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Wyświetlanie 1-15 z 103
Tytuł:
Plasma level of beta endorphin in seborrheic dermatitis patients
Autorzy:
Vysochanska, Vlasta
Koval, Galina
Powiązania:
https://bibliotekanauki.pl/articles/29520455.pdf
Data publikacji:
2023-12-31
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
itch
seborrheic dermatitis
beta-endorphin
Opis:
Introduction and aim. Defects in the epidermal barrier, changes in sebum secretion and its composition, Malassezia spp. overgrowth, endocrine, immune, and neurological disorders are the main pathogenesis items of seborrheic dermatitis (SD). “The opioid system of the skin” was considered a new target in the diagnosis and treatment of SD. The study aimed to determine beta-endorphin (BE) levels in adult patients with seborrheic dermatitis and correlate them with the severity of symptoms and itching. Material and methods. 26 healthy and 62 SD people were examined. SEDASI scale were used to estimate the severity of symptoms and intensity of itching. The determination of the beta-endorphin level was carried out by the ELISA method with the test system Human BE NBP2 (78774 Novus Biologicals). Results. BE in the SD group was higher compared to the control group (35.5 pg/mL, 22. pg/mL, p<0.001). The level of BE in seborrheic patients did not depend on age and sex but was rising with severity of symptoms. Positive correlations were found between the level of BE and the SEDASI was 0.42 (p<.001), between the level of BE and itching was 0.332 (p=0.009). Conclusions. SD patients have an increased level of BE that positively correlates with itching and disease severity.
Źródło:
European Journal of Clinical and Experimental Medicine; 2023, 4; 704-710
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Inference of oxidative stress in patients with hypothyroidism
Autorzy:
Rada, Feryal
Powiązania:
https://bibliotekanauki.pl/articles/40555549.pdf
Data publikacji:
2024-06-30
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
glutathione
hypothyroidism
malondialdehyde
oxidative stress
paraoxonase-1
Opis:
Introduction and aim. Oxidative stress is one of the complications that accompany defects in thyroid hormone levels. This study was designed to evaluate oxidative stress markers in patients with hypothyroidism. Material and methods. This case control study was comprised of forty-two hypothyroid patients aged 36–46 years and forty age matched (35–43 years) healthy control participants randomly selected from the Endocrine Clinic of Al-Yarmook Hospital in Iraq. Blood levels of thyroid hormones malondialdehyde, glutathione, and paraoxonase-1 were assessed. Body mass index was calculated for each patient and control participant. Results. Regarding the data of oxidative stress markers in hypothyroid patients compared to controls, a significant elevation was reported in blood levels of malondialdehyde and a significant reduction was found in blood levels of glutathione (p=0.031). On the other hand, the blood levels of paraoxonase-1 were significantly different in hypothyroid patients compared with the control. Conclusion. Elevated blood levels of malondialdehyde and declined blood levels of glutathione in hypothyroid patients are a signal of oxidative stress and consequently increase the risk of cardiovascular complications.
Źródło:
European Journal of Clinical and Experimental Medicine; 2024, 22, 2; 270-274
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Drug-induced thrombocytopenia – etiology and alternative therapeutic approaches
Autorzy:
Rajashekaraiah, Vani
Berikai Ananthakrishna, Anusha
Powiązania:
https://bibliotekanauki.pl/articles/29519508.pdf
Data publikacji:
2023-09-30
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
alternative therapeutics
drug-induced thrombocytopenia
phytochemicals
platelets
Opis:
Introduction and aim. The cumulative incidence of drug-induced thrombocytopenia (DIT) is 10 cases per one million people per year with a prevalence of approximately 25% in critically ill patients. This review provides a comprehensive view of drug-induced thrombocytopenia, diagnosis, underlying mechanisms, common strategies in therapeutics, and potential alternatives. Material and methods. Databases such as “Google Scholar”, “PubMed”, “Medline” and “MDPI” was used for literature review with the keywords, “platelets”, “platelet disorders”, “thrombocytopenia”, “drug-induced”, “oxidative stress” “plant extracts”, “phytochemicals”, “antioxidants”, for the articles published between 2013-2023 and written in the English language. Analysis of the literature. Several antimicrobials, anti-cancer drugs, and antivirals are often reported to cause adverse effects during treatment, such as thrombocytopenia. A thorough understanding of the underlying pathophysiology is important for appropriate treatment. Even though an improvement in platelet count is observed after the discontinuation of the causative drug, there is a dire need for treatment in some cases due to associated complications. There are various pitfalls with conventional treatments which include clinical complications and lack of effectiveness. Conclusion. Interventions in therapeutics through antioxidants can aid in faster recovery. Various plant extracts and phytochemicals have been employed as therapeutics in platelet disorders due to their exceptional antioxidant activity. It is imperative to explore the bioactive components of natural products and their influence on platelet efficacy. Also, it highlights how antioxidants can be used as a safe, yet effective option as therapeutics for treating a complicated disorder such as DIT or be used as supplements to prevent adverse effects of existing treatments involving antibiotics and chemotherapeutics.
