- Tytuł:
- Correction by lisozyme of biochemical changes in periodontium of rats with Alloxane Diabetes
- Autorzy:
-
Levitsky, A.P.
Stupak, E.P. - Powiązania:
- https://bibliotekanauki.pl/articles/1032520.pdf
- Data publikacji:
- 2014
- Wydawca:
- Uniwersytet Kazimierza Wielkiego w Bydgoszczy
- Tematy:
-
alloxane diabetes
periodont
inflammation
dysbiosis
mineralization
lysozyme - Opis:
- Aim. Aim of this study is to investigate gingivitis development in rats with experimentally induced diabetes mellitus type 1 and study of therapeutic and prophylactic actions lysozyme on periodontal condition. Methods. Alloxane diabetes has been induced by single injection of alloxane, in dose 100 mg/kg. A gel with lysozyme in concentration 2 mg/ml inflicted on the gum everyday. Taking out the animals from experiment performed at 21-th day. In gomogenates of gums the biochemical markers were estimated: malone dyaldegyde, elastase, urease, lysozyme, catalase. In homogenates of alveolar bone the activity of phosphatases, proteolytic activity was determined. Results. With alloxane diabetes in gum increased levels of biochemical markers of inflammation and increases the degree of disbiosis. In alveolar bone increases the activity of acid phosphatase and dropping the index mineralization. Appliques on a gum gel with lysozyme fixes the phenomenon of dysbiosis and inflammation in the gum, restores the index of mineralization in the alveolar bone. Conclusion. In the pathogenesis of periodontal disorders in diabetes mellitus plays an important role developing of dysbiosis. For prevent the development it periodontal complication need the use of lysozyme gel.
- Źródło:
-
Journal of Health Sciences; 2014, 4, 1; 161-170
1429-9623 - Pojawia się w:
- Journal of Health Sciences
- Dostawca treści:
- Biblioteka Nauki
Artykuł