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    Wyświetlanie 1-6 z 6
    Tytuł:
    Toxicity of Some Phenolic Derivatives : In Vitro Studies
    Autorzy:
    Zapór, L.
    Powiązania:
    https://bibliotekanauki.pl/articles/89791.pdf
    Data publikacji:
    2004
    Wydawca:
    Centralny Instytut Ochrony Pracy
    Tematy:
    phenol
    catechol
    resorcinol
    hydroquinone
    phloroglucinol
    cytotoxicity
    fenol
    hydrochinon
    badania in vitro
    działanie toksyczne
    substancje toksyczne
    rezorcynol
    zagrożenia chemiczne
    Opis:
    Cytotoxicity of 5 phenol derivatives (phenol, catechol, resorcinol, hydroquinone and phloroglucinol) wastested using a mouse 3T3 fibroblast cell line. Its relationships with structural and physicochemical properties were investigated. Linear regression analysis and Pearson’s correlation coefficient were used to characterise the relationship between cytotoxicity (expressed by IC50 values) and physicochemical parameters of compounds or their toxicity in vivo expressed by LD50 values. The studies showed that physicochemical properties of compounds seemed to have less influence on their cytotoxic potency than structural properties. Cytotoxicity of the compounds probably depends on the number of -OH groups and their location in the aromatic ring more than on physicochemical properties of compounds. The best correlation was obtained for IC50 values and LD50 values determined following rabbit skin administration and experimental skin irritation score.
    Źródło:
    International Journal of Occupational Safety and Ergonomics; 2004, 10, 4; 319-331
    1080-3548
    Pojawia się w:
    International Journal of Occupational Safety and Ergonomics
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Evaluation of the Toxic Potency of Selected Cadmium Compounds on A549 and CHO-9 Cells
    Autorzy:
    Zapór, L.
    Powiązania:
    https://bibliotekanauki.pl/articles/90271.pdf
    Data publikacji:
    2014
    Wydawca:
    Centralny Instytut Ochrony Pracy
    Tematy:
    cadmium sulphide
    cadmium chloride
    cadmium oxide
    siarczek kadmu
    chlorek kadmu
    tlenek kadmu
    Opis:
    Cytotoxicity of cadmium sulphide, oxide and chloride was tested using A549 and CHO-9 cells. Metabolic activity of cells (MTT test) and cell membrane permeability (NRU test) were used as cytotoxicity endpoints. The results revealed unexpectedly low toxicity of cadmium sulphide as compared to chloride and oxide. This preliminary report does not provide any explanation for this effect, but the result may nevertheless be interesting for future studies of toxicity mechanisms of cadmium compounds. First cadmium compounds caused damage or change in the permeability of cell membranes, then inhibition of metabolic activity of mitochondria. It cannot be ruled out that the cell lysosomes are at first exposed to the effect of cadmium.
    Źródło:
    International Journal of Occupational Safety and Ergonomics; 2014, 20, 4; 573-581
    1080-3548
    Pojawia się w:
    International Journal of Occupational Safety and Ergonomics
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Cytotoxicity of Resorcinol Under Short- and Long-Term Exposure in Vitro
    Autorzy:
    Skowroń, J.
    Zapór, L.
    Powiązania:
    https://bibliotekanauki.pl/articles/90515.pdf
    Data publikacji:
    2004
    Wydawca:
    Centralny Instytut Ochrony Pracy
    Tematy:
    resorcinol
    short-term toxicity
    long-term toxicity
    bioreactor
    in vitro methods
    rezorcynol
    toksyczność chroniczna
    działanie toksyczne
    substancje toksyczne
    substancje niebezpieczne
    ekspozycja długotrwała
    ekspozycja chwilowa
    zatrucia
    Opis:
    Cytotoxicity of resorcinol to 3T3 fibroblast in short- (3 hrs) and long-term (72 hrs or 6 weeks) exposure was investigated. The effects of resorcinol on cell viability (neutral red uptake, NRU assay), mitochondrial function (MTT assay) and total cell protein (Kenacid Blue assay) were estimated. As a model for long-term exposure an INTEGRA CL 6-WELL bioreactor was used. The concentrations of resorcinol producing 20, 50 and 80% inhibition of cell growth in the NRU test were lower than in the MTT test after 3 hrs of exposure. The use of an INTEGRA CL 6-WELL bioreactor allows continuous culturing and exposure to test chemical of cells for several weeks, but the strong adhesiveness of fibroblast and forming aggregates make it difficult to remove them from chambers. Resorcinol in concentration of 1 μ/cm³ did not decrease the viability of cells to 50% of control in long-term exposure in the bioreactor.
