- Tytuł:
-
Własności Przeciwarytmiczne I Hypotensyjne Nowych Analogów Teofiliny
Antiarrhythmic and Hypotensive Activity of New Analogues of Theophylline - Autorzy:
-
Sapa, Jacek
Zygmunt, Małgorzata
Krawczyk, Łukasz
Dudek, Magdalena
Bednarski, Marek
Nowiński, Leszek
Knutelska, Joanna
Chłoń-Rzepa, Grażyna
Pawłowski, Maciej - Powiązania:
- https://bibliotekanauki.pl/articles/1034048.pdf
- Data publikacji:
- 2013
- Wydawca:
- Zakład Opieki Zdrowotnej Ośrodek Umea Shinoda-Kuracejo
- Tematy:
-
hypotensive activity
theophylline antiarrhythmic activity - Opis:
- On the basis of our earlier studies in the group of 7,8-disubstituted derivatives of 1,3-dimetyl-3,7-dihydro-purine-2,6-dione, some new derivatives of theophylline were synthesized and tested for their electrocardiographic, antiarrhythmic and hypotensive activity as well as for α1-adrenoreceptor affinities. The performed preliminary tests indicated that new compounds did not significantly affect the normal ECG in vivo. As the result of present studies it may be concluded that all compounds did not possess hypotensive and arrhythmic activity. The results of the binding assays on α1-adrenergic receptors showed, that these derivatives display no affinity for α1-adrenergic receptors. Lack of antiarrhythmic and antihypertensive activity may result from the absence of affinity for the α1-adrenergic receptor. Performed chemical modifications lead to the loss of pharmacological activity previously observed among other derivatives in this group. Generally in comparison with the previously reported derivatives, replacing the phenoxyethylpiperazine by other moiety, changed the antiarrhythmic and hypotensive activity.
- Źródło:
-
Medicina Internacia Revuo; 2013, 25, 100; 128-135
0465-5435 - Pojawia się w:
- Medicina Internacia Revuo
- Dostawca treści:
- Biblioteka Nauki
Artykuł