C. guilliermondii KKP 3390 was compared with the performance of the individual compounds separately. MIC90 (the amount of fungistatic substance (in µg/mL) inhibiting yeast growth by 90%) was determined as 5.96–6.25 µg/mL for fluconazole (1) and 92–150 µg/mL for lactones 2–4. With the simultaneous administration of fluconazole (1) and one of the lactones 2–4, it was found that they act synergistically, and to achieve the same effect it is sufficient to use 0.58–6.73 µg/mL fluconazole (1) and 1.26–20.18 µg/mL of lactones 2–4. Based on biological research, the influence of the structure on the fungistatic activity and the synergistic effect were determined.
Źródło:
Wiadomości Chemiczne; 2023, 77, 5-6; 555-567
0043-5104
2300-0295
Pojawia się w:
Wiadomości Chemiczne
Dostawca treści:
Biblioteka Nauki
Artykuł
    Wyświetlanie 1-2 z 2

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