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    Wyświetlanie 1-12 z 12
    Tytuł:
    Report from the analysis of implementiation of 4th Head and Neck Cancer Awareness Week in Department of Otolaryngology in Międzyleski Hospital in Warsaw
    Autorzy:
    Dżaman, Karolina
    Piskadło–Zborowska, Karolina
    Pietniczka–Załęska, Mirosława
    Powiązania:
    https://bibliotekanauki.pl/articles/1398499.pdf
    Data publikacji:
    2017
    Wydawca:
    Index Copernicus International
    Tematy:
    European Head and Neck Cancer Awareness Week
    head and neck tumors
    Opis:
    Introduction: The aim of the study was to analyze the profile of patients who reported for free screening examinations during the 4th European Head and Neck Cancer Awareness Week to the Department of Otolaryngology, Miedzylesie Specialist Hospital, Warsaw, Poland. Material and methods: We enrolled 225 patients, aged 26-92 years (mean, 63 years). There were 149 women (66%) and 76 men (34%). All patients filled out a survey regarding risk factors of head and neck cancer (HNC), including symptoms and lifestyle characteristics. Subsequently, all participants underwent a complete laryngological examination. Results: Among the studied patients, we found the following lifestyle-related risk factors of HNC: tobacco use (22%), alcohol use more than 1 time per week (12%), oral sex (17%), multiple sexual partners (10%), rare dental checkups (24%), and dental prostheses (45%). The most frequent symptoms that prompted the patients to report for screening exams were as follows: chronic hoarseness (64%), xerostomia (39%), dysphagia (37%), nasal congestion (6%), and neck tumor (5%). Further imaging studies were ordered in 15 patients (7%), fiberoscopy in 25 (11%), and lesion excision in 18 (8%). Among the studied patients, 17 were referred for further oncological treatment, of whom 14 had benign tumors and 4 malignant tumors. Conclusions: The Head and Neck Cancer Awareness campaign increased the awareness of HNC, and it should systematically encompass people at increased risk. By implementing this program in our department, we were able to detect and initiate early treatment in 7.5% of the screened people. However, appropriate workup and treatment require funding and therefore systemic measures should be taken to enable a wide implementation of such screening programs.
    Źródło:
    Polish Journal of Otolaryngology; 2017, 71, 6; 35-39
    0030-6657
    2300-8423
    Pojawia się w:
    Polish Journal of Otolaryngology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Clinical manifestation of malignant lymphomas of the head and neck region
    Autorzy:
    Bojanowska-Poźniak, Katarzyna
    Nurkowska, Monika
    Danilewicz, Marian
    Pietruszewska, Wioletta
    Powiązania:
    https://bibliotekanauki.pl/articles/1398500.pdf
    Data publikacji:
    2017
    Wydawca:
    Index Copernicus International
    Tematy:
    malignant lymphoma
    head and neck neoplasm
    extranodal lymphoma
    Opis:
    Introduction: Malignant lymphoma (ML) is a neoplasm caused by clonal expansion of undifferentiated B, T and NK-lymphoid cells. WHO classification divides lymphomas into two main types, i.e. Hodgkin lymphoma (HL), and non-Hodgkin lymphoma (NHL), with numerous subtypes. The majority of MLs are localized in lymph nodes, but extranodal locations are also possible. MLs represent approximately 3-5% of all malignant neoplasms in Poland, but their incidence has been increasing in recent years, especially in young patients. The objective of the study was to evaluate clinical manifestations and diagnostic process in patients with malignant lymphomas of the head and neck region as diagnosed in the Department of Otorhinolaryngology of the Medical University of Lodz in years 2013-2017. Material and method: 30 patients diagnosed with malignant lymphomas of the head and neck region at the Departbadament of Otorhinolaryngology of the Medical University of Lodz in 2013-2017. Results: The study group consisted of 8 cases of nodal lymphomas and 22 cases of extranodal lymphomas. In 29 cases B-cell lymphomas were diagnosed. The most common symptoms included lymphadenopathy or neck tumor. Other symptoms were associated with the location of tumors in particular body organs. The diagnosis was based on histopathological examination of biopsy (needle or surgical) samples. Conclusion: Malignant lymphomas should be taken into account during differential diagnosis of the tumor or lymphadenopathy of the neck. The diagnosis is difficult because of the nonspecificity of symptoms and the need for interdisciplinary cooperation of many specialists.