Źródło:
European Journal of Clinical and Experimental Medicine; 2023, 3; 617-626
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Evaluation of the relationship between job satisfaction and professional behaviors in pediatric nurse
Autorzy:
Dinç, Fatma
Yıldız, Dilek
Powiązania:
https://bibliotekanauki.pl/articles/29519427.pdf
Data publikacji:
2023-09-30
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
job satisfaction
nursing professionalism
pediatric nurses
Opis:
Introduction and aim. Pediatric nurses play an important role in ensuring quality healthcare through job satisfaction and professional behaviors. This study aims to examine the relationship between job satisfaction and professional behaviors in pediatric nurses. Material and methods. This was a descriptive and cross-sectional study. The sample of the study consisted of 244 pediatric nurses who worked in tertiary university hospitals in Turkey and agreed to participate in the study. Data were obtained through face-to-face interviews using a personal information form, the job satisfaction scale for nurses (JSSN), and the behavioral inventory form for professionalism in nursing (BIPN). Data were analyzed using the SPSS 22.0 software and evaluated using descriptive statistics, independent t-tests, one-way ANOVA, Pearson correlation, and simple linear regression analysis. Results. The nurses’ JSSN and BIPN means scores were 3.42±0.59 and 5.69±4.05, respectively. A statistically significant moderate positive relationship was found between the pediatric nurses’ professional behaviors and job satisfaction (R=0.342; p<0.001). The regression analysis revealed that professional behaviors significantly and positively influenced job satisfaction in pediatric nurses (β=0.050; p<0.001). Conclusion. This study found that pediatric nurses had a moderate level of job satisfaction and a low level of professional behaviors, and as their professional behavior increased, their job satisfaction also increased.
Źródło:
European Journal of Clinical and Experimental Medicine; 2023, 3; 553-560
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Oxidative stress and antioxidants markers in individuals with thyroid hormones dysfunction
Autorzy:
Omon, Emmanuel Akokhamen
Ajay, Olawale David
Powiązania:
https://bibliotekanauki.pl/articles/29520465.pdf
Data publikacji:
2023-12-31
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
antioxidants
dysfunction
malondialdehyde
oxidative stress
thyroid hormone
Opis:
Introduction and aim. Thyroid hormone abnormalities have been associated with oxidative changes in human beings. The aim of the study was to evaluate the oxidative stress marker and antioxidants status in individuals with thyroid hormone dysfunction in Ekiti State. Material and methods. A total of eighty samples were recruited in this study comprising forty subjects with thyroid hormones dysfunction and forty apparently healthy controls. Malondialdehyde (MDA), reduced glutathione (GSH) and catalase were determined spectrophotometerically. Results. MDA was non-significantly higher (p>0.05) in subjects (4.33±0.84 nmol/mL) compared with control (4.12±0.63 nmol/mL), catalase was non-significantly higher (p>0.05) in subjects (199.36±20.21 µm/mL) compared with control (181.55±16.61 µm/mL), while GSH was significantly lower (p<0.05) in subjects (79.31±10.12 µmol/mL) compared with control (127.21±7.29 µmol/mL). Conclusion. It can be concluded that the increase in the reactive oxygen species accompanied with impairment of the antioxidant system occurs in patients with thyroid hormone dysfunction. Hypothyroidism and hyperthyroidism induces disequilibrium of the oxidative/anti-oxidative balance that can lead to subsequent development of inflammation and associated diseases.
