- Tytuł:
- Antinociceptive effect of MAS MT in rats
- Autorzy:
-
Rykaczewska-Czerwinska, M.
Radosz, A.
Szymanowska-Dziubasik, K.
Konopinska, D.
Plech, A. - Powiązania:
- https://bibliotekanauki.pl/articles/55342.pdf
- Data publikacji:
- 2008
- Wydawca:
- Sieć Badawcza Łukasiewicz - Instytut Przemysłu Organicznego
- Tematy:
-
Tenebrio molitor
antinociceptive effect
rat
larva
brain
neuropeptide
insect neuropeptide
Manduca sexta
proctolin
myotropin
biological activity
peptide chain
peptide - Opis:
- MAS MT is a myotropic decapeptide isolated from Manduca sexta. This peptide exerts stimulatory effect on insects heart-beat frequency. The present study was undertaken in order to determine a probable antinociceptive effect in rats of native synthetic decapeptide, MAS MT-I and its two analogs, heptapeptides MAS MT-II and MAS MT-III. All these peptides were applied directly into the lateral brain ventricle (icv) at three doses: 10, 25 and 50 nmol. The analgesic (antinociceptive) effect was evaluated by a tail immersion test. It was found that two doses of MAS MT-I: 25 and 50 nmol induced significant antinociceptive effect, while MAS MT-II and MAS MT-III exert a less antinociceptive effect in comparison with native MAS MT-I. Prior icv administration of naloxone, an opioid antagonist weakly blocked MAS MT-I effect. We conclude that antinociceptive effect of MAS MT-I in rats is not mediated by central opioid system.
- Źródło:
-
Pestycydy; 2008, 3-4; 139-146
0208-8703 - Pojawia się w:
- Pestycydy
- Dostawca treści:
- Biblioteka Nauki
Artykuł