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    Wyświetlanie 1-2 z 2
    Tytuł:
    Pathophysiological mechanisms and pharmacological methods of prevention and treatment of bronchopulmonary dysplasia in preterm infants
    Autorzy:
    Watroba, S.J.
    Bryda, J.
    Powiązania:
    https://bibliotekanauki.pl/articles/2099028.pdf
    Data publikacji:
    2019
    Wydawca:
    Instytut Medycyny Wsi
    Tematy:
    bronchopulmonary dysplasia
    preterm infants
    steroids
    mechanical ventilation
    metalloproteinases
    respiratory failure
    Opis:
    Introduction. Bronchopulmonary dysplasia (BPD) is a respiratory disease that is characterized by long-term respiratory failure and mainly affects premature infants with low birth weight (LBW), undergoing mechanical ventilation (MV) or requiring long-term oxygen therapy. In Europe, among newborns with birth weight <1500g, the incidence of BPD is around 15%. Objective. The purpose of this review was to analyze the pathophysiological mechanisms involved in the development of BPD in premature newborns and to discuss the current possibilities of pharmacological prevention and treatment of BPD. Description of the state of knowledge. The BPD pathogenesis is multifactorial. Lung damage is the result of barotrauma and volutrauma due to high-performance MV, actions of reactive oxygen species (ROS) and infectious agents. Currently used methods of pharmacological treatment of severe forms of BPD are mainly based on systemic steroid therapy and can not be considered completely effective and free of side effects. Conclusion. Despite the widespread use of proper pharmacotherapy and dynamic development of new methods of respiratory therapy, mortality in BPD is estimated at around 10% – 20%. Infants with BPD are much more exposed to respiratory infections caused by respiratory syncytial virus (RSV), which may result in the development of bronchial hyperresponsiveness and bronchial asthma. Among children with BPD there are significantly higher cognitive and behavioral deficits compared to healthy children, and cerebral palsy is also significantly more common.
    Źródło:
    Journal of Pre-Clinical and Clinical Research; 2019, 13, 4; 170-178
    1898-2395
    Pojawia się w:
    Journal of Pre-Clinical and Clinical Research
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Oral epithelial dysplasia and oral cancer prevalence in routine white lesion biopsies - a 6-year retrospective study
    Autorzy:
    Kuzio, M.
    Wapniarska, K.
    Danilewicz, M.
    Lewkowicz, N.
    Powiązania:
    https://bibliotekanauki.pl/articles/2097730.pdf
    Data publikacji:
    2020
    Wydawca:
    Instytut Medycyny Wsi
    Tematy:
    oral lichen planus
    oral cancer
    leukoplakia
    oral epithelial dysplasia
    frictional keratosis
    Opis:
    Introduction. Leukoplakia and oral lichen planus (OLP) are common diseases manifesting as white lesions that are considered potentially malignant disorders (PMD). Epithelial dysplasia may be an early sign of potency for the future transformation into oral squamous cell carcinoma (OSCC). A routine biopsy and close observation are recommended for persistent white oral lesions. As frictional keratosis may mimic oral leukoplakia, the question arises:Is there a need for a biopsy of persistent white lesion of traumatic origin? Materials and methods. Data from 643 oral tissue biopsies were retrospectively analyzed. A total of 176 (27.37%) results with provisional diagnosis of leukoplakia (36 cases), OLP (77 cases) and frictional keratosis (63 cases) were selected. Retrospective data collected included age, gender, smoking status, provisional and histopathological diagnosis. The data was analyzed to assess the prevalence of epithelial dysplasia and OSCC in terms of age, gender and smoking status. Results. Five (2.84%) cases of OSSC were reported, all of them were graded as G1; four cases of OSCC were found in clinically defined leukoplakia lesions; one case of OSCC (1.3%) was found in OLP biopsy; epithelial dysplasia was reported in 5 lesions (2.84%) provisionally diagnosed as OLP (3 cases), and leukoplakia in 2 cases. No dysplasia or OSCC were found in the lesions diagnosed as frictional keratosis. Conclusions. Epithelial dysplasia and OSCC may be found in leukoplakia or OLP lesions not initially suspected of any malignancy. In some cases, clinical features are not sufficient to diagnose a lesion without histopathology. Frictional keratosis is easily identified by clinicians, and may not require a biopsy in every case. Clinical and histopathological evaluation of the white lesions still needs improvement.
    Źródło:
    Journal of Pre-Clinical and Clinical Research; 2020, 14, 3; 63-68
    1898-2395
    Pojawia się w:
    Journal of Pre-Clinical and Clinical Research
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-2 z 2

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