- Tytuł:
- An association of the MCP-1 and CCR2 single nucleotide polymorphisms with colorectal cancer prevalence
- Autorzy:
-
Walczak, Anna
Przybyłowska-Sygut, Karolina
Sygut, Andrzej
Cieślak, Adrianna
Mik, Michał
Dziki, Łukasz
Dziki, Adam
Majsterek, Ireneusz - Powiązania:
- https://bibliotekanauki.pl/articles/1393280.pdf
- Data publikacji:
- 2017
- Wydawca:
- Index Copernicus International
- Tematy:
-
colorectal cancer
MCP-1
CCR-2
single nucleotide polymorphisms - Opis:
- The aim of the study: We evaluated the connection between the presence of the -2518 A/G MCP-1 as well as 190 G/A CCR2 polymorphic variants and colorectal cancer (CRC) occurrence. Material and methods: Study group consisted of subjects with different stages of CRC as well as healthy controls. Genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Results: W observed an association between the colorectal cancer and the GG genotype of the -2518 A/G MCP-1 single nucleotide polymorphism. No statistically significant correlation was found between CRC and the 190 G/A CCR2 polymorphism. Conclusion: The results of this study support the hypothesis that polymorphism in the MCP-1 gene may contribute to the etiology of colorectal cancer.
- Źródło:
-
Polish Journal of Surgery; 2017, 89, 5; 1-5
0032-373X
2299-2847 - Pojawia się w:
- Polish Journal of Surgery
- Dostawca treści:
- Biblioteka Nauki
Artykuł