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Tytuł:
Current recommendations for treatment and diagnosing of xerostomia in Sjögren’s syndrome
Autorzy:
Zablotskyy, Oleh
Tomczyk, Martyna
Błochowiak, Katarzyna
Powiązania:
https://bibliotekanauki.pl/articles/454735.pdf
Data publikacji:
2019
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
saliv
Sjögren syndrome
xerostomia
Opis:
Introduction. Xerostomia is one of the most common and disturbing adverse effects of systemic diseases and their therapies. This complication markedly increases the risk for dental caries, difficulties with chewing, swallowing and sleep disorders with a significant impact on the patient’s quality of life. Sjögren’s syndrome (SS) is a systemic autoimmune disease that primarily affects the exocrine glands, resulting in dryness of the mouth due to lymphocytic infiltration of the salivary glands. Aim. The aim of this paper is to present the current recommendations in diagnosing and treating SS-related xerostomia. Material and methods. Analysis of literature Results. For the assessment of SS-related xerostomia, only an unstimulated salivary flow with rates of 0.1 mL/min is included in the current SS classification criteria. Saxon test, sialography, ultrasonography of salivary glands play supporting function. Treatment of SS -related xerostomia includes an application of secretagogues and the implementation of specific dental prophylaxis measures. Adjuvant therapies include herbal remedies, photobiomodulation, and acupuncture. Conclusion. Treatment of SS requires multidisciplinary care. There is no fully effective treatment of xerostomia that provides immediate and long-lasting results.
Źródło:
European Journal of Clinical and Experimental Medicine; 2019, 4; 356-363
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Physiotherapeutic management of a patient with patellofemoral pain syndrome – a case report
Autorzy:
Ustarbowska, Katarzyna
Trybulec, Bartosz
Powiązania:
https://bibliotekanauki.pl/articles/454991.pdf
Data publikacji:
2018
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
patellofemoral pain syndrome excessive lateral pressure syndrome
runner’s knee
physiotherapy
kinesiotaping
Opis:
Introduction. Patellofemoral pain syndrome (PFPS) is a disorder of the front compartment of the knee joint with incompletely investigated, probably multifactorial pathogenesis. It mostly affects young people and runners. In patients with PFPS conservative management is a therapy of choice with fundamental importance of physiotherapeutic procedures. Therapy should be highly individualized and considering all possible factors that may cause PFPS symptoms. Aim. The aim of this report was presentation of management of a 23 year old female patient with PFPS that developed secondary to a knee sprain. The medical history, diagnostic and therapeutic procedures were thoroughly described, then obtained results were presented and thereafter discussed. Methods. Clinical assessment included functional and provocative tests of the patellofemoral joint as well as thigh and calf muscles tests, range of motion measurement of the knee joint and pain assessment using the VAS scale. Therapeutic management included 5 sessions of post-isometric muscle relaxation (PIR), mobilizations of the patella and applications of elastic tapes. Results. After 5 sessions of therapeutic management PFPS symptoms were significantly reduced. Pain did not occur during normal activity, whereas in heavy joint loading, it occurred later and was of lower intensity. Range of motion as well as subjective sense of joint stability was also improved. Conclusions. Individually adjusted conservative management based on PIR techniques, mobilizations of patella and kinesiotaping seems to be effective form of therapy for PFPS of functional nature
Źródło:
European Journal of Clinical and Experimental Medicine; 2018, 1; 68-75
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Osmotic demyelination syndrome in a patient with slowly equalized severe hyponatremia – a case report
Autorzy:
Rudnicka-Czerwiec, Julia
Bartosik-Psujek, Halina
Powiązania:
https://bibliotekanauki.pl/articles/454969.pdf
Data publikacji:
2019
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
alcoholism
osmotic demyelination syndrome sodium
Opis:
Introduction. Osmotic demyelination syndrome (ODS), or central pontine myelinolysis (CPM), is a complication of severe and prolonged hyponatremia, particularly when hyponatremia is corrected too rapidly. However, even slow correction of hyponatremia can result in ODS. Aim. In this paper, we describe a patient who developed ODS following slow correction of hyponatremia. Description of the case. This article describes a case of chronic hyponatremia occurring in the course of alcoholism. The patient was admitted in severe condition with extremely low sodium level. Electrolyte supplementation was carried out according to the European Renal Best Practice (ERBP) guidelines; however, there was a rapid increase in sodium level leading to the development of symptomatic osmotic demyelinating syndrome. Following several weeks of rehabilitation and supplementation of B vitamins, the patient’s condition gradually improved. Conclusion. Sodium deficiency should be equilibrated very carefully, especially in patients with chronic hyponatremia in the course of alcoholism. Even small doses of sodium administered in accordance with the guidelines in chronic hyponatremia can cause a rapid increase in serum sodium level resulting in osmotic demyelination syndrome.
