Autor: Kowalski, C J - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: Diurnal and seasonal changes in endogenous melatonin levels in the blood plasma in dogs
Autorzy:: Zan, R S
Rolinski, Z
Kowalski, C J
Bojarska-Junak, A
Madany, J
Powiązania:: https://bibliotekanauki.pl/articles/30357.pdf
Data publikacji:: 2013
Wydawca:: Polska Akademia Nauk. Czytelnia Czasopism PAN
Opis:: This paper describes research on the levels of endogenous melatonin (MLT) in the blood serum in dogs in different seasons (March, June, September, December) and at different times of day (11:00, 12:00, 23:00, 24:00 and 1:00), using immunoassay method. Blood samples were collected in the diurnal cycle, in consecutive seasons. The conducted studies show that MLT levels undergo clear changes in both the diurnal cycle, as well as in seasonal one in this species.
Źródło:: Polish Journal of Veterinary Sciences; 2013, 16, 4
1505-1773
Pojawia się w:: Polish Journal of Veterinary Sciences
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 2.

Tytuł:: Pharmacokinetics of tramadol and metabolites after injective administrations in dogs
Autorzy:: Giorgi, M.
Del Carlo, S.
Lebkowska-Wieruszewska, B.
Kowalski, C.J.
Saccomanni, G.
Powiązania:: https://bibliotekanauki.pl/articles/30304.pdf
Data publikacji:: 2010
Wydawca:: Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:: pharmacokinetics
tramadol
metabolite
dog
bioavailability
intravenous injection
intramuscular injection
plasma
tramadol concentration
Opis:: The aim of this study was to determine the pharmacokinetics of tramadol and its main metabolites after IV and IM injections. The pharmacokinetic cross-over study was carried out on 6 healthy male beagle dogs. Tramadol was administered by intravenous (IV) and intramuscular (IM) injection at 4 mg/kg. Tramadol and its main metabolites O-desmethyl-tramadol (M1), N-,N-didesmethyl-tramadol (M2) and N-,O-didesmethyl-tramadol (M5) concentrations were measured in plasma samples by a HPLC coupled with fluorimetric detection; pharmacokinetic evaluations were carried out with a compartmental and non-compartmental model for tramadol and its metabolites, respectively. The bioavailability of the drug, ranging between 84-102% (mean 92%), was within the generally accepted values for a positive bioequivalence decision of (80-125%). After the IM injection the mean plasma drug concentration peak was reached after a Tmax of 0.34 h with a Cmax of 2.52 μg/mL. No therapeutic relevant differences were observed between IM and IV administration. The minimal effective plasma concentration was reached after a few minutes and maintained for about 6-7 h in both administrations. M1 plasma concentration was low and the amounts of the other metabolites produced were analogous in both routes of administration. In conclusion, tramadol was rapidly and almost completely absorbed after IM administration and its systemic availability was equivalent to the IV injection. The different onset time and duration of action observed were very small and probably therapeutically irrelevant. The IM injection is a useful alternative to IV injection in the dog.
Źródło:: Polish Journal of Veterinary Sciences; 2010, 13, 4
1505-1773
Pojawia się w:: Polish Journal of Veterinary Sciences
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 3.

Tytuł:: Pharmacokinetic profiles of 5 mg/kg ibudilast, a phosphodiesterase inhibitor, orally administered to dogs in fasted and non-fasted states. A preliminary study.
Autorzy:: Łebkowska-Wieruszewska, B.
De Vito, V.
Kowalski, C.J.
Owen, H.
Poapolathep, A.
Lisowski, A.
Giorgi, M.
Powiązania:: https://bibliotekanauki.pl/articles/2087742.pdf
Data publikacji:: 2018
Wydawca:: Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:: pharmacokinetics
ibudilast
dog
non-selective cyclic nucleotide phosphodiesterase inhibitor
Źródło:: Polish Journal of Veterinary Sciences; 2018, 21, 2; 281-285
1505-1773
Pojawia się w:: Polish Journal of Veterinary Sciences
Dostawca treści:: Biblioteka Nauki

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