- Tytuł:
- Mechanical unfolding of DDFLN4 studied by coarse-grained knowledge-based CABS model
- Autorzy:
-
Kouza, M.
Jamroz, M.
Gront, D.
Kmiecik, S.
Koliński, A. - Powiązania:
- https://bibliotekanauki.pl/articles/1935814.pdf
- Data publikacji:
- 2014
- Wydawca:
- Politechnika Gdańska
- Tematy:
-
CABS
coarse-grained modeling
lattice model
mechanical unfolding of proteins - Opis:
- Mechanical unfolding of the fourth domain of Distyostelium discoideum filamin ( DDFLN 4) was studied using a CABS – coarse-grained knowledge-based protein model. Our study demonstrates that CABS is capable of reproducing the unfolding free energy landscape of protein unfolding and highlights an important role of non-native interactions in the protein unfolding process. The obtained three peaks in the force-extension profile suggest a four-state picture of DDFLN 4 protein unfolding and correspond reasonably to the results of the all-atom simulation in explicit solvent.
- Źródło:
-
TASK Quarterly. Scientific Bulletin of Academic Computer Centre in Gdansk; 2014, 18, 4; 373--378
1428-6394 - Pojawia się w:
- TASK Quarterly. Scientific Bulletin of Academic Computer Centre in Gdansk
- Dostawca treści:
- Biblioteka Nauki
Artykuł