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    Wyświetlanie 1-6 z 6
    Tytuł:
    Blood lead determinants and the prevalence of neuropsychiatric symptoms in firearm users in Mexico
    Autorzy:
    Aguilar Madrid, Guadalupe
    Téllez-Cárdenas, Liliana
    Juárez-Pérez, Cuauhtémoc A.
    Haro-García, Luis C.
    Mercado-García, Adriana
    Gopar-Nieto, Rodrigo
    Cabello-López, Alejandro
    Powiązania:
    https://bibliotekanauki.pl/articles/2177065.pdf
    Data publikacji:
    2015-11-12
    Wydawca:
    Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
    Tematy:
    neuropsychiatric symptoms
    occupational exposure
    lead exposure
    blood lead
    firearms
    heavy metal toxicity
    Opis:
    Objectives To identify blood lead predictors and the prevalence of neuropsychiatric symptoms in firearm users of public security in Mexico. Material and Methods A cross-sectional study was performed on 65 males. We obtained socio-occupational data and determined venous blood lead (blood (B), lead (Pb) – BPb), as well as neuropsychiatric symptoms using the Q-16 questionnaire. A multiple linear regression model was constructed to assess determinants of BPb. Results The mean age in the study group was 34.8 years (standard deviation (SD) = 6.9, range: 21–60); the mean number of years spent in the company amounted to 14 years (SD = 8.5, range: 1–48). Twenty percent of the respondents (N = 13) used leaded glazed clay pottery (lead (Pb), glazed (G), and clay pottery (C) – PbGC) in the kitchen. During practice they fired a mean of 72 shots (SD = 60, range: 20–250), and during their whole duration of employment 5483 shots (SD = 8322.5, range: 200–50 000). The mean BPb was 7.6 μg/dl (SD = 6.8, range: 2.7–51.7). Two caretakers from the firing range had 29.6 μg/dl and 51.7 μg/dl BPb. The subjects who had shooting practice sessions ≥ 12 times a year reported a greater percentage of miscarriages in their partners (24% vs. 0%). Twelve percent of the respondents showed an increase in neuropsychiatric symptoms. The BPb multiple linear regression model explained R² = 44.15%, as follows: those who had ≥ 12 practice sessions per year – β = 0.5339 and those who used PbGC – β = 0.3651. Conclusions Using firearms and PbGC contributes to the increased BPb in the studied personnel. The determinants of BPb were: shooting practices >12 times a year and using PbGC. Blood lead concentrations reported in the study, despite being low, are a health risk, as evidenced by the prevalence of neuropsychiatric symptoms.
    Źródło:
    International Journal of Occupational Medicine and Environmental Health; 2016, 29, 2; 219-228
    1232-1087
    1896-494X
    Pojawia się w:
    International Journal of Occupational Medicine and Environmental Health
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The role of probiotic intervention in regulating gut microbiota, short-chain fatty acids and depression-like behavior in lead-exposed rats
    Autorzy:
    Chen, Xiaojun
    Meng, Shujuan
    Yu, Yongli
    Li, Shuang
    Wu, Lei
    Zhang, Yanshu
    Powiązania:
    https://bibliotekanauki.pl/articles/2085714.pdf
    Data publikacji:
    2022-02-15
    Wydawca:
    Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
    Tematy:
    depression
    lead exposure
    probiotic
    gut microbiota
    SCFAs
    neurobehavioral tests
    Opis:
    ObjectivesThe aim of this study was to observe the depression-like behavior changes of rats exposed to lead with or without probiotic intervention, and to investigate changes in the gut microbiota and fecal short-chain fatty acids (SCFAs) levels after lead exposure, and the possible functions of probiotics in this process.Material and MethodsAdult male Sprague Dawley rats were exposed to a 300 mg/l lead acetate solution for 24 weeks, with or without probiotic (freeze-dried powder containing Lactobacillus and Bifidobacterium: 6 billion live bacteria/2 g) intervention in weeks 17–24. The sucrose preference test (SPT), the forced swim test (FST), and the tail suspension test (TST) were preformed to study the depression-like behaviors of these rats. The alteration of rat gut microbiota induced by lead exposure was analyzed by 16S rRNA sequencing, and the levels of fecal SCFAs were detected using gas chromatography.ResultsNeurobehavioral tests showed that lead exposure induced depression-like behavior in rats, including reduced sucrose preference in the SPT, and increased immobility times in the FST and the TST. Sequencing and gas chromatography showed that lead exposure changed the structure and the phylogenetic diversity of the gut microbiota, as well as significantly altered the levels of SCFAs. Moreover, the depression-like behaviors, and the changes in both gut microbiota and SCFAs, could be mitigated by probiotic intervention.ConclusionsLead exposure not only changes the structure and diversity of the gut microbiome but also affects metabolic function. Probiotic intervention may be a novel initiative for the prevention and treatment of neurological damage following lead exposure. Health. 2022;35(1):95–106
