Wszystkie pola: cancers - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: Epstein-Barr Virus - pathogenesis, latency and cancers
Autorzy:: Kliszczewska, Ewa
Jarzyński, Adrian
Boguszewska, Anastazja
Pasternak, Justyna
Polz-Dacewicz, Małgorzata
Powiązania:: https://bibliotekanauki.pl/articles/972458.pdf
Data publikacji:: 2017
Wydawca:: Instytut Medycyny Wsi
Tematy:: latency
infection
cancer
EBV
Opis:: The Epstein-Barr virus (EBV) was discovered in 1964 by Michael Anthony Epstein and Yvonne Barr, who discovered a herpesvirus-like infectious agent in a biopsy specimen from a patient with Burkitt’s lymphoma. This virus belongs to the Herpesviridae family (subfamily Gammaherpesvirinae, genus Lymphocryptovirus). EBV is a ubiquitous herpesvirus that is causally associated with various malignant tumours. According to the current nomenclature, it was named human herpesvirus type 4 (human herpesvirus 4 – HHV-4). Primary infection usually occurs in childhood. In developing countries, the infection rate among young children is higher than in developed countries. It was the first human tumour virus and it is currently categorized as a group-1 carcinogen due to its association with various cancers. It is estimated that over 90% of the adult population has been infected with this pathogen, but only a minority will develop the disease. EBV establishes latent infection characterized by the expression of a limited number of viral genes called latent genes. Moreover, during its life cycle, EBV periodically reactivates and can be transmitted to other susceptible hosts. The oral cavity is the main site of EBV occurrence and the most common source of infection. This study discusses EBV frequency and its association with the occurrence of malignant tumours and the pathways of tumour progression.
Źródło:: Journal of Pre-Clinical and Clinical Research; 2017, 11, 2; 142-146
1898-2395
Pojawia się w:: Journal of Pre-Clinical and Clinical Research
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 2.

Tytuł:: The role of microRNA (miRNA) as a biomarker in HPV and EBV-related cancers
Autorzy:: Kolesnik, M.
Stepien, E.
Polz-Dacewicz, M.
Powiązania:: https://bibliotekanauki.pl/articles/2098505.pdf
Data publikacji:: 2021
Wydawca:: Instytut Medycyny Wsi
Tematy:: biomarker
nucleotide sequence
cancer
cardiovascular disease
microRNA
Epstein-Barr virus
human papillomavirus
Opis:: Introduction and objective. Biomarkers are measurable biological indicators of many disease states. Particularly noteworthy are short nucleotide sequences involved in the regulation of many cellular processes. Their level in body fluids constitutes an important biological marker of serious diseases, such as cancer or cardiovascular diseases. For example, different types of microRNA may be used as biomarker in virus-associated cancers. The aim of this article was to review the current knowledge on the miRNAs and their role in viral-related cancers (EBV and HPV). The article reviews information available in journals and on electronic databases. Brief description of the state of knowledge. A significant part of the world’s population hosts at least one of the oncoviruses, but only a small percentage of them undergo a cancerogenesis to which these infectious agents contribute. Interaction between the host cell and viral factors can lead to the origination of a microenvironment favourable to oncogenesis. Cancer arises as a result of dysregulation in many cellular processes, and particularly important are short RNA sequences which regulate the processes that can cause this disease. The varied expression of this ribonucleic acid contributes to many diseases and provides valuable information about health. Importantly, these molecules are differentially expressed in virally-induced cancer. Many publications have confirmed the relationship between the expression of specific types of miRNA and cancers associated with EBV and HPV. Conclusions. The use of miRNAs as biomarkers of neoplastic diseases associated with EBV and HPV infections may significantly contribute to the reduction of mortality caused by these viruses, and thanks to the development of modern technologies they are an attractive research object.
Źródło:: Journal of Pre-Clinical and Clinical Research; 2021, 15, 2; 104-110
1898-2395
Pojawia się w:: Journal of Pre-Clinical and Clinical Research
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 3.