Źródło:
European Journal of Clinical and Experimental Medicine; 2019, 4; 371-377
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Serum levels of vitamin D and tumour necrosis factor-alpha in adults with metabolic syndrome
Autorzy:
Rahamon, Sheu Kadiri
Arinola, Olatunbosun Ganiyu
Charles-Davies, Mabel Ayebatonyo
Akinlade, Kehinde Sola
Olaniyi, John Ayodele
Fasanmade, Adesoji Adedipe
Oyewole, Oyediran Emmanuel
Owolabi, Mayowa Ojo
Adebusuyi, Jane Roli
Hassan, Olufunke Olayemi
Ajobo, Muhammed Babatunde
Adigun, Kehinde
Ebesunun, Maria Onomaghuan
Popoola, Omolara Olutosin
Omiyale, Wemimo
Agbedana, Emmanuel Oluyemi
Powiązania:
https://bibliotekanauki.pl/articles/2040233.pdf
Data publikacji:
2021-12-30
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
metabolic syndrome
vitamin D
inflammation
Opis:
Introduction. Reports continue to show that a significant association exists between serum vitamin D level and metabolic syndrome (MS)-associated inflammation. However, information on the serum levels of vitamin D and alterations in inflammation in different vitamin D status is presently lacking. Aim. To determine the serum levels of vitamin D and TNF-α, and assess their possible relationship with gender in individuals with MS. Material and methods. Sixty adults with MS and 40 controls were enrolled into this case-control study. Serum vitamin D and TNF-α levels were measured and participants stratified into different vitamin D status. Results. None of the participants had vitamin D deficiency and the mean vitamin D level was similar in MS compared with the controls. However, TNF-α level was significantly higher in MS compared with the controls. Serum vitamin D level had significant inverse correlation with serum TNF-α level in MS. Also vitamin D level was significantly lower while TNF-α level was significantly higher in female-MS compared with the male-MS. Conclusion. Adults with MS have elevated TNF-α level which appears to be associated with the serum level of vitamin D. Also, females with MS have low vitamin D level and this may exacerbate the MS-associated inflammation in them.
Źródło:
European Journal of Clinical and Experimental Medicine; 2021, 4; 306-312
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Favre-Racouchot syndrome and chronic obstructive pulmonary disease – a common link
Autorzy:
Imran Shamsi, Mohd
Dawar, Sachet
Ishtiyaq Shaafie, Harris
Chaudhry, Arun
Powiązania:
https://bibliotekanauki.pl/articles/2216795.pdf
Data publikacji:
2022-12-30
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
comedones
COPD
Favre-Racouchot syndrome
Opis:
Introduction and aim. Favre-Racouchot syndrome though mostly reported in Caucasian men (with an estimated prevalence of 6% in adults older than 50 years), cases have been reported in dark-skinned population including Indians, albeit rarely. It is characterized by large open and closed comedones along with epidermal cysts over the nose, cheeks, temples, forehead and periorbital areas. The association of this condition with chronic heavy smoking is what it makes compelling. Description of the case report. We report a case of elderly male, chronic heavy smoker who was diagnosed as a case of chronic obstructive pulmonary disease (COPD) as per standard guidelines. He presented with multiple nodulo-cystic lesions and had undergone a skin biopsy. Histomorphology features were consistent with Favre-Racouchot syndrome. Conclusion. Early identification of this skin condition in mildly symptomatic and asymptomatic smokers may help clinicians to forewarn the patients regarding development of chronic obstructive pulmonary disease (COPD).