    Źródło:
    Polish Journal of Otolaryngology; 2017, 71, 6; 14-21
    0030-6657
    2300-8423
    Pojawia się w:
    Polish Journal of Otolaryngology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Effect of copper(II) the activity of glutathione peroxidase in patients with head and neck cancer
    Autorzy:
    Malinowska, Katarzyna
    Morawiec-Sztandera, Alina
    Majsterek, Ireneusz
    Kaczmarczyk, Dariusz
    Powiązania:
    https://bibliotekanauki.pl/articles/1398625.pdf
    Data publikacji:
    2016
    Wydawca:
    Index Copernicus International
    Tematy:
    pyrazole complex
    glutathione peroxidase
    head and neck cancer
    Opis:
    Introduction: Head and neck squamous cell carcinoma (HNSCC) accounts for about 6% of all malignant cancers. In the epidemiology of oral cavity neoplasm, important risk factors include: tobacco smoking, alcohol abuse, bad oral hygiene, papilloma virus infection, riboflavin and iron deficiency. Objective: The objective of the investigation was a synthesis of Cu(II) complex and the evaluation of antioxidative enzymatic barrier in red blood cells of patients with head and neck tumor as well as in the control group. Materials and methods: For the investigation conduction, a consent of Bioethics Committee number RNN/142/09/KB was obtained. Blood for the examination was obtained from the patients of the Dapartment of Head and Neck Neoplasms Surgery Medical University of Łódź. The experiment was conducted on the group of 40 patients with HNSCC and 40 healthy people, using spectrophotometric method, glutathione peroxidase was marked. Results: The investigation was conducted on the hemolysate obtained from the patients that were divided into two groups – a study group (1 and 2), which consisted of patients diagnosed with head and neck cancer and a control group (1 and 2) – healthy people. A significant statistical result for GPX occurred in control-1 and study-1 group with complex compound Cu(II) (p<0,001). Conclusions: Presented research prove, that complex compound Cis-dichlorobis(N1-hydroxymethyl-3methylpyrazole-κN2)copper (II) has an impact on the activity of the antioxidative GPX enzyme.
    Źródło:
    Polish Journal of Otolaryngology; 2016, 70, 6; 20-25
    0030-6657
    2300-8423
    Pojawia się w:
    Polish Journal of Otolaryngology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Comparison of criteria for elective tracheostomy in head and neck cancer surgery
    Autorzy:
    Kissin, Filip
    Rysz, Maciej
    Budziszewska, Magdalena
    Krajewski, Romuald
    Powiązania:
    https://bibliotekanauki.pl/articles/1397292.pdf
    Data publikacji:
    2021
    Wydawca:
    Index Copernicus International
    Tematy:
    elective tracheostomy
    head and neck surgery
    postoperative complications
    Opis:
    Elective tracheostomy before resection of a malignancy in head and neck region assures unobstructed ventilation during postoperative period but is associated with an increased risk of complications. We aimed to evaluate retrospectively, how the application of elective tracheostomy scales would influence the frequency of tracheostomy in comparison with preoperative clinical judgement. In 205 patients operated on from 2013 till 2017, theresection of a malignancy involved suprahyoid or pharyngeal muscles, neck dissection and flap reconstruction. The decision on elective tracheostomy was made on the clinical basis. Score for each patient in 3 published scales was calculated. In the study group 76 patients had elective tracheostomy at the outset of a resection procedure. Among 129 patients without elective tracheostomy, 9 had tracheostomy in the postoperative period. Indications for elective tracheostomy were calculated for scale I, II and III. Only in 120 patients the decision whether to perform elective tracheostomy would be identical in each scale. Our results suggest that decisions to perform elective tracheostomy based on 3 scales show low specificity. The factors used in the published scales should be evaluated in a prospective multicenter study
    Źródło:
    Polish Journal of Otolaryngology; 2021, 75, 4; 20-26
    0030-6657
    2300-8423
    Pojawia się w:
    Polish Journal of Otolaryngology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The influence of age and comorbidities on the outcomes of surgical treatment with free tissue transfer: a retrospective study
    Autorzy:
    Czesak, Małgorzata
    Sobol, Maria
    Bruzgielewicz, Antoni
    Niemczyk, Kazimierz
    Osuch-Wójcikiewicz, Ewa
    Powiązania:
    https://bibliotekanauki.pl/articles/1397380.pdf
    Data publikacji:
    2020
    Wydawca:
    Index Copernicus International
    Tematy:
    elderly patient
    head and neck cancer
    reconstructive surgery
    Opis:
    Introduction: Microvascular free tissue transfer enables the reconstruction of complex head and neck defects. The aim of the study was to assess the results of treatment of patients undergoing reconstructive surgery and to identify factors affecting these results, with particular reference to patient’s age. Materials and Methods: All patients who underwent free-flap head and neck reconstruction in our institution between 2010 and 2017 were included in this retrospective study. A series of 66 patients met the inclusion criteria and were divided into 2 age groups: group G1 aged <65 years (n = 41) and group G2 aged ≥65 years (n = 25). Minor local complications and general complications as well as comorbidities were analyzed. Results: No correlation was found between advanced age and the risk of free flap failure as well as the incidence of local minor complications. General complications were more frequent in the G2 group (32%) than in the G1 group (19.5%), although this is not a statistically significant difference. A statistically significant difference was found between the age and the patient’s health status according to ASA (P = 0.010). In the younger low-risk group, 12 patients (29.3%) had general and local complications, while in the older low-risk group only 1 (4%). General and local complications were found in 5 (12.2%) high-risk G1 patients and in 7 (28%) high-risk G2 patients. Conclusion(s): Patients with advanced head and neck malignant tumors should undergo reconstructive microsurgery regardless of age.
    Źródło:
    Polish Journal of Otolaryngology; 2020, 74, 4; 8-12
    0030-6657
    2300-8423
    Pojawia się w:
    Polish Journal of Otolaryngology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The impact of radiotherapy on the quality of life in patients with early-stage clinical head and neck cancer
    Autorzy:
    Milecki, Jakub
    Żmijewska-Tomczak, Małgorzata
    Osmola, Krzysztof
    Wierzbicka, Małgorzata
    Powiązania:
    https://bibliotekanauki.pl/articles/23203207.pdf
    Data publikacji:
    2021-05-07
    Wydawca:
    Index Copernicus International
    Tematy:
    head and neck cancer
    Quality of life
    radiotherapy
    Opis:
    Introduction: Radiotherapy (RT) for patients with head and neck squamous cell carcinoma (HNSCC) affects vital functions related to the irradiation volume of the head and neck region and, in addition, has a negative impact on social functioning, thereby significantly impairing patients’ quality of life (QoL). Aim: The aim of this study was to assess changes in the quality of life in patients with head and neck cancer treated with curative RT at 12 months after completion of RT. The aim of this study was to assess the differences between the baseline QoL of patients with early clinical stage HNSCC and at 12 months after curative/radical RT. Material and methods: The prospective clinical study included 92 patients in good general condition (ECOG 0–1 – Eastern Cooperative Oncology Group performance status), without regional or distant metastases, diagnosed with pathomorphologically confirmed early-stage head and neck squamous cell carcinoma treated with definitive RT. All patients participating in the study signed an informed consent form. QoL was assessed using the standard EORTC QLQ-C30 and QLQH&N35 questionnaires. In addition, information on clinical aspects and data relating to socio-demographic factors were obtained from each patient. Statistical analysis was performed using a statistical package (SPSS 17.0). T-test was used for dependent and independent samples. A general linear model was used for repeated measures. Results: Patients’ QoL deteriorated significantly after definitive RT. Worse QoL Core-30 scores in patients 12 months after the end of RT, compared with baseline QoL, before the start of RT, were observed in domains such as physical performance, fulfillment of life roles, cognitive functioning, loss of appetite, fatigue and constipation. For the QLQ-H&N35 questionnaires, patients 12 months after the end of RT reported problems in relation to aspects of life such as senses, mouth opening, dry mouth, thick saliva, pain, and weight loss. Conclusion: RT, even in early clinical stage head and neck cancer, has a negative impact on QoL, despite modern treatment techniques.
