- Tytuł:
- Bioactivation of chemicals by cytochromes P450
- Autorzy:
- Ioannides, C.
- Powiązania:
- https://bibliotekanauki.pl/articles/363274.pdf
- Data publikacji:
- 2007
- Wydawca:
- Uniwersytet Warmińsko-Mazurski w Olsztynie
- Tematy:
-
cytochrom P450
ksenobiotyk
kancerogeneza
aktywacja metaboliczna
cytochrome P450
xenobiotics
carcinogenesis
metabolic activation - Opis:
- Most chemical carcinogens require metabolism to generate highly reactive intermediates that manifest their carcinogenicity following covalent interaction with DNA. This bioactivation process is catalysed chiefly by cytochromes P450, a superfamily of enzymes localised primarily in the liver. The carcinogenic activity of a chemical is largely dependent on the profile and concentration of cytochromes P450 at the time of exposure.
- Źródło:
-
Environmental Biotechnology; 2007, 3, 1; 1-9
1734-4964 - Pojawia się w:
- Environmental Biotechnology
- Dostawca treści:
- Biblioteka Nauki
Artykuł