    Źródło:
    International Journal of Occupational Safety and Ergonomics; 2004, 10, 2; 147-156
    1080-3548
    Pojawia się w:
    International Journal of Occupational Safety and Ergonomics
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The Cytotoxicity of Some Organic Solvents on Isolated Hepatocytes in Monolayer Culture
    Autorzy:
    Zapór, L.
    Skowroń, J.
    Gołofit-Szymczak, M.
    Powiązania:
    https://bibliotekanauki.pl/articles/91193.pdf
    Data publikacji:
    2002
    Wydawca:
    Centralny Instytut Ochrony Pracy
    Tematy:
    in vitro methods
    hepatocytes in monolayer culture
    organic solvents
    MTT assay
    kwasy organiczne
    toksykologia
    metoda in vitro
    cytotoksyczność
    hepatocyty
    Opis:
    The cytotoxic effects of volatile and water-insoluble organic solvents (ethylbenzene, tetrachloroethylene, n-hexane) were tested on isolated hepatocytes in monolayer culture by using the 3-(4,5 dimethylthiazol-2-yl)-2,5 diphenyltetrazolium bromide (MTT) reduction assay. All of the tested compounds inhibited metabolic activity of hepatocytes and this effect depended on the concentration of solvents in the incubatory medium. The presence of fetal calf serum in the medium did not change the cytotoxicity of xenobiotics. IC50 values calculated on the basis of the MTT assay indicated that ethylbenzene was more cytotoxic than tetrachloroethylene and n-hexane. Using hepatocyte monolayer culture and the MTT assay to assess cytotoxicity of organic solvents causes many technical problems. It seems that it cannot be used as a rapid, cheap, and credible method.
    Źródło:
    International Journal of Occupational Safety and Ergonomics; 2002, 8, 1; 121-129
    1080-3548
    Pojawia się w:
    International Journal of Occupational Safety and Ergonomics
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Classification of the Substances on the Basis of the Acute-Toxic-Class Method (ATC)
    Autorzy:
    Skowroń, J.
    Zapór, L.
    Miranowicz-Dzierżawska, K.
    Powiązania:
    https://bibliotekanauki.pl/articles/90309.pdf
    Data publikacji:
    1998
    Wydawca:
    Centralny Instytut Ochrony Pracy
    Tematy:
    acute-toxic-class method
    alternative LD50 test
    animal welfare
    classification
    toksyczność
    substancje chemiczne
    zwierzęta
    Opis:
    The acute-toxic-class method (ATC) is an alternative to the classical LD50 test. Four substances were tested with an ATC testing procedure. The results were compared with LD50 data obtained from the literature. Great importance was attached to the observations of toxic signs following administration. The results of this study have shown that the ATC method allows allocation to toxicity classes in the same manner as on the basis of the classical LD50 tests. The ATC method uses fewer animals and yields the same information on toxic signs. Introducing the ATC method into the quality system allows estimating the acute oral toxicity of chemicals according to the Organisation for Economic Cooperation and Development (OECD; OECD, 1992, 1996).
    Źródło:
    International Journal of Occupational Safety and Ergonomics; 1998, 4, 1; 107-115
    1080-3548
    Pojawia się w:
    International Journal of Occupational Safety and Ergonomics
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Interactions of Some Organic Solvents: Hydrocarbons and Chloroalkene
    Autorzy:
    Skowroń, J.
    Miranowicz-Dzierżawska, K.
    Zapór, L.
    Gołofit-Szymczak, M.
    Starek, A.
    Powiązania:
    https://bibliotekanauki.pl/articles/90439.pdf
    Data publikacji:
    2001
    Wydawca:
    Centralny Instytut Ochrony Pracy
    Tematy:
    n-hexane
    ethylbenzene
    tetrachloroethylene
    metabolic interactions
    toxicodynamic interactions
    interakcje metaboliczne
    tetrachloroetylen
    etylobenzen
    Opis:
    Metabolic and toxicodynamic interactions of some organic solvents in rats repeatedly treated with medium dose levels were examined. It was shown that both n-hexane and ethylbenzene significantly inhibited tetrachloroethylene metabolism during a 2-week period. n-Hexane and tetrachloroethylene enhanced metabolism of ethylbenzene whereas ethylbenzene suppressed n-hexane metabolism only at the end of the experiment. Biochemical changes, especially the drop in the level of non-protein sulfhydryl groups in tissues of rats treated with organic solvent mixtures, were significantly less pronounced than those observed after these chemicals were administered separately. These results demonstrate that metabolic interactions between hydrocarbons and chloroalkene may lead to a modification of the biological response to these compounds.
    Źródło:
    International Journal of Occupational Safety and Ergonomics; 2001, 7, 1; 35-47
    1080-3548
    Pojawia się w:
    International Journal of Occupational Safety and Ergonomics
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-6 z 6

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