    Źródło:
    International Journal of Occupational Medicine and Environmental Health; 2022, 35, 1; 95-106
    1232-1087
    1896-494X
    Pojawia się w:
    International Journal of Occupational Medicine and Environmental Health
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Low-level environmental lead exposure and intellectual impairment in children — The current concepts of risk assessment
    Autorzy:
    Jakubowski, Marek
    Powiązania:
    https://bibliotekanauki.pl/articles/2185480.pdf
    Data publikacji:
    2011-03-01
    Wydawca:
    Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
    Tematy:
    lead
    children
    risk assessment
    environmental exposure
    Opis:
    Lead is an environmental contaminant. The majority of epidemiological research on the health effects of lead has been focused on children, because they are more vulnerable to lead than adults. In children, an elevated blood lead (B-Pb) is associated with reduced Intelligence Quotient (IQ) score. This paper summarizes the current opinions on the assessment of the health risk connected with the children’s environmental exposure to lead. The B-Pb level of concern of 100 μg/l proposed by the US Centers of Disease Control in 1991 was for a long time accepted as the guideline value. In the meantime there has been a significant worldwide decrease of B-Pb levels in children and present geometric mean values in the European countries range from 20 to 30 μg/l. The recent analyses of the association of intelligence test scores and B-Pb levels have revealed that the steepest declines in IQ occur at blood levels < 100 μg/l and that no threshold below which lead does not cause neurodevelopmental toxicity can be defended. European Food Safety Authority (EFSA) concluded in 2010, on the basis of results of Benchmark Dose (BMD) analysis, that an increase in B-Pb of 12 μg/l (BMDL₀₁) could decrease the IQ score by one point. It seems that this value can be used as a “unit risk” to calculate the possible decrease of IQ and, consequently, influence of the low-level exposure to lead (< 100 μg/l) on the health and socioeconomic status of the exposed population.
    Źródło:
    International Journal of Occupational Medicine and Environmental Health; 2011, 24, 1; 1-7
    1232-1087
    1896-494X
    Pojawia się w:
    International Journal of Occupational Medicine and Environmental Health
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The determinants of lead and cadmium blood levels for preschool children from industrially contaminated sites in Poland
    Autorzy:
    Kowalska, Małgorzata
    Kulka, Elżbieta
    Jarosz, Wanda
    Kowalski, Michał
    Powiązania:
    https://bibliotekanauki.pl/articles/2159917.pdf
    Data publikacji:
    2017-12-21
    Wydawca:
    Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
    Tematy:
    exposure
    cadmium
    lead
    preschool children
    ICS
    parental questionnaire
    Opis:
    Objectives Industrially contaminated sites (ICS) represent an important public health issue in European countries. The Silesian Voivodeship, the region located in the southern part of Poland, the historical center of industry, has many sites that meet ICS criteria. Most of them are landfills containing lead, cadmium and zinc. Material and Methods The aim of the study has been to evaluate determinants of lead and cadmium blood levels for preschool children living in the vicinity of selected environmental hazards in Piekary Śląskie, the city located in the region of Silesia. Data about exposure was obtained from the parental questionnaire and was verified by levels of biomarkers in children’s blood. Finally, 678 preschool children were studied. Results Obtained results have confirmed that the statistically significant higher level of lead in blood has been revealed in the case of younger children whose fathers have a higher level of education and whose mothers smoke cigarettes at home, as well as for those living in the vicinity of any environmental hazard. In the case of cadmium, a higher level of the biomarker has been reported for older children who rather do not live close to any environmental hazard. We have recognized 30% of children with blood lead level (PbB) exceeding 2 μg/dl and 0.8% of children with blood cadmium level (CdB) exceeding the reference value (0.5 μg/l). Conclusions Own observation has confirmed that preschool children living in Piekary Śląskie are still exposed to heavy metals existing in environment. The source of the higher level in blood is not only the hazardous vicinity in the place of residence but also well-known factors associated with the age of children, parental life style and educational background. The parental questionnaire could be useful to identify potential determinants of exposure to lead and cadmium, however exposure must be verified by measurement of a proper biomarker. Int J Occup Med Environ Health 2018;31(3):351–359