Źródło:
European Journal of Clinical and Experimental Medicine; 2022, 4; 478-481
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Non-specific low back pain – what does it exactly mean? A proposed redefinition and classification of the problem
Autorzy:
Małecki, Jacek
Powiązania:
https://bibliotekanauki.pl/articles/454759.pdf
Data publikacji:
2017
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
low back pain
classification
triage syndrome
Opis:
Introduction. Analysis of the medical literature shows that non-specific low back pain is a multifaceted affliction. Determining the unequivocal definition and classification of the ailment could be somewhat difficult. The following review presents a multiplicity of common low back pain nuances. The paper also shows necessity of unification of the definition and clarification, for placing non-specific low back pain among other musculoskeletal disorders. Aim. The author will attempt to provide the answers to basic questions about non-specific low back pain. In its form, the paper will have similarities to the prospect study with narrative review features. Although the reader should remember that the article is neither a result of expert team efforts nor non-specific low back pain leading authority opinion. Therefore the suggestions should be interpreted with necessary distance and scientific scepticism. Material and methods. Proper publications were searched in PubMed and EBSCO scientific articles databases, using terms: ‘nonspecific low back pain’ or ‘non-specific low back pain’, ‘definition’, ‘diagnostic triage’, and ‘classification’ in different combinations. Results. As a result of the review, subtle correction of the current non-specific low back pain definition has been proposed. Acknowledgments. The author of this review wishes to show his appreciation to Prof. Edward Saulicz, the promotor and mentor for didactic support, methodologic and merythoric advice, and for manuscript correction. Thanks also extended to colleague Łukasz Sejboth, master of physiotherapy, for help with appropriate references and motivation to scientific exploration with his unassailable attitude and professionalism. Furthermore, author would like to acknowledge Keith Littlewood for his kind and valid amendments in the English version of the manuscript.
Źródło:
European Journal of Clinical and Experimental Medicine; 2017, 4; 349-355
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
A patient with overlap syndrome: systemic lupus erythematosus, dermatomyositis, and Sjögren’s syndrome – a rare overlapping diseases case report
Autorzy:
Sokołowska, Aldona
Iwański, Mateusz
Dąbrowski, Piotr
Powiązania:
https://bibliotekanauki.pl/articles/29519533.pdf
Data publikacji:
2023-09-30
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
autoimmune diseases
overlap syndrome
self-reactive
Opis:
Introduction and aim. Autoimmune rheumatic diseases are a group of disorders with similar clinical, laboratory and immunological manifestations. Connective tissue diseases include systemic scleroderma, dermatomyositis or polymyositis, Sjögren’s syndrome, rheumatoid arthritis, and systemic lupus erythematosus. If the patient meets the diagnostic criteria for at least two of these diseases and has specific serologic markers, a diagnosis of overlap syndrome is possible. Description of the case. This case describes a 27-year-old man who had a history of paroxysmal fever, night sweats, erythema-like skin lesions on the forearms and lower legs, a feeling of progressive muscle weakness especially in the proximal muscles, and dry mouth. The patient was diagnosed with an overlap syndrome: systemic lupus erythematosus, dermatomyositis, and Sjögren’s syndrome. Conclusion. Overlap syndrome is difficult to treat due to its multisystem nature, requiring a symptomatic therapeutic approach and careful control of medication doses to reduce side effects while controlling disease activity.
Źródło:
European Journal of Clinical and Experimental Medicine; 2023, 3; 659-662
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Genetic study of a family with affected members with Waardenburg syndrome type 4 without Hirschsprung disease
Autorzy:
Sabetghadam Moghadam, Mitra
Rayat, Sima
Morovvati, Saeid
Powiązania:
https://bibliotekanauki.pl/articles/2037551.pdf
Data publikacji:
2020-06-30
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
EDN3 gene
Waardenburg syndrome
WS4
Opis:
Introduction. Waardenburg syndrome (WS) is an autosomally inherited disorder with the most common state compounding pigmentary abnormality and sensorineural deafness. The rarest type of the disease is WS4 with the general characteristic discriminated from other types by the attendance of Hirschsprung disease (HD). Among the several genes, one of the causative genes in WS4 is endothelin 3 (EDN3) with both autosomal recessive and dominant inheritance. Aim. The intention of the present study is to report a pathogenic mutation as the genetic cause of WS in an Iranian family with four patients without any segregation criteria for the type of the disease. Material and methods. In order to detect of causing gene or genes related to the disease, Whole exome sequencing (WES) technique in proband’s sample was done. To confirm the detected mutation in proband and some family members with or without the disease direct sequencing of END3 gene was performed using Sanger method. Results. Pedigree analysis suggested segregation of WS as an autosomal recessive trait in the family. WES analysis suggested a gene (EDN3) related to WS type 4B. DNA sequencing confirmed a pathogenic missense mutation c.293C>T, p.T98M in EDN3 gene in all of the four patients. Conclusion. Determination of WS can usually be missed owing to the lack of some attributes in every sufferer and also conventional clinical variance, in spite of several affected members in a single family. So, Genetic counseling is pivotal for families with multiple members influenced. We detected c.293C>T, p.T98K mutation in EDN3 gene as a pathogenic variant which has b een known as a likely pathogenic state in the American College of Medical Genetics and Genomics (ACMG) guidelines, despite one prior report. It will be helpful in genetic diagnosis of affected persons and increases the mutation spectrum of EDN3 gene.
