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Tytuł:: Alantolactone and isoalantolactone suppress maximal electroshock-induced tonic seizures in mice
Autorzy:: Luszczki, J.J.
Marzeda, E.
Kondrat-Wrobel, M.W.
Florek-Luszczki, M.
Powiązania:: https://bibliotekanauki.pl/articles/3044.pdf
Data publikacji:: 2014
Wydawca:: Instytut Medycyny Wsi
Tematy:: alantolactone
isoalantolactone
electroshock-induced tonic seizure
seizure
mice
mouse
treatment
Źródło:: Journal of Pre-Clinical and Clinical Research; 2014, 08, 1
1898-2395
Pojawia się w:: Journal of Pre-Clinical and Clinical Research
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 2.

Tytuł:: Interactions of levetiracetam with ethosuximide in the mouse 6 Hz psychomotor seizure model - a type II isobolographic analysis
Autorzy:: Luszczki, J.J.
Wlaz, A.
Kondrat-Wrobel, M.W.
Pyrka, D.
Florek-Luszczki, M.
Powiązania:: https://bibliotekanauki.pl/articles/3145.pdf
Data publikacji:: 2014
Wydawca:: Instytut Medycyny Wsi
Tematy:: 6 Hz psychomotor seizure model
antiepileptic drug
drug interaction
ethosuximide
levetiracetam
isobolographic analysis
Opis:: The aim of the present study was to characterize the anticonvulsant effects of levetiracetam in combination with ethosuximide in the mouse 6 Hz psychomotor seizure model. Limbic (psychomotor) seizure activity was evoked in albino Swiss mice by a current (32 mA, 6 Hz, 3 s stimulus duration) delivered via ocular electrodes; type II isobolographic analysis was used to characterize the consequent anticonvulsant interactions between the drug combinations for fixed-ratios of 1:1, 1:2, 1:5 and 1:10. With type II isobolographic analysis, the combinations of levetiracetam with ethosuximide for the fixed-ratios of 1:5 and 1:10 were supra-additive (synergistic; P<0.05 and P<0.01, respectively) in terms of seizure suppression, while the combinations for the fixed-ratios of 1:1 and 1:2 were additive in the mouse 6 Hz psychomotor seizure model. The combinations of levetiracetam with ethosuximide for the fixed-ratios of 1:5 and 1:10 appear to be particularly favorable combinations exerting supra-additive interaction in the mouse 6 Hz psychomotor seizure model. Finally, it may be concluded that because of the synergistic interactions between levetiracetam and ethosuximide, the combination might be useful in clinical practice.
Źródło:: Journal of Pre-Clinical and Clinical Research; 2014, 08, 2
1898-2395
Pojawia się w:: Journal of Pre-Clinical and Clinical Research
Dostawca treści:: Biblioteka Nauki