- Tytuł:
- Characteristics of selected second-generation antiepileptic drugs used in dogs
- Autorzy:
-
Ziolkowski, H.
Jaroszewski, J.J.
Ziolkowska, N.
Jasiecka, A. - Powiązania:
- https://bibliotekanauki.pl/articles/30162.pdf
- Data publikacji:
- 2012
- Wydawca:
- Polska Akademia Nauk. Czytelnia Czasopism PAN
- Tematy:
-
second generation drug
antiepileptic drug
dog
veterinary medicine
pharmacokinetics - Opis:
- A significant number of cases of clinical canine epilepsy remain difficult to control in spite of the applied treatment. At the same time, the range of antiepileptic drugs is increasingly wide, which allows efficient treatment. In the present paper we describe the pharmacodynamics and pharmacokinetics of the newer antiepileptic drugs which were licensed after 1990 but are still not widely used in veterinary medicine. The pharmacokinetic profiles of six of these drugs were tested on dogs. The results of experimental studies suggest that second generation antiepileptic drugs may be applied in mono- as well as in poli- treatment of canine epilepsy because of the larger safety margin and more advantageous pharmacokinetic parameters. Knowledge of the drugs’ pharmacokinetics allows its proper clinical appliance, which, in turn, gives the chance to improve the efficiency of pharmacotherapy of canine epilepsy.
- Źródło:
-
Polish Journal of Veterinary Sciences; 2012, 15, 3
1505-1773 - Pojawia się w:
- Polish Journal of Veterinary Sciences
- Dostawca treści:
- Biblioteka Nauki
Artykuł