Źródło:
European Journal of Clinical and Experimental Medicine; 2023, 4; 768-775
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Turkish cross-cultural adaptation of Pediatric Transition Experience Measure
Autorzy:
Kurt, Aylin
Dinç, Fatma
Güneş Şan, Emine
Powiązania:
https://bibliotekanauki.pl/articles/40570857.pdf
Data publikacji:
2024-06-30
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
measure
parents
pediatric transition
reliability
validity
Opis:
Introduction and aim. The period immediately after leaving the hospital is known as the transition home, which presents a critical time for parents to take on all the responsibilities and care of a child without the support of the hospital environment. The purpose of this study is to culturally adapt the Pediatric Transition Experience Measure (P-TEM) instrument into Turkish and test its validity and reliability. Material and methods. We conducted this methodological study with parents of children who were discharged from the hospital between May 2021 and May 2022. We evaluated linguistic, content, construct, convergent validity, and internal consistency. Results. The P-TEM exhibited a two-factor structure and accounted for 65% of the overall variability. The internal consistency reliability for the transition preparation and transition support subdimensions was 0.779 and 0.793, respectively, while the total measure had a reliability of 0.831. The item-total correlations for the P-TEM ranged from 0.493 to 0.671. Parents who received the highest P-TEM scores experienced a 5.1-point improvement (95% confidence interval: 1.7 to 8.6) in their satisfaction with healthcare services, which was greater than that of parents who reported lower P-TEM scores. Conclusion. It is worth noting that the P-TEM has been validated and has high reliability in Türkiye.
Źródło:
European Journal of Clinical and Experimental Medicine; 2024, 22, 2; 320-326
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
A study of etiological spectrum in 106 cases of pancytopenia
Autorzy:
Singhal, Parul
Mittal, Adreena
Dixit, Ritvija
Powiązania:
https://bibliotekanauki.pl/articles/40570864.pdf
Data publikacji:
2024-06-30
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
anemia
aplastic
leucopenia
megaloblastic
pancytopenia
thrombocytopenia
Opis:
Introduction and aim. Pancytopenia is the simultaneous presence of anemia, leucopenia and thrombocytopenia. The aim of this work was to study the etiological spectrum of pancytopenia in the National capital region of India, and evaluate the relationship of pancytopenia with serum vitamin B12 levels. Material and methods. This study is of a prospective and analytical type conducted on patients attending the outpatient and inpatient department of Santosh Medical College and the Saraswathi Institute of Medical Sciences tertiary care centers in NCR. Complete blood counts and peripheral blood smear examination was used for morphological classification and typing of anemia. Bone marrow aspiration and vitamin B12 estimation was performed where required. Results. The maximum number of pancytopenia cases were etiologically attributed to megaloblastic anemia (64.2%) followed by aplastic anemia (19.8%). Malaria was attributed to 6.6% cases of pancytopenia. Iron deficiency anemia and tuberculosis both accounted for 1.9% of cases. each. A history of drug intake and mixed nutritional anemia each contributed to 2.8% of cases. Serum vitamin B12 levels showed a significant relationship with pancytopenic cases. Conclusion. In our study, the main cause of pancytopenia is megaloblastic anemia which responds very well to treatment if diagnosed correctly in time. A detailed hematological assessment along with vitamin B12 levels should be evaluated in all cases of pancytopenia irrespective of the etiological categorization.
