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    Wyświetlanie 1-6 z 6
    Tytuł:
    Higher Apoptosis Index and Proliferation Index in Colonocytes of Patients with Ulcerative Colitis in Remission
    Autorzy:
    Buczyński, Jarosław
    Spychalski, Michał
    Ławska-Wierzchniewska, Agnieszka
    Dziki, Adam
    Powiązania:
    https://bibliotekanauki.pl/articles/1396694.pdf
    Data publikacji:
    2012-06-01
    Wydawca:
    Index Copernicus International
    Tematy:
    apoptosis
    proliferation
    ulcerative colitis
    Opis:
    Ulcerative colitis (UC) is a inflammatory disease of large bowel. The amount of people suffering from UC increases from year to year. Pathogenesis of this affection is still not entirely clear. Mechanisms of proliferation and apoptosis in colonocytes in the course of the disease are defectedThe aim of the study was to assess the rate of proliferation and intensity of apoptosis in colonocytes in patients with diagnose UC.Material and methods. Colon pathological samples taken from patients with diagnosed ulceraive colitis were examined. Patients were in both clinical and endoscopic remission and were treated with mesalazin. They were patient of Department of General and Colorectal Surgery. To estimate proliferation index dye with monoclonal antibody against Ki67. To determine apoptosis level immunohistochemistry with antybody against Bax was used.Results. Average Ki-67 in the test group was 42,13%, the largest value amounted to 57% and the lowest of 33%. Average value of Bax was 1.47 and ranged between 0-3. High index of bax appear not only in the bottom of the crypt, but also at their outlet.Conclusions. In ulecerative colitis genetic and immunological disturbances occur despite treatment. Mesalazine acting only on certain routes associated with the UC holds the remission, without, however "the molecular remission". Thus, it appears that the results of our research are another proof of the necessary caution in weaning support treatment.
    Źródło:
    Polish Journal of Surgery; 2012, 84, 6; 271-275
    0032-373X
    2299-2847
    Pojawia się w:
    Polish Journal of Surgery
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The influence of socio-demographic and clinical factors on the process of acceptance of the disease among patients with ulcerative colitis
    Autorzy:
    Chrobak-Bień, Joanna
    Gawor, Anna
    Paplaczyk, Małgorzata
    Małecka-Panas, Ewa
    Gąsiorowska, Anita
    Powiązania:
    https://bibliotekanauki.pl/articles/1392911.pdf
    Data publikacji:
    2018
    Wydawca:
    Index Copernicus International
    Tematy:
    Acceptance of the disease
    ulcerative colitis
    Opis:
    Ulcerative colitis (UC) is a kind of inflammatory bowel disease involving rectal mucosa, or the rectum with colon, resulting in ulcerations in some cases. It is incurable and varies with periods of exacerbation and remission. The disease affects mainly population of highly-developed European or North American nations. It can relatively rarely be observed in South America, Asia and Africa. It is estimated that morbidity and incidence in those regions is about 10 times lower than in Europe and North America [1,2]. The incidence of UC in Europe is approximately 10 new cases per 100,000 people annually [3]. In Poland, epidemiology assessment is difficult due to a lack of reliable statistics. In Lower Silesia, 840 hospitalizations for UC on average are registered annually [4,5]. In UC pathogenesis, genetic, environmental and immunologic factors play an important role. UC can occur at any age, however, the peak incidence is observed between ages 20 and 40 and over 65 [6]. UC is incurable and accompanies the patient through the rest of his/her life. It varies with periods of exacerbation and remission, which impair everyday activities and lower patient’s quality of life. As a consequence, the patient generally feels bad, which is not only caused by gastrointestinal symptoms but also by emotional and psychological issues [7]. Nowadays, a clear tendency can be observed in medicine to include health and disease-related issues in biopsychosocial context, including social and psychological factors affecting the course of the disease. The assessment of such factors brings up a broader perspective on patient’s health problems [8]. Adjustment to the disease is important in many chronic diseases, which demand a change of the patient’s attitude and taking aspects such as acceptance of one’s disease into consideration [9]. The term ‘acceptance’ denotes adopting an opinion, judgment, belief, behavior, favorable attitude or to give a consent [10]. Accepting one’s disease means adjusting to limitations posed by it and accepting the associated disability. The consequences include accepting the limitations, not being self-sufficient, dependence on others and low self-esteem [11]. In a chronic and difficult therapeutic process, medical staff play the key role, in addition to other patient’s support. Bonding with other patients is an important regulating factor in the emotional sphere, while psychological counseling can turn out beneficial in accepting one’s new difficult life situation. The aim of the study was to evaluate the acceptance of the disease in patients with ulcerative colitis with respect to selected socio-demographic and clinical variables.