    Źródło:
    Polish Journal of Otolaryngology; 2021, 75, 5; 1-8
    0030-6657
    2300-8423
    Pojawia się w:
    Polish Journal of Otolaryngology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Updated National Comprehensive Cancer Network guidelines for treatment of head and neck cancers 2010-2017
    Autorzy:
    Wierzbicka, Małgorzata
    Napierała, Joanna
    Powiązania:
    https://bibliotekanauki.pl/articles/1398501.pdf
    Data publikacji:
    2017
    Wydawca:
    Index Copernicus International
    Tematy:
    head and neck cancers treatment guidelines
    biological therapy
    personalized treatment
    recommendations
    Opis:
    Introduction: The diagnostic and therapeutic recommendations have been changing over the years to improve treatment outcomes and quality of life of Head and Neck Cancer (HNC) patients. Aim: The aim of this study was to present currently recommended Head and Neck Cancer treatment guidelines based on the literature review with particular emphasis on novel approaches the NCCN algorithms. Material and methods: The review of literature covering articles published in the last five years and pointing out essential changes in HNC treatment regarding evidence based medicine. The study focused on the analysis of novel approaches for the particular primaries, the implementation of biological therapies and personalized cancer therapies. Results: Updates in the oncological NCCN guidelines for all ENT primaries except major salivary glands and subglottis are based on knowledge derived from the basic sciences, clinical trials and the best evidence available currently. The latest recommendations emphasize value of biological therapies use.
    Źródło:
    Polish Journal of Otolaryngology; 2017, 71, 6; 1-6
    0030-6657
    2300-8423
    Pojawia się w:
    Polish Journal of Otolaryngology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Health-related quality of life in oropharyngeal cancer survivors – a population-based study
    Autorzy:
    Guenzel, Thomas
    Walliczek-Dworschak, U
    Teymoortash, A
    Singer, S
    Eichler, M
    Wilhelm, T
    Schimmer, M
    Franzen, A
    Powiązania:
    https://bibliotekanauki.pl/articles/1398253.pdf
    Data publikacji:
    2018
    Wydawca:
    Index Copernicus International
    Tematy:
    EORTC
    oropharynx
    tonsil
    tongue
    cancer
    head and neck
    quality of life
    Opis:
    Objective: The aim of this study was to compare QoL of oropharyngeal cancer survivors who had received different treatments. Subjects and methods: We contacted 954 survivors. Each survivor received the QoL questionnaires EORTC QLQ-C30 and EORTC QLQ-H&N35. Results: A total of 263 survivors completed the questionnaires (28% responses). Forty-five of them had undergone surgery, 20 had received definitive radiotherapy or chemo-radiotherapy, 85 surgery plus adjuvant radiotherapy, and 111 surgery plus adjuvant chemo-radiotherapy. Survivors who had received adjuvant radiotherapy and surgery reported significantly more problems with swallowing (B=13.43 [95% Confidence Interval (CI) 1.83-25.03]), senses (B=24,91 [CI 11.86-37.97]), eating (B=16.91 [CI 3.46-30.36]), dry mouth (B=26.42 [CI 12.17-40.67]), sticky saliva (B=22.37 [CI 6.23-38.50]) and nutritional supplements (B=18.59 [CI 0.62-36.56]) than those who had received surgery only. Survivors who had received adjuvant chemo-radiotherapy and surgery reported significantly many more problems with dry mouth (B=34.15 [CI 18.91-49.39]) and sticky saliva (B=22.90 [CI 5.65-40.16]), and fewer problems with physical functioning (B=-12.07 [CI 0.49-23-64]). Conclusion: Survivors who participated in this survey and who had undergone surgery alone reported in some head- and neck-specific domains a better health-related quality of life than patients who had undergone multi-modal treatment or adjuvant radiotherapy.