Źródło:
European Journal of Clinical and Experimental Medicine; 2024, 22, 2; 370-375
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Genetic factors contributing to the development of inguinal hernias – a narrative review
Autorzy:
Kalali, Datis
Powiązania:
https://bibliotekanauki.pl/articles/40614533.pdf
Data publikacji:
2024-06-30
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
genes
genetics
genome-wide association
inguinal hernias
polymorphisms
studies
Opis:
Introduction and aim. Inguinal hernias are one of the major disorders in the field of general and visceral surgery and can be viewed as multifactorial diseases. Although the molecular mechanism that led to predistortion to inguinal herniation still remain unclear, is well known that defects leading to improper closure of the inguinal canal during fetal development and mechanisms contributing to weaker muscles of the abdominal wall can greatly increase the risk of developing the latter disease. Material and methods. A literature search was performed in all major electronic databases using keywords and Boolean operators to retrieve all available literature related to the topic. Due to the narrative nature of the review, there were no specific inclusion and exclusion criteria. Analysis of the literature. Genetic factors, undoubtedly, can interfere with these mechanisms and therefore play major role in developing hernias. To this end, the present narrative review provides an overview of genes with altered expression and genetic polymorphisms associated with inguinal herniation. Moreover, the results of genome-wide association studies (GWAS) exploring susceptible genetic loci associated with the disease have been reported. Conclusion. Nevertheless, more case-control studies and GWAS need to be conducted in different ethnic populations so as to provide better insights into the topic.
Źródło:
European Journal of Clinical and Experimental Medicine; 2024, 22, 2; 417-423
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
From diagnosis to recovery – a detailed case report on a nail bed glomus tumor
Autorzy:
Shaafie, Harris I.
Powiązania:
https://bibliotekanauki.pl/articles/40614536.pdf
Data publikacji:
2024-06-30
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
glomus tumor
subungual
transungual nail excision
Opis:
Introduction and aim. Glomus tumors represent benign neoplastic proliferations of the glomus body, an integral thermoregulatory component within the cutaneous microvasculature. Although they can manifest at various anatomical sites, they are predominantly observed in the subungual region. The tumors present as painful, firm, purplish, solitary nodules of the extremities, especially in the nail bed. They may be solitary or multiple; solitary lesions are encapsulated and most commonly subungual, while multiple tumors are unencapsulated and rarely subungual. Description of the case. Here, we present a case of multiple glomus tumors of the right hand in an 18-year-old female who presented with complaints of painful bluish discoloration of the right little finger for six years and progressive asymptomatic nodules on the right index finger for six months. A clinical examination revealed acute tenderness in both fingers. Love’s pin test and Hildreth’s test were positive. Excision of all lesions was done and sent for histopathology, which confirmed the diagnosis. The patient was symptom-free immediately following surgery. No nail deformities were noticed, and there was no recurrence of symptoms after one year of follow-up. Conclusion. The transungual approach is a safe and effective minimally invasive surgical technique for the treatment of symptomatic nail bed glomus tumors. It offers high success rates, promising cosmetic outcomes, and minimal complications. However, careful patient selection and meticulous surgical technique are essential to avoid potential nail deformities.
Źródło:
European Journal of Clinical and Experimental Medicine; 2024, 22, 2; 439-441
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Stigma and its relationship with life satisfaction in patients with type 2 diabetes mellitus
Autorzy:
Turen, Sevda
Yurtsever, Melike
Powiązania:
https://bibliotekanauki.pl/articles/40418503.pdf
Data publikacji:
2024-03-30
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
life satisfaction
stigma
type 2 diabetes mellitus
Opis:
Introduction and aim. This study aims to determine the level of stigma in patients with type 2 diabetes mellitus (T2DM) and evaluate its relationship with their life satisfaction. Material and methods. This is a descriptive and cross-sectional study conducted in a single tertiary care center. Two hundred and ten patients ≥18 years old diagnosed with T2DM were included in this study. The relationship between the “Type 2 diabetes stigma assessment scale” and the “Satisfaction with life scale” was assessed using Pearson correlation analysis. Results. The average age of the participants was 54.85±15.81 years. The majority of patients reported adherence to diabetes treatment and having comorbidities. Stigma levels were higher in patients ≤65 years, those with less than a high school education, and those receiving insulin or oral anti-diabetic treatment, but lower with a T2DM diagnosis duration of ≤ 5 years (p<0.05). Life satisfaction was influenced by age, education status, economic status, adherence to treatment, dietary compliance, and the presence of comorbidities. A moderately negative relationship between stigma level and life satisfaction was identified. Conclusion. The study’s results indicate that an increase in stigma level is associated with a decrease in life satisfaction in patients with type 2 diabetes mellitus.