Źródło:
European Journal of Clinical and Experimental Medicine; 2020, 2; 93-100
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Life quality of patients with the carpal tunnel syndrome
Autorzy:
Wolska, Joanna Michalik
Wolski, Dariusz
Bieńko, Marek
Radzki, Radosław P.
Powiązania:
https://bibliotekanauki.pl/articles/454906.pdf
Data publikacji:
2018
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
carpal tunel syndrome
quality of life
neuropathiers
Opis:
Introduction. Carpal tunnel syndrome (CTS) is a neuropathy caused by pressure on the median nerve taking a course in the carpal tunnel. The characteristic symptoms of CTS are: pain, numbness, and a prickling sensation in the hand usually at night or after the physical effort. Symptoms of the disease affect patient quality of life which is desribed as a subjective estimation of life situation. Aim. The aim of this study was to assess the quality of patient life in those who suffer from carpal tunel syndrome. The studies were aimed to descripe the general quality of patient life and the effect of symptoms on individual aspects in the life of the afflicted. Materials and methods. The study sample was composed of 60 patients from rehabilitation and physiotherapy institutions located in the Lublin Voivodship (Poland). The studies were based on the questionnaries of life quality estimation dependent on health WHOQOL- BREF and EQ-5D-5L as well as on our own poll questionnaire. Conclusions. Symptoms of carpal tunel syndrome deteriorate the quality of patient life. Such patients have difficulties with daily activities. Among those examined, as many as 94.12% reported problems performing everyday actions (EQ – 5D – 5L). Difficulties with chores were reported by 86.70% of those examined. The patients with carpal tunel syndrome are less effective at work. Reduced achievements at work were reported by 73.30% of those examined, and a need for a shorter work day was reported by 60%. For 53.30%, difficulties in doing their jobs were significant; 20% of the examined had to change their profession or work station. The examined patients often experienced pain which deteriorated quality of sleep and disturbed everyday functioning. The patients were presented with serious difficulties in doing professional work.
Źródło:
European Journal of Clinical and Experimental Medicine; 2018, 3; 217-223
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Acute pulmonary hypertension as a symptom of Bard’s syndrome and pulmonary lymphangitis carcinomatosa – rare manifestation of malignant gastric cancer
Autorzy:
Mazur, Danuta
Romanek, Janusz
Filip, Rafał
Przybylski, Andrzej
Powiązania:
https://bibliotekanauki.pl/articles/454787.pdf
Data publikacji:
2019
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
Bard’s syndrome
malignant gastric cancer
pulmonary hypertension
Opis:
Introduction. Acute pulmonary hypertension leading to right ventricular failure and circulatory collapse is usually caused by a pulmonary embolism. However, in extremely rare cases, similar clinical manifestations can be related to another diseases, such as lymphangitis carcinomatosa. Aim. The purpose of this paper is to report on the case of a 29-year-old male patient presented with rapidly progressing dyspnoea. Description of the case. The diagnosis of pulmonary embolism was made on the basis of echocardiographic signs of pulmonary hypertension and right ventricular (RV) dilatation, and the recommended therapy was introduced. On the suspicion of bronchopneumonia, antibiotics and steroids were applied. However, the previously stated diagnosis of pulmonary embolism was not confirmed by the angio-CT scan, which showed small diffusive lung parenchyma intra-biliary nodules (ground glass opacity) with the peripheral appearance of a tree-in-bud sign. Consecutive CT of pelvis and abdomen along with endoscopy revealed a metastatic gastric cancer with the presence of lymphangitis carcinomatosa and miliary dissemination to the lungs. The presence of pulmonary metastases in the course of disseminated gastric cancer is known in literature as Bard’s syndrome. Conclusion. Extrapulmonary malignancies, particularly gastric cancer, should be taken into consideration in differential diagnosis in patients with an acute right ventricular failure and nonspecific lesions in the respiratory system.