    Źródło:
    Polish Journal of Otolaryngology; 2018, 72, 2; 30-35
    0030-6657
    2300-8423
    Pojawia się w:
    Polish Journal of Otolaryngology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Retrospective evaluation of risk factors for oral cavity and oropharynx cancers in patients under the program of head and neck cancers prevention
    Autorzy:
    Kowalski, Andrzej
    Olszewski, Jurek
    Zielińska-Bliźniewska, Hanna
    Powiązania:
    https://bibliotekanauki.pl/articles/1397748.pdf
    Data publikacji:
    2019
    Wydawca:
    Index Copernicus International
    Tematy:
    Head and Neck Cancer Prophylaxis Program
    oral cavity
    oropharynx cancer
    risk factors
    Opis:
    Introduction: The aim of the study was to analyze the risk factors for oral cavity and pharyngeal cancer in people examined under the Head and Neck Cancer Prophylaxis Program. Material and methods: The study was conducted in a total of 300 patients, including 186 women and 114 men, as part of the Head and Neck Cancer Prevention Program in 2014–2018. Before the laryngological examination, the patients completed a demographic and medical questionnaire regarding the risk factors of head and neck cancer, including education, reported disease symptoms, smoking addiction, number of cigarettes smoked daily, alcohol consumption, frequency of visits in a dental office, oral hygiene measures, number of sexual partners, oral sex, family medical history of head and neck cancer. Results: The subjects reported the following symptoms: hoarseness 43.33%, difficulty swallowing 21.33%, pain or mouth burning 20.33% and other symptoms were observed in 46.33%. The main dental symptoms were: bleeding from the gums during teeth brushing in 48.89%, dry mouth 45.56%. Currently 20.33% of respondents smoke, whereas 54% of patients smoked in the past. In the analyzed material, the majority (80%) consumed alcoholic beverages. 27.67% of respondents admitted having oral sex, including 24.73% of women and 32.46% of men. After performing the extended diagnostics, the tumor was found in 10% of the subjects. C onclusions: Statistical significance of differences was found: between hoarseness and alcohol consumption, both in women and in men, between hoarseness and smoking in women, between difficulty in swallowing and smoking in women, between burning/pain in the mouth and smoking in men, between hoarseness and the cultivation of oral sex in men, between the difficulty of swallowing and the practice of oral sex in the studied men and between burning/pain in the oral cavity and the occurrence of malignancy.
    Źródło:
    Polish Journal of Otolaryngology; 2019, 73, 6; 24-31
    0030-6657
    2300-8423
    Pojawia się w:
    Polish Journal of Otolaryngology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Immunotherapy of head and neck squamous cell carcinoma (HNSCC). Immune checkpoint blockade
    Autorzy:
    Przybylski, Krzysztof
    Majchrzak, Ewa
    Weselik, Liucija
    Golusiński, Wojciech
    Powiązania:
    https://bibliotekanauki.pl/articles/1398281.pdf
    Data publikacji:
    2018
    Wydawca:
    Index Copernicus International
    Tematy:
    head and neck squamouscell carcinoma
    immunotherapy
    CTLA - 4
    PD - 1
    nivolumab
    pembrolizumab
    Opis:
    Treating patients with squamous cell carcinoma of the head and neck is a significant problem. There is an increase in the incidence of malignant neoplasms in this region. Surgery, radiotherapy and chemotherapy are often not sufficient methods of treatment. Thorough analysis of processes occurring in the tumor microenvironment has allowed to distinguish three stages that make up the reaction of the human body to hostile antigens, which are tumor antigens. Understanding these mechanisms has resulted in the introduction of a new term immune-oncology. It is an area of cancer treatment that focuses on use of the patient’s immune system to combat the disease. Immunotherapy has had positive effects in cancer patients. The use of immune checkpoint inhibitors, such as anti-CTLA-4 and PD-1 monoclonal antibodies has enabled the modulation of T cell functions, consequently eliminating immunosuppression in the tumor microenvironment. Clinical trials were conducted using nivolumab and ipilimumab, which confirmed their clinical usefulness. The approval by FDA of nivolumab in treatment of recurrent and metastatic squamous cell carcinoma of the head and neck has increased the overall survival time of patients as well as disease free survival. Statistical data indicate an advantage of immunotherapy over other treatment methods at an advanced stage of cancer. This work aims to discuss basic issues related to immunotherapy, in particular immunotherapy in patients with squamous cell carcinoma of the head and neck.