Źródło:
European Journal of Clinical and Experimental Medicine; 2024, 22, 1; 128-133
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Caring and therapeutic services – a patient’s opinion on experience and satisfaction with night nursing care
Autorzy:
Fąfara, Anna
Krakowiak-Burdzy, Anna
Powiązania:
https://bibliotekanauki.pl/articles/40419499.pdf
Data publikacji:
2024-03-30
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
care
nursing service
patient
Opis:
Introduction and aim. Night nursing care ensures well-being, peace, and security allowing a patient to enter into the deep sleep phase. This study aims to analyze the relationship between an assessment of caring and therapeutic services and the opinion of in-patients on their experience and satisfaction with night nursing care. Material and methods. A questionnaire developed by the authors and the Newcastle Satisfaction with Nursing Scale were used in this study. This study was conducted in the eastern region of Poland in the Podkarpackie province. The study included 585 patients. Results. Tasks analyzed resulting from care and therapeutic functions, in the patient’s opinion, had a significant impact on the overall assessment of nursing care. Meeting the expectations regarding night rest (experience of nursing care) and satisfaction showed the strongest correlation. Tasks resulting from therapeutic functions showed an average correlation with the exception of planned medical care. Conclusion. The level of implemented health services by nurses at night significantly influences the overall assessment of the quality management system in health care.
Źródło:
European Journal of Clinical and Experimental Medicine; 2024, 22, 1; 147-153
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Comparison of algorithms for detection of active inflammatory lesions in sacroiliitis
Autorzy:
Gawłowski, Igor
Ożga, Joanna
Raczko, Agata
Powiązania:
https://bibliotekanauki.pl/articles/40521367.pdf
Data publikacji:
2024
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
artificial intelligence
axial spondyloarthritis
bone marrow edema
Opis:
Introduction. Artificial intelligence is increasingly being used in the medicine, particularly in radiological diagnosis of diseases such as an axial spondyloarthritis (axSpA). The aim of this study is to compare the available algorithms designed to detect active sacroiliitis in patients with axSpA. Material and methods. Four algorithms, two semi-automated and two full-automated for the assessment of bone marrow edema (BME) on magnetic resonance imaging (MRI) of the sacroiliac joints (SIJs) were included in the study. They were described and compared in terms of specificity, sensitivity, and correlation of BME detection findings between AI and experts. Analysis of the literature. Among all automated algorithms, the one created by Bressem et al. had the highest number of examinations analyzed in the study, involving 593 MRIs of SIJs. The sensitivity and specificity, as well as the correlation between the AI’s detection of BME versus manual, were not calculated for each algorithm. Rzecki’s algorithm had the greatest sensitivity and specificity for BME detection reaching 0.95 and 0.96, respectively. In addition, its Speraman’s coefficient of correlation between manual and automated measurements was 0.866. Conclusion. Each of described algorithms is certainly useful in assessing BME in the MRI examinations of SIJs.
Źródło:
European Journal of Clinical and Experimental Medicine; 2024, 22, 1; 188-193
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Nutritional knowledge about the Mediterranean diet and its practical application among students in Poland
Autorzy:
Karlik, Sandra
Dereń, Katarzyna
Powiązania:
https://bibliotekanauki.pl/articles/29519512.pdf
Data publikacji:
2023-09-30
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
Mediterranean diet
nutrition
students’ knowledge
Opis:
Introduction and aim. The popularity of the Mediterranean diet is increasing and following it has many health benefits, including improving mental well-being. The aim of the study was to assess the nutritional knowledge about the Mediterranean diet and its practical application among students in Poland. Material and methods. The study assessed a group of 313 students in Poland. The research tool was a questionnaire that focused on knowledge about the Mediterranean diet. Results. The study showed that in terms of knowledge of the Mediterranean diet, students scored on average 6.5±3.2 points (on a scale 0–11). When it comes to dietary compliance, the average score was 6.3±2.4 points (scale 1–13 points). The better the knowledge of the diet, the better the compliance with its rules. Statistically, the analysis showed that there is a significant relationship between the age and/or academic degree of the students and their higher level of knowledge. The greater compliance with Mediterranean eating patterns was influenced by the location, age, or education of the respondents. Conclusion. The study shows that the surveyed group of students in Poland has only an average level of knowledge and compliance with the Mediterranean diet.
