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Wyświetlanie 1-7 z 7
Tytuł:
Incidence, morbidity and 5-year survival of colorectal cancer patients in the Kujawsko-Pomorskie voivodship in 2005-2011, based on data from the National Health Fund
Autorzy:
Nowicki, Andrzej
Dahms, Sylwia
Powiązania:
https://bibliotekanauki.pl/articles/1392418.pdf
Data publikacji:
2018
Wydawca:
Index Copernicus International
Tematy:
colorectal cancer
incidence
morbidity
5-year survival
Opis:
Introduction: Incidence, morbidity and 5-year survival rates illustrate the epidemiological situation of colorectal cancer and assess effectiveness of the treatment. In Poland, the National Health Fund is the payer of services. The data related to morbidity, incidence, and 5-year survival may be supplementary to the epidemiological data of the National Cancer Registry. Objective: Analysis of services granted by NHF in Bydgoszcz to persons with diagnosed colorectal cancer in 2006–2011 including the assessment of incidence, morbidity and 5-year survival of the population in the Kujawsko-Pomorskie province. Material and methods: The study analyzed the services recorded in the database of the National Health Fund in Bydgoszcz in 2006-2011 given to patients with colorectal cancer. The Kaplan-Meier method and the gambling rate were used to determine the probability of survival. Results: In 2006–2011, men were offered 10.1% more services than women. The most frequent services regarded colorectal cancer (48.9%), rectal cancer (43.8%) and esophageal cancer (7.2%). In total, 50410 services were provided. Despite increase in the number of women in the population, 388 more men died than women. The probability of survival was 46.8 % and 42.6% for men and women, respectively, furthermore 41.8%, 44.2% and 48.9% for colon cancer and esophageal and rectal folds cancer, respectively. Conclusions: In the Kujawsko-Pomorskie province during the period of 2006–2011, the number of diagnosed colorectal cancers increased as did the overall number of services provided. There was also a downward trend for the total number of services granted in relation to the increase in the number of new diagnosed cases. Incidence and morbidity rates were variable, gradually increasing in subsequent years and amounted to 59/100000 and 67/100000, 355/100000 and 408/100000 in 2010 and 2011, respectively. The probability of 5-year survival was 45.2%. Diagnosis of a disease in patients above 69 years of age increased the likelihood of death.
Źródło:
Polish Journal of Surgery; 2018, 90, 4; 1-8
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Prediction of Survival in Patients with Unresectable Colorectal Liver Metastases
Autorzy:
Hołówko, Wacław
Grąt, Michał
Hinderer, Barbara
Orlińska, Izabela
Krawczyk, Marek
Powiązania:
https://bibliotekanauki.pl/articles/1395796.pdf
Data publikacji:
2014-07-01
Wydawca:
Index Copernicus International
Tematy:
colorectal cancer
liver metastases
unresectable metastases
survival prediction
Opis:
Liver metastases are diagnosed synchronously with the primary tumour in 25% of patients with colorectal cancer. A half of the remaining patients develop liver metastases within 3 years following colectomy. At present, the only radical treatment of metastases is liver resection. Only 2.6% of patients survive 3 years if such treatment is not implemented. The aim of the study was to assess predictive factors of long-term survival in the group of patients with unresectable colorectal liver metastases carcinoma. Material and methods. Of 1029 patients with colorectal liver metastases, who were treated in the Department of General, Transplant and Liver Surgery of the Medical University of Warsaw in the years 2006-2012, cases of liver metastases assessed intraoperatively as unresectable were selected. The retrospective analysis included 85 patients. Based on the medical documentation, information concerning age, sex, characteristics of primary and secondary tumours, reasons for unresectability, neoadjuvant chemotherapy as well as local treatment of liver tumours was collected. Preoperative serum concentrations of CEA and CA 19-9 markers were considered. The Cox regression model, Kaplan- Meier estimator and log-rank test were