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    Wyświetlanie 1-5 z 5
    Tytuł:
    Epidemiology of silicosis reported to the central register of occupational diseases over last 20 years in Poland
    Autorzy:
    Nowak-Pasternak, Joanna
    Lipińska-Ojrzanowska, Agnieszka
    Świątkowska, Beata
    Powiązania:
    https://bibliotekanauki.pl/articles/2152952.pdf
    Data publikacji:
    2022
    Wydawca:
    Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
    Tematy:
    Polska
    occupational diseases
    epidemiology
    silica
    silicosis
    pneumoconioses
    Opis:
    Objectives The aim of the study was to investigate and assess the incidence of silicosis cases acknowledged as occupational diseases in Poland in 2000–2019. Material and Methods The cases of all medically recognized pneumoconioses, including silicoses, certified as occupational diseases were studied. The records were extracted from the Central Register of Occupational Diseases, the only official Polish central electronic data base of occupational diseases. Results During the period 2000–2019, 2066 confirmed cases of silicoses and 10 665 cases of other pneumoconioses including asbestosis and coal workers’ pneumoconiosis were reported to the Central Register of Occupational Diseases. Silicoses accounted for 12.8–21.2% of all pneumoconioses. The number of confirmed silicoses cases was growing along with the length of latency period and was the highest for the period of ≥40 years (513 cases). Over 70% of silicoses cases occurred after occupational exposure >20 years. The most workers who evolved silicosis were employed in manufacturing, predominantly casting of iron, mining and quarrying and construction. Conclusions The number of confirmed cases of silicosis in Poland decreased in 2000–2019 but the disease still remains an important health problem. Prevention is crucial to reduce further disease incidence. The medical monitoring standards of exposed workers should be improved. Developing new diagnosing guidelines with the use of other imaging examinations, like high-resolution computed tomography, has to be considered. The analysis should contribute into the implementation of silicosis preventative programmes, both at the enterprise and national level.
    Źródło:
    International Journal of Occupational Medicine and Environmental Health; 2022, 35, 5; 561-570
    1232-1087
    1896-494X
    Pojawia się w:
    International Journal of Occupational Medicine and Environmental Health
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Pneumomediastinum, bilateral pneumothorax and subcutaneous emphysema complicating acute silicosis
    Autorzy:
    Dixit, Ramakant
    Meena, Manoj
    Patil, Chetan B.
    Powiązania:
    https://bibliotekanauki.pl/articles/2177340.pdf
    Data publikacji:
    2015-04-15
    Wydawca:
    Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
    Tematy:
    silicosis
    Pneumothorax
    pneumomediastinum
    subcutaneous emphysema
    stone factories
    Opis:
    A case of acute silicosis complicating as spontaneous pneumomediastinum, bilateral pneumothorax and subcutaneous emphysema is described in a 35-year-old male engaged in stone crusher unit. Diagnosis was established on clinical and radiological assessment and supported by occupational history of the patient. This case is unique one as all these 3 complications at the same time are very uncommon in acute silicosis.
    Źródło:
    International Journal of Occupational Medicine and Environmental Health; 2015, 28, 3; 635-638
    1232-1087
    1896-494X
    Pojawia się w:
    International Journal of Occupational Medicine and Environmental Health
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Evaluation of differential serum expression of three factors and pulmonary function in patients with silicosis
    Autorzy:
    Zhu, Ying
    Duan, Xia Yu
    Cheng, Yun Qi
    Yao, Xin Jing
    Xu, Hong
    Zhang, Kui Sheng
    Li, Feng Shi
    Yang, Fang
    Liu, Liang He
    Yuan, Xiang Ju
    Powiązania:
    https://bibliotekanauki.pl/articles/2086531.pdf
    Data publikacji:
    2021-08-05
    Wydawca:
    Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
    Tematy:
    silicosis
    pulmonary function
    early diagnosis
    ROC
    PTPN2
    factor B
    Opis:
    ObjectivesSilicosis is a chronic occupational lung disease. As was previously found by the authors, some proteins increased in the lung tissue of activated rats, and protein tyrosine phosphatase non-receptor type 2 (PTPN2), factor B, and vaccinia-related kinase 1 (VRK1) showed highly differential expressions.Material and MethodsIn this study, serum and bronchoalveolar lavage fluid samples were collected from patients with silicosis and healthy people to verify the expression of PTPN2, factor B, and VRK1. The diagnostic value of differentially expressed proteins for silicosis was judged.ResultsThe expression levels of serum PTPN2, VRK1, and factor B in patients with silicosis were significantly higher than those in the control group (p < 0.01). Higher serum PTPN2 and factor B concentrations significantly and negatively correlated with the ratio of forced expiratory volume in 1 s to forced vital capacity (FEV1/FVC), maximum vital capacity (VCmax), FEV1, and FVC, suggesting that the high expression of PTPN2 and factor B is associated with decreased pulmonary ventilation function and restrictive ventilatory impairment in patients with silicosis. All area under curve (AUC) measurements generated from single detection events were >0.744, with PTPN2 reaching the highest value (0.858). The AUC, sensitivity, and specificity for the combined diagnosis using factor B and PTPN2 were 0.907, 86.91% and 85.07%, respectively, for factor B and PTPN2. The 3 differentially expressed proteins are potential classes of predictive biomarkers for silicosis.ConclusionsRegarding the economy and test practicality, the best diagnostic combination is factor B and PTPN2 for the analysis of AUC, sensitivity and specificity.