Źródło:
European Journal of Clinical and Experimental Medicine; 2019, 2; 179-183
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Labial salivary gland biopsy in the diagnosis of Sjögren’s syndrome
Autorzy:
Błochowiak, Katarzyna
Sokalski, Jerzy
Powiązania:
https://bibliotekanauki.pl/articles/454844.pdf
Data publikacji:
2019
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
biopsy
labial glands
salivary glands
Sjögren’s syndrome
Opis:
Introduction. Labial salivary gland biopsy is used for diagnosis of Sjögren’s syndrome (SS) and lymphoma accompanying SS. Aim. The aim of this study was to present the main techniques used for taking labial salivary gland biopsies in the diagnosis of SS with respect to their advantages, histologic criteria, validation, complications, and their usefulness for diagnostic procedures, monitoring disease progression, and treatment evaluation. Material and methods. This study is based on analysis of literature. Results. The microscopic confirmation of SS is based on the presence of focal lymphocytic sialadenitis (FLS) with a focus score ≥1 per 4 mm2 of glandular tissue. A lymphocytic focus is defined as a dense aggregate of 50 or more lymphocytes adjacent to normal-appearing mucous acini in salivary gland lobules that lacked ductal dilatation. Other histopathological features of SS are lymphoepithelial lesions and a relative decrease of <70% IgA + plasma cells. Labial salivary gland biopsy is characterized by high specificity, a positive predictive value, and an average sensitivity of 79% in SS. Conclusion. It can be also valuable in diagnosing B-cell mucosa-associated lymphoid tissue (MALT) lymphomas but it is not recommended for the monitoring of SS progression and the effectiveness of the treatment. Persistent lower lip hypoesthesia is the most severe complication of labial salivary gland biopsy.
Źródło:
European Journal of Clinical and Experimental Medicine; 2019, 2; 162-168
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Effect of meditation on premenstrual syndrome in female medical students
Autorzy:
Kaur, Harminder
Kaur, Nimarpreet
Reddy Akula, Gangadhar
Reddy Kodidala, Satyanath
Powiązania:
https://bibliotekanauki.pl/articles/27317665.pdf
Data publikacji:
2023-09-30
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
cold pressor test
meditation
premenstrual syndrome
serum cortisol
stress
Opis:
Introduction and aim. A symptom complex of cyclic irritability, depression and lethargy is known as the premenstrual syndrome (PMS). Since ages women suffered from PMS. As varied as the etiology, innumerable treatment modalities have been put forward for PMS. Stress is accompanied most closely associated in PMS. Practicing yoga and meditation significantly important for PMS symptoms in reducing its symptoms and period crams as well. The present study aims the impact of meditation in people with PMS. The aim of the study was to see any effect of Shavasana (meditation) training on stress parameters in premenstrual syndrome in female medical students. Material and methods. The present study was approved by institutional ethical committee. Thirty clinically healthy female medical students who were suffering from PMS selected using a premenstrual questionnaire. The values of heart rate, systolic and diastolic blood pressure, and serum cortisol were measured before meditation. Subjects were then taken through Shavasana (meditation) session for 4 weeks at the same time daily. On the last day of meditation session all above parameters were again recorded and the data was analyzed statistically. Results. The baseline values of all parameters in premeditation session compared to post meditation session. The basal SBP, DBP and HR of female medical students with PMS were significantly higher in pre meditation session than post meditation session with p value of SBP=0.0002, DBP=0.0001, HR<0.0001 respectively which indicated the presence of stress. Following a 4 weeks of Shavasana meditation a significant fall in baseline SBP, DBP, HR and the serum Cortisol value was observed. Conclusion. These findings proves that Shavasana is an effective treatment modality to get rid of stress during premenstrual phase
Źródło:
European Journal of Clinical and Experimental Medicine; 2023, 3; 529-533
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Membrane lipids under norm and pathology
Autorzy:
Marzoog, Basheer Abdullah
Ivanovna Vlasova, Tatyana
Powiązania:
https://bibliotekanauki.pl/articles/2040262.pdf
Data publikacji:
2021-03-30
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
cholesterol
lipid distress syndrome
membrane lipids, peroxidation phosphatidylcholine plasmenylethanolamine
Opis:
