- Tytuł:
- Risk factors of acute respiratory distress syndrome after on-pump cardiac surgery in the INFLACOR cohort study
- Autorzy:
-
Kowalik, Maciej Michał
Lango, Romuald
Łoś, Andrzej
Chmara, Magdalena
Brzeziński, Maciej
Lewandowski, Krzysztof
Klapkowski, Andrzej
Rogowski, Jan - Powiązania:
- https://bibliotekanauki.pl/articles/895791.pdf
- Data publikacji:
- 2020-05-29
- Wydawca:
- Gdański Uniwersytet Medyczny
- Tematy:
-
cardiac surgery
acute respiratory distress syndrome
cardiopulmonary bypass
LBP1 rs2232582 - Opis:
- Background: Acute respiratory distress syndrome (ARDS) is a serious complication after cardiac surgery with a variety of clinical risk factors. It was hypothesized that genome variants predispose these patients to it. Material and methods: A cohort of 509 adult Caucasians undergoing on-pump cardiac surgery were observed for postoperative ARDS defined by the Berlin definition. Clinical variables and 10 single-nucleotide variants of genes involved in inflammatory pathways were analyzed for associations with four groups, defined by paO2/fiO2 (PF) ratio: 1) no ARDS (PF > 300 mmHg), 2) mild ARDS (200 < PF ≤ 300 mm Hg), 3) moderate ARDS (100 < PF ≤ 200 mm Hg), and 4) severe ARDS (PF ≤ 100 mmHg). Variables remaining in trends at p < 0.05 were considered significant. Results: The prevalence of ARDS was 7.9%. Only LBP1 rs2232582 remained in a genotypic trend with ARDS aggravation (p = 0.08). Clinical variables associated with ARDS aggravation: impaired left ventricular ejection fraction (p = 0.04), pulmonary hypertension (p = 0.01), intraoperative hypotension (p = 0.009), and postoperative day 1 white blood cell count (p = 0.015). More aggravated ARDS was associated with longer mechanical ventilation (p=0.01) and length of stay in ICU (p = 0.002). Conclusions: The borderline association with LBP1 rs2232582 and the identified risk factors suggest possible involvement of the LPS-LBP1 pathway in ARDS of the INFLACOR cohort.
- Źródło:
-
European Journal of Translational and Clinical Medicine; 2020, 3, 1; 24-33
2657-3148
2657-3156 - Pojawia się w:
- European Journal of Translational and Clinical Medicine
- Dostawca treści:
- Biblioteka Nauki
Artykuł