Autor: Florek, J. - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: Alantolactone and isoalantolactone suppress maximal electroshock-induced tonic seizures in mice
Autorzy:: Luszczki, J.J.
Marzeda, E.
Kondrat-Wrobel, M.W.
Florek-Luszczki, M.
Powiązania:: https://bibliotekanauki.pl/articles/3044.pdf
Data publikacji:: 2014
Wydawca:: Instytut Medycyny Wsi
Tematy:: alantolactone
isoalantolactone
electroshock-induced tonic seizure
seizure
mice
mouse
treatment
Źródło:: Journal of Pre-Clinical and Clinical Research; 2014, 08, 1
1898-2395
Pojawia się w:: Journal of Pre-Clinical and Clinical Research
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 2.

Tytuł:: Interactions of levetiracetam with ethosuximide in the mouse 6 Hz psychomotor seizure model - a type II isobolographic analysis
Autorzy:: Luszczki, J.J.
Wlaz, A.
Kondrat-Wrobel, M.W.
Pyrka, D.
Florek-Luszczki, M.
Powiązania:: https://bibliotekanauki.pl/articles/3145.pdf
Data publikacji:: 2014
Wydawca:: Instytut Medycyny Wsi
Tematy:: 6 Hz psychomotor seizure model
antiepileptic drug
drug interaction
ethosuximide
levetiracetam
isobolographic analysis
Opis:: The aim of the present study was to characterize the anticonvulsant effects of levetiracetam in combination with ethosuximide in the mouse 6 Hz psychomotor seizure model. Limbic (psychomotor) seizure activity was evoked in albino Swiss mice by a current (32 mA, 6 Hz, 3 s stimulus duration) delivered via ocular electrodes; type II isobolographic analysis was used to characterize the consequent anticonvulsant interactions between the drug combinations for fixed-ratios of 1:1, 1:2, 1:5 and 1:10. With type II isobolographic analysis, the combinations of levetiracetam with ethosuximide for the fixed-ratios of 1:5 and 1:10 were supra-additive (synergistic; P<0.05 and P<0.01, respectively) in terms of seizure suppression, while the combinations for the fixed-ratios of 1:1 and 1:2 were additive in the mouse 6 Hz psychomotor seizure model. The combinations of levetiracetam with ethosuximide for the fixed-ratios of 1:5 and 1:10 appear to be particularly favorable combinations exerting supra-additive interaction in the mouse 6 Hz psychomotor seizure model. Finally, it may be concluded that because of the synergistic interactions between levetiracetam and ethosuximide, the combination might be useful in clinical practice.
Źródło:: Journal of Pre-Clinical and Clinical Research; 2014, 08, 2
1898-2395
Pojawia się w:: Journal of Pre-Clinical and Clinical Research
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 3.

Tytuł:: Effects of alizarin, betulin, curcumin, diosmin , linalool, menthofuran, α-terpineol, theobromine, β-thujaplicin and vanillin against maximal electroshock-induced seizures in mice
Autorzy:: Luszczki, J.J.
Wlodarczyk, M.
Glensk, M.
Marzeda, E.
Durmowicz, D.
Florek-Luszczki, M.
Powiązania:: https://bibliotekanauki.pl/articles/3040.pdf
Data publikacji:: 2013
Wydawca:: Instytut Medycyny Wsi
Źródło:: Journal of Pre-Clinical and Clinical Research; 2013, 07, 1
1898-2395
Pojawia się w:: Journal of Pre-Clinical and Clinical Research
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 4.

Tytuł:: Isobolographic characterization of interaction of levetiracetam with clobazam in the mouse 6 Hz psychomotor seizure model
Autorzy:: Luszczki, J.J.
Walz, A.
Marzeda, E.
Podgorska, D.
Durmowicz, D.
Florek-Luszczki, M.
Powiązania:: https://bibliotekanauki.pl/articles/3195.pdf
Data publikacji:: 2012
Wydawca:: Instytut Medycyny Wsi
Źródło:: Journal of Pre-Clinical and Clinical Research; 2012, 06, 1
1898-2395
Pojawia się w:: Journal of Pre-Clinical and Clinical Research
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 5.

Tytuł:: Effect of N-(p-ethoxycarbonylphenylmethyl) -p-isopropoxyphenylsuccinimide on the anticonvulsant action of four classical antiepileptic drugs in the mouse maximal electroshock-induced seizure model
Autorzy:: Łuszczki, J.J.
Marzeda, E.
Kondrat-Wrobel, M.W.
Wrobel, J.
Kocharov, S.L.
Florek-Luszczki, M.
Powiązania:: https://bibliotekanauki.pl/articles/3266.pdf
Data publikacji:: 2014
Wydawca:: Instytut Medycyny Wsi
Tematy:: N-(p-ethoxycarbonylphenylmethyl) -p-isopropoxyphenylsuccinimide
anticonvulsant action
antiepileptic drug
mice
mouse
electroshock-induced seizure model
seizure
Źródło:: Journal of Pre-Clinical and Clinical Research; 2014, 08, 1
1898-2395
Pojawia się w:: Journal of Pre-Clinical and Clinical Research
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 6.