    Źródło:
    Polish Journal of Surgery; 2018, 90, 6; 6-12
    0032-373X
    2299-2847
    Pojawia się w:
    Polish Journal of Surgery
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Quality of Life Considering Patients with Chronic Inflammatory Bowel Diseases - Natural and Parenteral Nutrition
    Autorzy:
    Raczkowska, Aneta
    Ławiński, Michał
    Gradowska, Aleksandra
    Zielińska-Borkowska, Urszula
    Powiązania:
    https://bibliotekanauki.pl/articles/1395848.pdf
    Data publikacji:
    2014-12-18
    Wydawca:
    Index Copernicus International
    Tematy:
    Crohn's disease
    ulcerative colitis
    quality of life
    Opis:
    One of the elements of treatment considering inflammatory bowel diseases is nutritional therapy. The duration of the above-mentioned depends on the prevalence of such symptoms as fever, bowel move-ments, length of the functioning gastrointestinal tract, stoma and intestinal fistula presence. Nutritional therapy is an essential element of successful treatment alongside pharmacological, surgical, and biological therapy, as well as other methods. Crohn's disease and ulcerative colitis considered as chronic diseases, lead towards physical and biopsychosocial disability, being responsible for the reduction in the quality of life. The aim of the study was to determine the quality of life after surgical procedures in case of patients diagnosed with Crohn's disease and ulcerative colitis, subjected to natural and parenteral nutrition. Material and methods. The study group comprised 52 patients from the Department of Gastroen-terology, Military Medical Institute, and Department of Surgery and Clinical Nutrition, Clinical Hospital in Warsaw. The study was performed between October, 2011 and April, 2012. The World Health Organization Quality of Life Instrument - Bref (WHOQOL-BREF) questionnaire was used to deter-mine the patients’ quality of life. conclusions. A lower quality of life was observed in case of patients subjected to parenteral nutrition, poor education, disease symptoms exacerbation, in the majority-rural inhabitants. The quality of life does not depend on gender, type of disease, family status, and additional medical care.
    Źródło:
    Polish Journal of Surgery; 2014, 86, 9; 410-417
    0032-373X
    2299-2847
    Pojawia się w:
    Polish Journal of Surgery
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The Impact of the Nutritional State of Patients on the Results of the Surgical Treatment of Ulcerative Colitis
    Autorzy:
    Skowrońska-Piekarska, Urszula
    Matysiak, Konrad
    Sowińska, Anna
    Powiązania:
    https://bibliotekanauki.pl/articles/1396201.pdf
    Data publikacji:
    2013-08-01
    Wydawca:
    Index Copernicus International
    Tematy:
    ulcerative colitis
    nutritional assessment
    undernutrition
    surgery
    length of stay
    Opis:
    A variety of mechanisms have been proposed to explain the malnutrition and body mass loss in UC patients. The aim of the study trial was a nutritional state assessment of 347 UC patients, admitted for surgical treatment, and the evaluation of the impact of this state on the postoperative course in this group of patients. Material and methods. We referred the results of nutritional state assessment to the length of time of postoperative hospitalization of patients. Results. Through application of the Kruskal-Wallis test we found statistically significant, but weakly expressed, differences between the values of nutritional state parameters and period of hospitalization of patients. The applied U Mann-Whitney test, with statistically significant results with p <0.05, showed statistically significant differences between cured and dead subgroups in: 1) loss of body mass in 6 months before hospitalization (p = 0.000033), 2) hemoglobin level (p = 0.006676), 3) total lymphocyte count (TLC) (p = 0.025242), 4) total serum protein level (p = 0.003485), 5) serum albumin level (p =0.00165). Differences in BMI values were statistically negligible (p = 0.969397). Conclusions. The body mass loss in 6 months before admission, total lymphocyte count and serum albumin level are the reference parameters of the nutritional state of UC patients on admission to surgery
    Źródło:
    Polish Journal of Surgery; 2013, 85, 8; 424-432
    0032-373X
    2299-2847
    Pojawia się w:
    Polish Journal of Surgery
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Multifocal colorectal cancer in ulcerative colitis patient with sclerosing cholangitis – case report
    Autorzy:
    Kosmowska, Anna
    Krokowicz, Piotr
    Nelke, Marcin
    Powiązania:
    https://bibliotekanauki.pl/articles/1391810.pdf
    Data publikacji:
    2020
    Wydawca:
    Index Copernicus International
    Tematy:
    adenocarcinoma
    multifocal colorectal cancer
    primary sclerosing cholangitis
    ulcerative colitis
    Opis:
    Introduction: U lcerative colitis (CU) is an inflammatory disease predisposing to colorectal cancer. Colorectal cancer in ulcerative colitis is more often metachronous or synchronous. Case report: In this case report we present a patient with multifocal colorectal cancer in the course of CU and operative treatment that was implemented. Additionallyprimary sclerosing cholangitis was diagnosed in this patient post-operatively.