Źródło:
European Journal of Clinical and Experimental Medicine; 2023, 3; 483-491
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Characteristics of patients with cerebral aneurysms and arteriovenous malformations
Autorzy:
Ożga, Joanna
Skiba, Marcin
Sztuczka, Szymon
Wyka, Michał
Powiązania:
https://bibliotekanauki.pl/articles/40556251.pdf
Data publikacji:
2024-06-30
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
aneurysm
arteriovenous malformation
digital subtraction angiography
Opis:
Introduction and aim. Aneurysms and arteriovenous malformations (AVMs) are both vascular abnormalities that can occur simultaneously or separately and increase the risk of intracerebral hemorrhage. The aim of this research was to characterize patients with intracranial aneurysms and AVMs. Material and methods. This retrospective research was based on analysis of Digital Subtraction Angiography. The research group consisted of 118 patients. StatSoft STATISTICA 13 was used for the statistical analysis of parameters, such as dimensions and vascularization pattern of vascular abnormalities. Results. The total number of aneurysms described was 168. In addition, 33 patients with cerebral aneurysms were also diagnosed with cerebral AVMs. The average dimensions of the aneurysms were 6.33mm, 95% CI (5.47 7.18) × 4.76mm, 95% CI (4.09, 5.43). The abnormalities were found in the extent of circulation of ACA (anterior cerebral artery) 50 (29.76%), ICA (internal carotid artery) 48 (28.57%), MCA (middle cerebral artery) 26 (15.48%), PCA (posterior cerebral artery) 23 (13.69%). There were 76 (64%) patients with diagnosed single aneurysms and 42 (36%) with multiple. Conclusion. Aneurysms are more likely to occur singly than multiply. The majority are located within the vascularization of the ACA. Aneurysms can coexist with AVMs, which increases the risk of rupture.
Źródło:
European Journal of Clinical and Experimental Medicine; 2024, 22, 2; 286-291
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Synthesis and characterization of Fulvestrant and Paclitaxel conjugates with polyamidoamine dendrimer fourth generation
Autorzy:
Wróbel, Konrad
Wołowiec, Stanisław
Powiązania:
https://bibliotekanauki.pl/articles/29519437.pdf
Data publikacji:
2023-09-30
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
PAMAM dendrimer
double-conjugation
Fulvestrant
Paclitaxel
anticancer drug delivery system
Opis:
Introduction and aim. Poorly soluble anticancer drugs can be attached covalently into biologically inert macromolecule in order to administrate a drug as water soluble form. It was proven that covalent linkers, for instance amide or carbamate bonds are susceptible to hydrolysis. Thus the attached drug can be released from the conjugates in tissue, specifically within the targeted cell. We aimed at construction of water soluble conjugates of Fulvestrant and Paclitaxel with PAMAM G4 dendrimer. In order to obtain water soluble conjugates the amine groups were substituted with R-glycidol. Material and methods. Polyamidoamine dendrimer of fourth generation was synthesized and examined by detailed NMR analysis in water and in DMSO. The conjugates were covalently linked to amine groups of PAMAM after activation of Fulvestrant 17-OH group with 4-nitrophenylchloroformate and activation of end-carboxyl group of Paclitaxel succinate. Results. The method of binary conjugate PAMAMG4-Fulvestrant-Paclitaxel synthesis was elaborated and the product was characterized by physicochemical methods. Conclusion. The glycidylated PAMAMG4-Fulvestrant-Paclitaxel conjugate is better soluble in water than unconverted drugs.
Źródło:
European Journal of Clinical and Experimental Medicine; 2023, 3; 442-449
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
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