Tytuł:: No effect of3-(N-p-isopropoxyphenylsuccinimidomethylamino)-cinnamic acid on anticonvulsant action of different classical antiepileptic drugs in mouse maximal electroshock-induced seizure model
Autorzy:: Luszczycki, J. J.
Marczewski, T.
Marzeda, E.
Durmowicz, D.
Podgorska, D.
Kocharov, S. L.
Florek-Luszczki, M.
Powiązania:: https://bibliotekanauki.pl/articles/972739.pdf
Data publikacji:: 2012
Wydawca:: Instytut Medycyny Wsi
Tematy:: antiepileptic drugs
maximal electroshock-induced seizures
pharmacokinetic/pharmacodynamic interaction
p-isopropoxyphenylsuccinimide derivative
Opis:: Introduction and objective: The aim of the study was to determine the effects of 3-(N-p-isopropoxyphenylsuccinimidomethylamino)-cinnamic acid (IPPSMA-CA – a new succinimide derivative) on the protective action of 4 classical antiepileptic drugs (AEDs): carbamazepine [CBZ], phenobarbital [PB], phenytoin [PHT] and valproate [VPA]), against maximal electroshock (MES)-induced tonic seizures in mice. Materials and methods: Tonic hind limb extension (seizure activity) was evoked in adult male albino Swiss mice by a current (sine-wave, 25 mA, 500 V, 50 Hz, 0.2 s stimulus duration) delivered via auricular electrodes. Acute adverse-effectprofiles of the combination of IPPSMA-CA and 4 classical AEDs (CBZ, PB, PHT and VPA) with respect to motor performance, long-term memory and skeletal muscular strength were measured in the chimney, passive avoidance and grip-strength tests, respectively. Results: IPPSMA-CA administered at 150 mg/kg (i.p.) significantly elevated the threshold for electroconvulsions in mice (p<0.01). IPPSMA-CA at doses of 50 and 100 mg/kg, however, had no significant impact on the threshold for electroconvulsions in mice. Nor did IPPSMA-CA (100 mg/kg) significantly affect the anticonvulsant activity of CBZ, PB, PHT and VPA in the MES test in mice. None of the examined combinations of IPPSMA-CA (100 mg/kg, i.p.) with CBZ, PB, PHT and VPA (at their ED50 values from the MES-induced seizure test) affected motor coordination in the chimney test, long-term memory in the passive avoidance task, and muscular strength in the grip-strength test in mice. This indicates no possible acute adverse effects in animals. Conclusions: IPPSMA-CA elevated the threshold for electroconvulsions in mice in a dose-dependent manner. However, IPPSMA-CA at a sub-protective dose of 100 mg/kg did not affect the anticonvulsant action of various classical AEDs in the mouse MES model. Thus, the combinations of IPPSMA-CA with CBZ, PB, PHT and VPA are neutral from a preclinical viewpoint.
Źródło:: Journal of Pre-Clinical and Clinical Research; 2012, 06, 1; 20-24
1898-2395
Pojawia się w:: Journal of Pre-Clinical and Clinical Research
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 7.

Tytuł:: Searching for in vitro biomarkers of susceptibility to prostate and cervical cancers by analysis of chromosomal instability, gamma-H2AX foci, polymorphisms in DNA repair genes and apoptosis
Autorzy:: Wegierek-Ciuk, A.
Arabski, M.
Kedzierawski, P.
Florek, A.
Solowiej, D.
Gozdz, S.
Lisowska, H.
Kowalik, A.
Kowalska, M.
Wojcik, A.
Polanska, J.
Lankoff, A.
Powiązania:: https://bibliotekanauki.pl/articles/3629.pdf
Data publikacji:: 2015
Wydawca:: Instytut Medycyny Wsi
Tematy:: in vitro biomarker
susceptibility
prostate
cervical cancer
cancer
patient
human disease
lymphocyte
man
ionizing radiation
chromosome instability
gamma-H2AX biomarker
polymorphism
DNA repair gene
apoptosis
Opis:: Introduction and objective. According to the cancer epidemiology databases, cancer is the second leading cause of death in developing countries. Moreover, the WHO predicts a continuing increase in the incidence of cancer, extending this trend well into the next several decades. Hence, it seems obvious that the prediction of cancer susceptibility and early diagnosis is an important goal for modern biomedical sciences. The aim of this study is to clarify the value of chromosomal damage, capacity for the repair of double-strand breaks (DSBs), polymorphisms in DNA repair genes, and apoptosis as prognostic markers for prostate and cervical cancer. Materials and methods. 30 prostate cancer patients and 30 cervical cancer patients were enrolled into the study. In addition, 30 healthy female donors and 30 healthy male donors served as controls. The following endpoints were investigated: frequency of micronuclei, gamma-H2AX fluorescence, XRCC1 194C>T, XRCC1 399G>A, XRCC3 IVS5–14 A>G, OGG1 326 Ser>Cys polymorphisms and apoptosis. Results. Among all tested factors, only the homozygous variant (Arg/Arg) in XRCC1 (399 Arg/Gln) was strongly associated with prostate cancer risk, and only a low apoptotic response was connected with cervical cancer risk. The presented study confirmed a positive association between the frequency of MN and increased prostate and cervical cancer risk. However, such a biomarker is not cancer specific. In addition, the information gained by analyzing the gamma-H2AX fluorescence, as well apoptosis, had no value for predicting the risk of prostate and cervical cancers. Conclusions. The final conclusion of the study is that cancer susceptibility is a complex phenotype not readily detectable in relatively small studies by functional assays or analysis of SNP in few, selected genes.
Źródło:: Journal of Pre-Clinical and Clinical Research; 2015, 09, 2
1898-2395
Pojawia się w:: Journal of Pre-Clinical and Clinical Research
Dostawca treści:: Biblioteka Nauki

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