    Źródło:
    International Journal of Occupational Medicine and Environmental Health; 2018, 31, 3; 351-359
    1232-1087
    1896-494X
    Pojawia się w:
    International Journal of Occupational Medicine and Environmental Health
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Association between occupational lead exposure and plasma levels of selected oxidative stress related parameters in Jordanian automobile workers
    Autorzy:
    Shraideh, Ziad
    Badran, Darwish
    Hunaiti, Abdelrahim
    Battah, Abdelkader
    Powiązania:
    https://bibliotekanauki.pl/articles/2160039.pdf
    Data publikacji:
    2018-07-04
    Wydawca:
    Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
    Tematy:
    cytotoxicity
    biomarkers
    Oxidative stress
    exposure
    lead
    occupational health
    Opis:
    Objectives: To study any possible correlation between blood lead levels and some oxidative stress parameters of selected groups of lead-exposed automobile occupational Jordanian workers. Material and Methods: Blood lead levels were determined for a total of 90 male automobile workers aged within the range of 25–45 years old along with the group of 20 agematched healthy males control. To get an idea about the antioxidant status of controls and lead-exposed workers, and to estimate the oxidative stress caused by exposure to lead, we measured the hydrogen peroxide (H2O2) concentration, superoxide dismutase (SOD) activity, lipid peroxidation as malondialdehyde (MDA) and total antioxidant capacity of controls and workers. Results: The study showed that lead levels in the case of workers were approximately 4–5 times as high as in controls 14.5–21 μg×dl–1 vs. 4.3 μg×dl–1, respectively. There was a significant decrease (16–25%) in the level of plasma reduced glutathione and 21–33% decrease in total antioxidant capacity (TAOC) in all worker groups, as compared to controls. The results showed that the concentration of malondialdehyde (MDA) in plasma was higher (120–333%) in the case of workers than controls being the highest in automobile electronics and the lowest – in mechanics. Furthermore, there was 149–221% increase in hydrogen peroxide (H2O2) concentration, and 26–38% increase in SOD activity in the case of workers compared to the control group. Conclusions: There is a strong evidence for the associations between occupational lead exposure and various markers of oxidative stress in Jordanian automobile occupational workers. Thus, there is an urgent need to raise awareness and to initiate suitable protection guidelines for workers. Int J Occup Med Environ Health 2018;31(4):517–525
    Źródło:
    International Journal of Occupational Medicine and Environmental Health; 2018, 31, 4; 517-525
    1232-1087
    1896-494X
    Pojawia się w:
    International Journal of Occupational Medicine and Environmental Health
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Usefulness of biomarkers as intermediate endpoints in health risks posed by occupational lead exposure
    Autorzy:
    Borghini, Andrea
    Gianicolo, Emilio Antonio
    Andreassi, Maria Grazia
    Powiązania:
    https://bibliotekanauki.pl/articles/2177066.pdf
    Data publikacji:
    2015-10-16
    Wydawca:
    Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
    Tematy:
    biomarkers
    occupational exposure
    lead
    individual susceptibility
    genotoxic effects
    health risk
    Opis:
    The article concerns potential harmful effects of exposure to lead. Although the occurrence of severe lead poisoning has receded in several countries, occupational exposure resulting in moderate and clinically symptomatic toxicity is still common. An earlier and precise characterization of an individual response is obligatory in order to assess the possible risks for human health. Biomarkers may fill important gaps in the path from exposure to a disease. Specifically speaking, emerging (DNA double strand breaks and telomeric DNA erosion) and validated (micronuclei induction and chromosomal aberrations) biomarkers of genotoxicity seem to provide evidence for the assessment of molecular and cellular damage. Moreover, identification of genetic variability with a key role in modulating genotoxic damage may help minimize risks for susceptible subjects. Further investigations are naturally needed to properly define their diagnostic and/or prognostic value as “early warning” signs of a long-term risk for a subsequent clinically overt disease.
    Źródło:
    International Journal of Occupational Medicine and Environmental Health; 2016, 29, 2; 167-178
    1232-1087
    1896-494X
    Pojawia się w:
    International Journal of Occupational Medicine and Environmental Health
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-6 z 6

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