applied in the statistical analyses. Results. The most common reason for unresectability were: number of metastases in 31 patients (36.5%) and extrahepatic metastases in 19 cases (22.4%). Overall survival in the entire group was 56.1% and 15.5% after 1 and 3 years respectively. A single-factor analysis showed that CEA serum levels (p=0.032; HR=1.002 per increase by 1 ng/ml) and the presence of extrahepatic metastases (p=0.037; HR=2.06) were predictors of worse survival. In a multivariate analysis, CEA concentration (p=0.017; HR=1.002 per increase by 1 ng/ml) was an independent predictor of death whereas the presence of extrahepatic metastases were not statistically significant (p=0.059; HR=2.09). Conclusions. Serum concentration of CEA marker is an independent predictor of worse survival, but the presence of extrahepatic metastases shows a similar tendency
Źródło:
Polish Journal of Surgery; 2014, 86, 7; 319-324
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Vascular Endothelial Growth Factor and Survivin Immunostaining in Gastric Adenocarcinoma
Autorzy:
Bury, Jarosław
Szumiło, Justyna
Dąbrowski, Andrzej
Ciechański, Aleksander
Śliwińska, Justyna
Wallner, Grzegorz
Powiązania:
https://bibliotekanauki.pl/articles/1396680.pdf
Data publikacji:
2012-07-01
Wydawca:
Index Copernicus International
Tematy:
vascular endothelial growth factor
VEGF
survivin
adenocarcinoma
stomach
survival
Opis:
Two molecules - vascular endothelial growth factor involved in new vessels formation and survivin - antiapoptotic protein, reported to be associated with worse prognosis in various malignancies have been chosen for the study. Both are potential target for novel therapiesThe aim of the study was to determine the immunostaining of VEGF and survivin in gastric carcinoma and to analyse their relationship to the selected clinicopathological features and survival.Material and methods. Formalin-fixed, paraffin-embedded sections from 41 gastric adenocarcinomas were used for immunohistochemical reaction with monoclonal antibodies against vascular endothelial growth factor and survivin. The results were compared with selected clinicopathological features and survival.Results. Positive immunohistochemical reaction for vascular endothelial growth factor and survivin was revealed in 24 (58,53%) and 30 (73,17%), gastric carcinomas respectively. Vascular endothelial growth factor-negative gastric carcinomas were significantly more common in cases without metastases to regional lymph nodes and distant organs and in less advanced cases. Similar, distant metastases were also statistically less common in survivin-negative carcinomas. The differences in immunohistochemical reactions for survivin between less and more advanced cases almost reach statistical significance. The only factors significantly influenced 1, 2 and 3-year survival were vascular endothelial growth factor and survivin status. Statistically significant higher percentage of survival was noted in patients with vascular endothelial growth factor- and survivin-negative tumors.Conclusions. It seems that vascular endothelial growth factor and survivin play role in local invasion and spread of gastric adenocarcinoma and negatively influences survival. However, further studies are required to assess their true usefulness in the clinical practice.
Źródło:
Polish Journal of Surgery; 2012, 84, 7; 341-347
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Evolution Of The Results Of 1500 Liver Transplantations Performed In The Department Of General, Transplant And Liver Surgery Medical University Of Warsaw
Autorzy:
Krawczyk, Marek
Grąt, Michał
Grąt, Karolina
Wronka, Karolina
Krasnodębski, Maciej
Stypułkowski, Jan
Masior, Łukasz
Hołówko, Wacław
Ligocka, Joanna
Nyckowski, Paweł
Wróblewski, Tadeusz
Paluszkiewicz, Rafał
Patkowski, Waldemar
Zieniewicz, Krzysztof
Pączek, Leszek
Milkiewicz, Piotr
Ołdakowska-Jedynak, Urszula
Najnigier, Bogusław
Dudek, Krzysztof
Remiszewski, Piotr
Grzelak, Ireneusz
Kornasiewicz, Oskar
Kotulski, Marcin
Smoter, Piotr
Grodzicki, Mariusz
Korba, Michał
Kalinowski, Piotr
Skalski, Michał
Zając, Krzysztof
Stankiewicz, Rafał
Przybysz, Marta
Cieślak, Bartosz
Nazarewski, Łukasz
Nowosad, Małgorzata
Kobryń, Konrad
Wasilewicz, Michał
