- Tytuł:
- Pathogenesis of middle ear acquired cholesteatoma in the light of the research using high throughput, “omics”, technologies of molecular biology
- Autorzy:
-
Makuszewska, Maria
Bartoszewicz, Robert
Niemczyk, Kazimierz - Powiązania:
- https://bibliotekanauki.pl/articles/1399639.pdf
- Data publikacji:
- 2019
- Wydawca:
- Index Copernicus International
- Tematy:
-
aquired cholesteatoma
gene expression
microarray
molecular biology
pathogenesis
proteomic analysis - Opis:
- Cholesteatoma is described as cystic lesion consisting of keratinizing squamous cell epithelium, filed with keratin debris, surrounded by inflammatory fibrous tissue, gradually expanding in the middle ear and causing destruction of neighboring bones. This paper presents brief review of existing hypotheses explaining its etiology in the light of the researches using high throughput, “omics”, technologies of molecular biology. Classic theories of pathogenesis of acquired cholesteatoma as: immigration, squamous metaplasia, basal cell hyperplasia or invagination theory have not been able to explain fully all pathological processes observed in cholesteatoma tissue. This also concerns the newer concepts that cholesteatoma is a result of mucosal traction generated by interaction of migrating opposing surfaces, a natural attempt by the body to cure the underlying inflammation in the cavity or chronic wound healing process triggered by micro defects in the basement membrane of the epithelium in the retraction pocket. Introduction of high-throughput, “omics”, technologies of molecular biology to the studies under cholesteatoma pathogenesis allowed identification of cholesteatoma-related gene expression signatures using full-genome microarrays as well as proteomic analysis of cholesteatoma. Those studies confirmed known pathological processes observed in cholesteatoma tissue such as: high proliferative activity, decreased signal transduction, active immunological response, alterations in the extracellular matrix, increased expression of proinflammatory cytokines, neovascularization and may others. This technique allows precise and complete insight into molecular mechanisms in those processes. However, it is still unknown what is the cause that trigger epithelial hyperplasia, inhibited migration and inflammatory response in the preexisting retraction pocket.
- Źródło:
-
Polski Przegląd Otorynolaryngologiczny; 2019, 8, 3; 14-19
2084-5308
2300-7338 - Pojawia się w:
- Polski Przegląd Otorynolaryngologiczny
- Dostawca treści:
- Biblioteka Nauki
Artykuł