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Wyszukujesz frazę "Patel, A." wg kryterium: Autor


Wyświetlanie 1-2 z 2
Tytuł:
Determination of kinetic parameters of decomposition of tetrahydropyrimidine derivatives
Autorzy:
Bhesaniya, K.
Patel, A.
Baluja, S.
Powiązania:
https://bibliotekanauki.pl/articles/411745.pdf
Data publikacji:
2013
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
tetrahydropyrimidine derivative
TGA
DSC
kinetic parameter
Opis:
Some new tetrahydropyrimidine derivatives have been synthesized and their structural determination was done by IR, NMR and mass spectral data. Thermal analysis of these synthesized dihydropyrimidinthiones has been carried out by TGA and DSC techniques. From the thermograms, various kinetic parameters such as order of degradation (n), energy of activation (E), frequency factor (A) and entropy change (ΔS) have been evaluated. Further, thermal stability of tetrahydropyrimidine have been determined which is found to depend on the type of substituent present in the compounds.
Źródło:
International Letters of Chemistry, Physics and Astronomy; 2013, 13; 23-32
2299-3843
Pojawia się w:
International Letters of Chemistry, Physics and Astronomy
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Sustain release Formulation and Evaluation of Ofloxacin floating delivery system
Autorzy:
Patel, A. J.
Naik, D. R.
Raval, J. R.
Powiązania:
https://bibliotekanauki.pl/articles/412207.pdf
Data publikacji:
2014
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
ofloxacin
ethyl cellulose
xanthum gum
floating drug delivery System
controlled release
Opis:
Floating tablets has been accepted as a process to achieve controlled drug delivery by prolonging the residence time of the dosage form at the site of absorption, thereby improving and enhancing the bioavailability of drug. The objective of present study outlines the development and characterization the floating drug delivery system of Ofloxacin to enhance its bioavailability and therapeutic efficacy, using different grades of polymer along with effervescent agent sodium bicarbonate and citric acid. Ofloxacin is a synthetic chemotherapeutic second-generation antibiotic of the fluoroquinolone class. Different tablet formulations were formulated by wet granulation technique and were evaluated for physical parameters like Tablet Thickness, Hardness, % Friability, Weight variation, Content uniformity, In vitro buoyancy, Swelling index, In vitro dissolution study and drug release mechanisms. As the concentration of the polymer in the formulations increased the release of drug decreased. Hence it was considered as suitable candidate for formulation as floating drug delivery system. Different kinetic models were applied to drug release data in order to evaluate release mechanisms and kinetics. The optimized formula F4 showed better sustained drug release with good floating properties and fitted best to be Korsmeyer-Peppas model with R2 value of 0.9575. As the n value for the Korsmeyer- Peppas model was found be more than 0.5 it follows Non-Fickian diffusion mechanism. FTIR result showed that there is no drug excipients interaction.
Źródło:
International Letters of Chemistry, Physics and Astronomy; 2014, 12; 69-83
2299-3843
Pojawia się w:
International Letters of Chemistry, Physics and Astronomy
Dostawca treści:
Biblioteka Nauki
Artykuł
    Wyświetlanie 1-2 z 2

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