Raszeja-Wyszomirska, Joanna
Piwowarska, Jolanta
Giercuszkiewicz, Dorota
Sańko-Resmer, Joanna
Rejowski, Sławomir
Szydłowska-Jakimiuk, Monika
Górnicka, Barbara
Wróblewska-Ziarkiewicz, Bogna
Mazurkiewicz, Michał
Niewiński, Grzegorz
Pawlak, Jacek
Pacho, Ryszard
Powiązania:
https://bibliotekanauki.pl/articles/1395614.pdf
Data publikacji:
2015-05-01
Wydawca:
Index Copernicus International
Tematy:
liver transplantation
survival
outcomes
donors
center experience
center volume
Opis:
Liver transplantation is a well-established treatment of patients with end-stage liver disease and selected liver tumors. Remarkable progress has been made over the last years concerning nearly all of its aspects. The aim of this study was to evaluate the evolution of long-term outcomes after liver transplantations performed in the Department of General, Transplant and Liver Surgery (Medical University of Warsaw). Material and methods. Data of 1500 liver transplantations performed between 1989 and 2014 were retrospectively analyzed. Transplantations were divided into 3 groups: group 1 including first 500 operations, group 2 including subsequent 500, and group 3 comprising the most recent 500. Five year overall and graft survival were set as outcome measures. Results. Increased number of transplantations performed at the site was associated with increased age of the recipients (p<0.001) and donors (p<0.001), increased rate of male recipients (p<0.001), and increased rate of piggyback operations (p<0.001), and decreased MELD (p<0.001), as well as decreased blood (p=0.006) and plasma (p<0.001) transfusions. Overall survival was 71.6% at 5 years in group 1, 74.5% at 5 years in group 2, and 85% at 2.9 years in group 3 (p=0.008). Improvement of overall survival was particularly observed for primary transplantations (p=0.004). Increased graft survival rates did not reach the level of significance (p=0.136). Conclusions. Long-term outcomes after liver transplantations performed in the Department of General, Transplant and Liver Surgery are comparable to those achieved in the largest transplant centers worldwide and are continuously improving despite increasing recipient age and wider utilization of organs procured from older donors.
Źródło:
Polish Journal of Surgery; 2015, 87, 5; 221-230
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
In Vitro Chemo-Sensitivity Assay Guided Chemotherapy is Associated with Prolonged Overall Survival in Cancer Patients
Autorzy:
Udelnow, Andrej
Schönfelder, Manfred
Würl, Peter
Halloul, Zuhir
Meyer, Frank
Lippert, Hans
Mroczkowski, Paweł
Powiązania:
https://bibliotekanauki.pl/articles/1396300.pdf
Data publikacji:
2013-06-01
Wydawca:
Index Copernicus International
Tematy:
chemo-sensivity in vitro
survival prediction
chemotherapy
drug sensivity
cancer
Opis:
The overall survival (OS) of patients suffering From various tumour entities was correlated with the results of in vitro-chemosensitivity assay (CSA) of the in vivo applied drugs. Material and methods. Tumour specimen (n=611) were dissected in 514 patients and incubated for primary tumour cell culture. The histocytological regression assay was performed 5 days after adding chemotherapeutic substances to the cell cultures. n=329 patients undergoing chemotherapy were included in the in vitro/in vivo associations. OS was assessed and in vitro response groups compared using survival analysis. Furthermore Cox-regression analysis was performed on OS including CSA, age, TNM classification and treatment course. Results. The growth rate of the primary was 73-96% depending on tumour entity. The in-vitro response rate varied with histology and drugs (e.g. 8-18% for methotrexate and 33-83% for epirubicine). OS was significantly prolonged for patients treated with in vitro effective drugs compared to empiric therapy (log-rank-test, p=0.0435). Cox-regression revealed that application of in vitro effective drugs, residual tumour and postoperative radiotherapy determined the death risk independently. Conclusions. When patients were treated with drugs effective in our CSA, OS was significantly prolonged compared to empiric therapy. CSA guided chemotherapy should be compared to empiric treatment by a prospective randomized trial.