    Źródło:
    Polish Journal of Surgery; 2020, 92, 6; 51-54
    0032-373X
    2299-2847
    Pojawia się w:
    Polish Journal of Surgery
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Sexual activity in patients after proctocolectomy with ileal pouch-anal anastomosis
    Autorzy:
    Kluska, Piotr
    Dzika-Andrysiak, Katarzyna
    Mik, Michał
    Zelga, Piotr
    Włodarczyk, Marcin
    Kujawski, Ryszard
    Dziki, Łukasz
    Dziki, Adam
    Trzciński, Radzisław
    Powiązania:
    https://bibliotekanauki.pl/articles/1391528.pdf
    Data publikacji:
    2021
    Wydawca:
    Index Copernicus International
    Tematy:
    familial adenomatous polyposis
    quality of sexual life
    restorative proctocolectomy
    ulcerative colitis
    Opis:
    Introduction: Proctocolectomy with ileal pouch-anal anastomosis is the gold standard in the surgical treatment of patients with ulcerative colitis, familial adenomatous polyposis and other colorectal diseases requiring colectomy. The treatment consists in removing the large intestine and creating an intestinal reservoir from the last ileum loop and then anastomosing the intestinal reservoir with the anal canal. Like any surgical procedure, RPC-IPAA also carries the risk of complications, both early and late. Late postoperative complications include sexual dysfunction. Aim: The main goal of the following work is to assess the quality of life and sexual activity in patients having undergone the RPC-IPAA procedure at the General and Colorectal Surgery Clinic. Material and methods: The study group consisted of patients aged 19–79 who had been subjected to RPC-IPAA procedures at the General and Colorectal Surgery Clinic in years 2010–2019. The study was conducted on the basis of a survey consisting of 50 questions about the social and mental condition, medical history and previous treatment as well as the quality of sexual life before and after surgery. The scale used for the assessment of the quality of sex life consisted of 5 grades: very low, low, medium, high, very high. Thirty subjects (21 men and 9 women) took part in the survey. Ulcerative colitis (86.6%) was the most common reason for qualification for restorative proctectomy among the examined patients; less common reasons included familial adenomatous polyposis (13.3%) and synchronous colorectal cancer (3.3%). A vast majority of the surgeries had been performed after 10 years’ duration of ulcerative colitis, and the intestinal reservoir had been functioning for over a year at the time of the examination. In addition, the effect of taking steroids and the impact of early postoperative complications on the quality of sex life of patients was assessed. Results: High or very high sexual activity before surgery was reported by 46% of patients whereas low or very low quality was reported by 13%. The rest of the responders assessed their pre-operative sexual activity as average. After surgery, 23% of patients rated their sexual activity as high or very high while 36.6% of patients rated it as low or very low (P = 0.07). It was also noted that taking corticosteroids before surgery decreased the quality of sex life after surgery (P = 0.07 for activity, P = 0.04 for quality). None of the women surveyed used artificial moisturizing of intimate places during sex. Only 1 person stated that they started using artificial moisturization of intimate places after the procedure (P = 0.5). None of the men surveyed had used pharmacological agents to help them obtain an erection before surgery while as many as 33% of responders reported the need for their use after surgery (P = 0.008). Other postoperative sexual dysfunctions were also registered, such as dyspareunia (13.3%), sensory disorder within the intimate region, fecal incontinence, and urinary incontinence. Conclusions: To sum up, sexual activity and quality of sexual life deteriorated after RPC-IPAA in our patients.
    Źródło:
    Polish Journal of Surgery; 2021, 93, 1; 19-24
    0032-373X
    2299-2847
    Pojawia się w:
    Polish Journal of Surgery
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-6 z 6

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