    Źródło:
    International Journal of Occupational Medicine and Environmental Health; 2021, 34, 4; 527-540
    1232-1087
    1896-494X
    Pojawia się w:
    International Journal of Occupational Medicine and Environmental Health
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Silicosis in Switzerland
    Autorzy:
    Koller, Michael F.
    Scholz, Stefan M.
    Pletscher, Claudia
    Miedinger, David
    Powiązania:
    https://bibliotekanauki.pl/articles/2162017.pdf
    Data publikacji:
    2018-10-23
    Wydawca:
    Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
    Tematy:
    lung cancer
    silicosis
    quartz
    occupational exposure limit
    crystalline silica
    Switzerland
    Opis:
    Objectives The correlation between quartz dust concentrations in the Swiss enterprises and the incidence of silicosis and other related diseases acknowledged as occupational diseases (OD) was investigated. Material and Methods Quartz dust concentrations were obtained from Suva’s databases of occupational health surveillance measurements between 2005 and 2014. Information on quartz dust-related diseases was from medical dossiers of workers with OD acknowledged by Suva between 2005 and 2014. Results The median quartz dust concentration of the 2579 measurements between 2005 and 2014 was 0.09 mg/m³ (alveolar fraction). Out of all measurements, 28% were above the Swiss occupational exposure limit (OEL) of 0.15 mg/m³ (alveolar fraction). One hundred eighty-one individuals suffered from acknowledged quartz dust-related disease (179 silicosis and 2 chronic obstructive pulmonary disease (COPD)). Additionally, 8 out of these workers were diagnosed with lung cancer and 55 with COPD of a non-specified cause. Out of all workers, 46% were exposed to silica dust for the first time before 1975 when the current Swiss OEL was introduced. Out of the foreign workers, 63% began to work abroad, during which they could have at least partly acquired their silicosis. Out of all workers, 75% were ever-smokers. Conclusions The incidence of silicosis decreased drastically from approximately 300 cases/year in the 1970s to fewer than 20 cases/year 20 years ago. Several findings of this study that could help to interpret the ongoing occurrence of the disease include excessive exposure in or outside of Switzerland in former or current times, vulnerability to the development of silicosis due to cigarette smoke, or poor compliance with wearing breathing masks. Int J Occup Med Environ Health 2018;31(5):659–676
    Źródło:
    International Journal of Occupational Medicine and Environmental Health; 2018, 31, 5; 659-676
    1232-1087
    1896-494X
    Pojawia się w:
    International Journal of Occupational Medicine and Environmental Health
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Subcutaneous administration of infliximab-attenuated silica-induced lung fibrosis
    Autorzy:
    Zhang, Hua
    Sui, Jun-Na
    Gao, Lei
    Guo, Jian
    Powiązania:
    https://bibliotekanauki.pl/articles/2162006.pdf
    Data publikacji:
    2018-07-04
    Wydawca:
    Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
    Tematy:
    infliximab
    silicosis
    TNF-α
    rat model
    NF-κB
    iNOS
    Opis:
    Objectives To investigate the influence of the anti-tumor necrosis factor-α infliximab (IFX) in the case of rats with silicosis. Material and Methods Forty-eight Wistar rats were randomly divided into 3 groups. The study group (N = 16) – silicosis was induced by intratracheal instillation of 50 mg silica on day 1, and IFX was subcutaneously administered at a dose of 15 mg/kg of body weight from day 2 to day 6, the vehicle group (N = 16) – silica used as the study group but without IFX, the sham group (N = 16) – 1 ml of saline was intratracheal-used. Eight rats in each group were euthanized on day 7 and on day 14, respectively. Lung tissue sections were stained with hematoxylin and eosin or Masson’s trichromedye. The nuclear factor-κB p65 (NF-κB p65) positioning in the lung tissues were determined by immunohistochemical staining. Levels of tumor necrosis factor α (TNF-α) in rat serum and bronchoalveolar lavage fluid were measured with enzyme linked immunosorbent assay. The inducible nitric oxide synthase (iNOS) mRNA in the lung tissues was measured by quantitative real-time polymerase chain reaction, as well as inhibitor protein-κB (I-κB) and NF-κB p65 expression were measured quantitatively by western blotting. Results Silica installation increased the lung tissues inflammation reaction, oxidative stress and pulmonary fibrosis. Infliximab treatment significantly improved silica-induced lung pathological changes (inflammatory cells, collagen deposition), decreased the TNF-α inhibited NF-κB signaling (I-κB, NF-κB p65) as well as oxidant status (iNOS). Conclusions Infliximab may improve silica-induced pulmonary inflammation by decreasing the TNF-α, inhibiting NF-κB signaling (I-κB, NF-κB p65) as well as oxidant status (iNOS), which suggest that IFX has potential role in the treatment of silica-induced lung damage. Int J Occup Med Environ Health 2018;31(4):503–515
    Źródło:
    International Journal of Occupational Medicine and Environmental Health; 2018, 31, 4; 503-515
    1232-1087
    1896-494X
    Pojawia się w:
    International Journal of Occupational Medicine and Environmental Health
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-5 z 5

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