- Tytuł:
- Effects of processing parameters on the properties of amphiphilic block copolymer micelles prepared by supercritical carbon dioxide evaporation method
- Autorzy:
-
Jiao, Z.
Wang, Z.
Wang, X.
Fan, W. - Powiązania:
- https://bibliotekanauki.pl/articles/778902.pdf
- Data publikacji:
- 2018
- Wydawca:
- Zachodniopomorski Uniwersytet Technologiczny w Szczecinie. Wydawnictwo Uczelniane ZUT w Szczecinie
- Tematy:
-
supercritical carbon dioxide
amphiphilic block copolymer
drug-loaded micelles
processing parameters
optimization - Opis:
- The operation parameters for the supercritical carbon dioxide (ScCO2 ) evaporation method greatly affect the properties of the prepared drug-loaded micelles. In this study, the effects of those key parameters on the drug-loading content (LC) and drug entrapment efficiency (EE) are discussed. It is observed that EE and LC of the micelles are slightly increased with the enhancing temperature and the copolymer molecular ratio of hydrophilic/hydrophobic segment, while decreased with the enhancing ScCO2 evaporation rate. The pressure and volume ratio of ScCO2 to H2 O are observed the optimum condition. In addition, the verification experiment is carried out under the obtained optimizing parameters. The prepared micelles exhibit relatively regular spherical shape and narrow size distribution with the EE and LC value of 70.7% and 14.1%, respectively.
- Źródło:
-
Polish Journal of Chemical Technology; 2018, 20, 1; 81-86
1509-8117
1899-4741 - Pojawia się w:
- Polish Journal of Chemical Technology
- Dostawca treści:
- Biblioteka Nauki
Artykuł