    Źródło:
    Polish Journal of Otolaryngology; 2018, 72, 6; 10-16
    0030-6657
    2300-8423
    Pojawia się w:
    Polish Journal of Otolaryngology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Virtual surgical planning and cone beam computed tomography in reconstruction of head and neck tumors – pilot study
    Autorzy:
    Krakowczyk, Łukasz
    Piotrowska-Seweryn, Agnieszka
    Szymczyk, Cezary
    Wierzgoń, Janusz
    Oleś, Krzysztof
    Ulczok, Rafał
    Donocik, Karolina
    Dowgierd, Krzysztof
    Maciejewski, Adam
    Powiązania:
    https://bibliotekanauki.pl/articles/1397270.pdf
    Data publikacji:
    2021
    Wydawca:
    Index Copernicus International
    Tematy:
    cone beam computed tomography
    free flap
    head and neck
    reconstruction
    virtual surgical planning
    Opis:
    Introduction: The aim of the study was to prove that a combination of visual surgical planning (VSP) and cone beam computed tomography (CBCT) is an optimal technique in fibular free flap reconstructions after complex tumor resections in the head and neck region and that it leads to better functional and aesthetic outcomes. Material and method: Six patients (3 females, 3 males) with head and neck tumors were included in the study. The region concerned midface in 2 cases and mandible in 4 patients. On the basis of computed tomography of the head, fibular free flap (FFF) reconstruction was planned with the VSP technique. The 3D-printed models were prepared. At the beginning of the operation and a few minutes after the reconstruction, an xCAT CBCT by XORAN was performed. Minor corrections of the angles of the reconstructed bony parts were made where needed. The time of the operation was assessed for each case. Functional and cosmetic results were evaluated in a 1-year follow-up. Results: The mean time of operation was 6 hours and 48 minutes, which was approximately 1hour and 40 minutes less than standard reconstructive surgery. Functional recovery was achieved in all patients. Aesthetic result was unsatisfactory for 2 patients due to insufficient soft tissue masses of FFF. Conclusions: The authors claim that intraoperative CBCT imaging, regardless of the cost, improves the accuracy of aesthetic outcome of reconstructive surgeries based on VSP, especially in the region of the midface and the mandible. Further studies on a higher number of subjects are required.
    Źródło:
    Polish Journal of Otolaryngology; 2021, 75, 2; 28-33
    0030-6657
    2300-8423
    Pojawia się w:
    Polish Journal of Otolaryngology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Antioxidative assessment of new trans-palladium (II) complexes in head and neck cancer
    Autorzy:
    Malinowska, Katarzyna
    Kaczmarczyk, Dariusz
    Zajdel, Radosław
    Merecz-Sadowska, Anna
    Olszewski, Jurek
    Majczyk, Małgorzata
    Nowak-Zduńczyk, Alicja
    Zielińska-Bliźniewska, Hanna
    Powiązania:
    https://bibliotekanauki.pl/articles/1397298.pdf
    Data publikacji:
    2020
    Wydawca:
    Index Copernicus International
    Tematy:
    antioxidant enzymes
    head and neck cancer
    oxidative stress
    Pd (II) complexes
    reactive oxygen species
    Opis:
    Background: Head and neck neoplasms stand for 6% of all malignant neoplasms worldwide. Chemotherapy has limited use due to the biological properties of the tumor (in the majority of cases moderately and poorly differentiated squamous cell carcinoma). The fundamental molecule used in treatment is cisplatin and its derivates, that can be associated with fluorouracil. The new chemotherapeutic agents are not in common use during the treatment of head and neck malignancies. However, the use of low molecular weight complexes Pd (II) carries the potential of being more effective in therapy. Material and Methods: Fifty-one patients, 30 men and 21 women (aged 52.9 ± 12.1 years) with head and neck cancer were included in the study. Fifty-one healthy subjects, 31 men and 20 women, (aged 54.1 ± 14.7 years) years formed the control group. Antioxidant enzymes, superoxide dismutase, and catalase activities in erythrocytes were examined. Results: An increased level of antioxidant enzymes was seen in the blood samples from patients with head and neck cancer after incubation with Pd (II) complex. In the group we obtained a statistically significant result p = <0.001. Discussion: That project may contribute to the development of new, more efficient head and neck cancer treatment strategies. In our opinion, the results can be used in the future to develop a valuable prognostic marker of the disease. This is important because the initial phase of cancer is asymptomatic. The search for factors involved in pathogenesis translates into economic benefits and makes therapy more effectiveness through the reduction of treatment expenses.
    Źródło:
    Polish Journal of Otolaryngology; 2020, 74, 1; 23-28
    0030-6657
    2300-8423
    Pojawia się w:
    Polish Journal of Otolaryngology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-12 z 12

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