Źródło:
Polish Journal of Surgery; 2013, 85, 6; 340-347
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Analysis of disease free survival in cutaneous melanoma patients subject to sentinel lymph node biopsy
Autorzy:
Łobaziewicz, Wojciech
Szloch, Joanna
Wajda, Justyna
Legkiy, Oleksandr
Marczyk, Elżbieta
Wysocki, Wojciech
Powiązania:
https://bibliotekanauki.pl/articles/1391682.pdf
Data publikacji:
2020
Wydawca:
Index Copernicus International
Tematy:
cutaneous melanoma
disease free survival
lymphadenectomy
sentinel lymph node biopsy
SNB
Opis:
Introduction: Cutaneous melanoma is estimated for 2% of malignant neoplasms occurring in humans. It is characterized by a high level of malignancy and low sensitivity to cytostatic drugs. The incidence of cutaneous melanoma is increasing in Poland. The lymphatic system is the most common route of dissemination of this neoplasm. The appearance of a sentinel node biopsy technique has made it possible to identify patients with a regionally advanced disease. It is a minimally invasive method with a small percentage of complications. Aim: Analysis of disease free survival (DFS) in cutaneous melanoma patients with sentinel lymph node biopsy. Material and methods: The analysis included 222 patients with cutaneous melanoma treated in the Department of Oncological Surgery in 2010–2015, who underwent a sentinel node biopsy. The study group consisted of 136 women and 86 men, the average age of patients was 59 years. Patients were qualified for sentinel node biopsy based on clinical evaluation and ultrasound of regional lymph nodes. The average follow-up was 25.1 months. About 2 hours before surgery, patients received a radioisotope, then lymphoscintigraphy SPECT was performed. Additionally, they were administered the Patent Blue dye in the operating room. Results: The sentinel node was identified in 217 patients (98%), and the average sentinel nodes were 2.25. Twenty-seven patients (12%) had a metastasis in sentinel nodes. In this group, the duration of symptom free survival was significantly shorter. Sentinel node status and age of the patient were independent factors affecting the prognosis of disease free survival. Conclusions: Sentinel node biopsy is a precise method to identify patients with cutaneous melanoma who have metastasis to regional lymph nodes, as well as the most important prognostic factor.
Źródło:
Polish Journal of Surgery; 2020, 92, 3; 15-21
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Does the Choice of Hospital Increase a Chance of Survival in Rectal Cancer?
Autorzy:
Pawlak, Mariusz
Morawiec, Zbigniew
Dziki, Łukasz
Morawiec, Jan
Kolacińska, Agnieszka
Dziki, Adam
Powiązania:
https://bibliotekanauki.pl/articles/1397012.pdf
Data publikacji:
2012-12-01
Wydawca:
Index Copernicus International
Tematy:
rectal cancer
prognostic factors
hospital caseload
5-year survival
local recurrence
Opis:
was to assess the impact of hospital caseload on long-term outcomes of rectal cancer patients. We posed two questions: 1. Does the number of operations carried out in the surgical department influence five year survival and local recurrence rates? 2. Does surgery alone without adjuvant therapy performed in the particular department affect long-term results? Material and methods. 215 consecutive rectal cancer patients treated in six hospitals of the Łódź district between 1994 and 1998 were enrolled into this prospective study. We analyzed patients in whom local excision, low anterior resection, abdominoperineal resection and Hartmann’s procedure were performed. 27 percent of patients received adjuvant therapy such as radio- or chemotherapy or both. Long-term results were compared between high and low volume institutions by means of local recurrence and five year survival rates. Results. In high volume departments; 69.2% of five year survival rates were obtained versus 46.6% for low volume institutions (p=0.00433). Similar differences were noted comparing local recurrence rates between the aforementioned groups: 19.7% versus 36.5%, respectively (p=0.00430). In surgically treated patients who did not receive adjuvant therapy statistically significant differences were found: 76.5% of patients operated on in high volume hospitals survived five years as compared with 42.9% for low caseload institutions (p=0.00013). Local recurrence rates were 15.5% for high caseload institutions and 38.5% for low caseload hospitals (p=0.00042). Conclusions. High volume hospitals achieved better results in rectal cancer patients with regard to five year survival and local recurrence rates. Better outcomes were also obtained in high caseload departments regarding surgically treated patients who did not receive adjuvant therapy.
Źródło:
Polish Journal of Surgery; 2012, 84, 12; 638-645
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
    Wyświetlanie 1-7 z 7

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