- Tytuł:
- Complications of radio- and radiochemotherapy in patients undergoing major salivary gland cancer surgery
- Autorzy:
-
Kordzińska-Cisek, Izabela
Grzybowska-Szatkowska, Ludmiła - Powiązania:
- https://bibliotekanauki.pl/articles/1397794.pdf
- Data publikacji:
- 2019
- Wydawca:
- Index Copernicus International
- Tematy:
-
salivary gland tumours
radiotherapy
radiochemotherapy
radiation-induced reaction - Opis:
- Purpose: The aim of this retrospective study was to present the prevalence of early and late radiation-induced reaction and factors affecting its formation and severity in patients after adjuvant radio- or radiochemotherapy in salivary gland cancer. Material and methods: A total of 113 patients with early and 91 with late radiation-induced reaction, irradiated in 2006-2016 were enrolled in the study. The frequency of acute mucosal radiation-induced reaction, time of onset, intensity, healing time, as well as the incidence of late radiation-induced reaction from the skin and subcutaneous tissue were analyzed. Factors that could influence the development and intensity of reaction were identified. Results: Acute severity and the presence of late radiation-induced reaction do not affect overall survival. Dosage in the tumor bed site, as well as the dosage in the nodal region, affect the severity of the acute radiation-induced mucosal reaction. The severity of the early radiation-induced reaction is higher in men, more advanced patients (higher T and N+ in TNM classification), irradiated into a larger area, and those in whom two-dimensional planning and complementary chemoradiotherapy were applied. The late reaction of the skin and subcutaneous tissue was dominated by patients irradiated in the nodal regions and those with a higher intensity of early radiation-induced reaction. Conclusions: Supplementary radiotherapy or radiochemotherapy in salivary gland cancer is associated with acceptable toxicity which has no effect on overall survival.
- Źródło:
-
Polish Journal of Otolaryngology; 2019, 73, 3; 26-31
0030-6657
2300-8423 - Pojawia się w:
- Polish Journal of Otolaryngology
- Dostawca treści:
- Biblioteka Nauki
Artykuł