Introduction. Lipid is an essential component of the cell and its organelles membrane. The uniqueness and selectivity of lipids to specific functions and asymmetry of lipid distribution in the organelle’s membrane give the cell ability of being highly qualified and specified. Aim. The paper provides a comprehensive review of membrane lipids in different tissues and organelles of the cell in norm and disease. Material and methods. The paper analyzed the present literature data on membrane lipids behavior in physiology and pathology. Analysis of the literature. The major structural and functional lipids of the cell membrane are phosphatidylcholine > phosphatidylethanolamine. The absence/deficiency or augmentation of a specific type of lipid results in serious defects and usually life-threatening with a permanent disability. The observations discussed here suggest, the lipid peroxidation severity depends on the membrane lipid composition of the cell. Some tissue cells can handle lipoperoxidation and protect themselves from the peroxidation damaging products better, while other cells cannot compensate. Therefore, some organs are highly sensitive to peroxidation and irreversible changes occur rapidly. Conclusion. To sum up, the understanding of lipid’s role in norm and disease is clinically crucial to evaluate a novel therapeutic target to treat many metabolic disorders such as metabolic syndrome and some lysosomal storage disorders via targeting specific new signaling pathways, lipid molecules, and enzymes
Źródło:
European Journal of Clinical and Experimental Medicine; 2021, 1; 59-75
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Ramsay Hunt syndrome with deep hearing loss and meningitis
Autorzy:
Błochowiak, Katarzyna
Kamiński, Bartłomiej
Powiązania:
https://bibliotekanauki.pl/articles/454755.pdf
Data publikacji:
2018
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
s. facial palsy
hearing loss
meningitis
Ramsay Hunt syndrome
Opis:
Introduction. Ramsay Hunt syndrome is a clinical manifestation of varicella zoster virus reactivation. It is characterized by an erythematous vesicular rash in the external auditory canal and pinna with otalgia, vertigo and ipsilesional facial palsy. Symptoms develop over a few days with prodromal signs of facial weakness, tingling, facial numbness. Usually, cranial nerves VII and VIII are involved in the inflammatory process. Possible consequences of Ramsay Hunt syndrome are hearing loss, encephalitis and meningitis. Description of the case report. The authors present the case of a 63-year-old woman with a vesicular rash, earache, vertigo and left-sided facial paralysis who was treated with antiviral drugs and analgesics. These symptoms were complicated by conductive hearing loss in the left ear and meningitis. After treatment facial paralysis decreased. Unfortunately, hearing loss was permanent. Discussion. Rapid administration of antivirals and corticosteroids limited facial paralysis and improved facial expression. The prognosis for facial palsy is poorer in Ramsay Hunt syndrome than in idiopathic forms. Conclusions. A past history of vertigo and hypertension could been a predisposing factor for the severe manifestation of Ramsay Hunt syndrome and subsequent complications
Źródło:
European Journal of Clinical and Experimental Medicine; 2018, 1; 60-62
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Pathophysiology of thromboembolism in patients with COVID-19
Autorzy:
Vityala, Yethindra
Krishna, Abhijit
Pandla, Dinesh
Kanteti, Krishna Priya
Sadhu, Jahnavi
Boddeti, HarshaVardhan
Kintali, Tejesh
Khalid, Mohammad Shaour
Powiązania:
https://bibliotekanauki.pl/articles/2075063.pdf
Data publikacji:
2022-06-30
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
acute respiratory distress syndrome
COVID-19
pathophysiology
pulmonary embolism
thromboembolism
Opis:
Introduction and aim. A small number of critically ill patients with coronavirus disease (COVID-19) develop thromboembolism (arterial or venous), both micro- and macrovascular complications such as deep vein thrombosis, pulmonary embolism, and pulmonary arterial thrombosis. The objective of the study is to describe the pathophysiology of venous thromboembolism in patients with COVID-19. Material and methods. In this article a narrative review regarding pathophysiology of thromboembolism in patients with COVID-19. Analysis of the literature. The development of coagulopathy is a consequence of the intense inflammatory response associated with hypercoagulability, platelet activation, and endothelial dysfunction. The pathophysiology that relates pulmonary thromboembolism (PTE) with COVID-19 is associated with a hypercoagulable state. PTE is suspected in hospitalized patients presenting dyspnea, decreased oxygen requirement, hemodynamic instability, and dissociation between hemodynamic and respiratory changes. In COVID-19-associated coagulopathy, initially, patients present with elevated levels of fibrinogen and D-dimer, with minimal changes in prothrombin time and platelet count. The main risk factor for the development of pulmonary embolism is the increase in D-dimer that is associated with the development of PTE. The administration of iodine-based contrast agent to patients with COVID-19 would affect P-creatinine and renal function, where Ultrasound is viewed as cost-effective and highly portable, can be performed at the bedside. Conclusion. Acute respiratory distress syndrome severity in patients with COVID-19 can explain PTE as a consequence of an exaggerated immune response.
Źródło:
European Journal of Clinical and Experimental Medicine; 2022, 2; 212-216
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Wyświetlanie 1-15 z 19

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