Tytuł:: Molecular and environmental aspects of skin cancers
Autorzy:: Zebracka, A.
Matysiak, M.
Dudra-Jastrzebska, M.
Kapka-Skrzypczak, L.
Powiązania:: https://bibliotekanauki.pl/articles/3509.pdf
Data publikacji:: 2015
Wydawca:: Instytut Medycyny Wsi
Tematy:: molecular aspect
environmental aspect
skin
cancer
malignant melanoma
basal cell carcinoma
squamous cell carcinoma
ultraviolet radiation
carcinogenesis
Opis:: Skin cancers are one of the most common cancers in the Caucasian population. A constantly increasing number of nonmelanoma skin cancers and malignant melanomas is observed. The incidence of skin cancers is associated mainly with exposure to sunlight. Therefore, agricultural workers who work in open spaces are a particularly vulnerable group. Currently, studies on the pathogenesis of skin cancer focus on the molecular basis associated with ultraviolet radiation. This study is an attempt to summarize the current state of knowledge on this issue. There have been demonstrated mutations in different classes of genes associated with carcinogenesis, including protooncogenes, tumour suppressor genes, genes that control apoptosis, genes encoding transcription factors and DNA repair genes in patients with skin cancers. Mutations in the latter result in reducing the effectiveness of DNA repair and fixation of mutations. All changes at the gene level lead to structural changes, quantitative and dysfunction of proteins encoded by these genes. All these factors contribute to the process of carcinogenesis. Due to increasing number of skin cancers, it seems important to increase knowledge of the molecular basis of skin cancers. This knowledge could be crucial for predicting the course of the disease, and for the development of new therapeutic strategies.
Źródło:: Journal of Pre-Clinical and Clinical Research; 2015, 09, 2
1898-2395
Pojawia się w:: Journal of Pre-Clinical and Clinical Research
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 4.

Tytuł:: Searching for in vitro biomarkers of susceptibility to prostate and cervical cancers by analysis of chromosomal instability, gamma-H2AX foci, polymorphisms in DNA repair genes and apoptosis
Autorzy:: Wegierek-Ciuk, A.
Arabski, M.
Kedzierawski, P.
Florek, A.
Solowiej, D.
Gozdz, S.
Lisowska, H.
Kowalik, A.
Kowalska, M.
Wojcik, A.
Polanska, J.
Lankoff, A.
Powiązania:: https://bibliotekanauki.pl/articles/3629.pdf
Data publikacji:: 2015
Wydawca:: Instytut Medycyny Wsi
Tematy:: in vitro biomarker
susceptibility
prostate
cervical cancer
cancer
patient
human disease
lymphocyte
man
ionizing radiation
chromosome instability
gamma-H2AX biomarker
polymorphism
DNA repair gene
apoptosis
Opis:: Introduction and objective. According to the cancer epidemiology databases, cancer is the second leading cause of death in developing countries. Moreover, the WHO predicts a continuing increase in the incidence of cancer, extending this trend well into the next several decades. Hence, it seems obvious that the prediction of cancer susceptibility and early diagnosis is an important goal for modern biomedical sciences. The aim of this study is to clarify the value of chromosomal damage, capacity for the repair of double-strand breaks (DSBs), polymorphisms in DNA repair genes, and apoptosis as prognostic markers for prostate and cervical cancer. Materials and methods. 30 prostate cancer patients and 30 cervical cancer patients were enrolled into the study. In addition, 30 healthy female donors and 30 healthy male donors served as controls. The following endpoints were investigated: frequency of micronuclei, gamma-H2AX fluorescence, XRCC1 194C>T, XRCC1 399G>A, XRCC3 IVS5–14 A>G, OGG1 326 Ser>Cys polymorphisms and apoptosis. Results. Among all tested factors, only the homozygous variant (Arg/Arg) in XRCC1 (399 Arg/Gln) was strongly associated with prostate cancer risk, and only a low apoptotic response was connected with cervical cancer risk. The presented study confirmed a positive association between the frequency of MN and increased prostate and cervical cancer risk. However, such a biomarker is not cancer specific. In addition, the information gained by analyzing the gamma-H2AX fluorescence, as well apoptosis, had no value for predicting the risk of prostate and cervical cancers. Conclusions. The final conclusion of the study is that cancer susceptibility is a complex phenotype not readily detectable in relatively small studies by functional assays or analysis of SNP in few, selected genes.
Źródło:: Journal of Pre-Clinical and Clinical Research; 2015, 09, 2
1898-2395
Pojawia się w:: Journal of Pre-Clinical and Clinical Research
Dostawca treści:: Biblioteka Nauki

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