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Tytuł:
The influence of modification of metallic medical implants coated multi-doped carbon layers (DLC, DLC-Si and DLC–Si/Ag) on changes on the implants surface as a result of implant - bone contact considering orthopedic screws
Autorzy:
Świątek, L.
Grabarczyk, J.
Powiązania:
https://bibliotekanauki.pl/articles/284484.pdf
Data publikacji:
2016
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
implants
metallic implants
biological properties
Źródło:
Engineering of Biomaterials; 2016, 19, 138; 36
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Adhesion and growth of human osteoblast-like MG 63 cells on titanium and stainless steel samples developed for constructing bone implants
Autorzy:
Stranavova, L.
Bacakova, M.
Bacakova, L.
Fencl, J.
Powiązania:
https://bibliotekanauki.pl/articles/284428.pdf
Data publikacji:
2011
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
osteoblasts
biomaterials
implants
Opis:
Titanium and stainless steel are strong, corrosion - resistant and biocompatible metals. Thanks to their remarkable properties, they have been in use for a long time in clinical medicine, mainly for constructing and replacing large joints, in particular the bone-anchoring parts, e.g. cups and stems, and also for fabricating orthopaedic screws and splints. In the Czech Republic, these devices are produced by Beznoska Ltd., and are clinically applied in the Orthopaedic Clinic, Bulovka Faculty Hospital in Prague. This study has investigated the biocompatibility of samples made of pure titanium (according to quality standard ISO 5832-2 ) and corrosion-resistant steel (quality standards ISO 5832-1 and AISI 316L), obtained from Beznoska. In addition to Fe, the steel samples contained C (max. 0.025 wt. %), Si (0.6 wt. %), Mn (1.7 wt. %), P( max. 0.025 wt. %), S(max. 0.003 wt. %), Cr (17.5 wt. %), Ni (13.5 wt. %), Mo (2.8 wt. %), and Cu (max. 0.1 wt. %). The materials were used in the form of square samples (9x9 mm or 30x30 mm, thickness 1 mm ). Both Ti and steel samples were grinded with SiO2. The surface of the steel samples was then treated by polishing with Al2O3 paste (grain size up to 1 μm), while the surface of the Ti samples, i.e. a material not suitable for polishing, was finished by brushing using another type of Al2O3 paste with slightly larger grains. Thus, the surface of the steel samples was finally smoother and glossy, while the Ti surface was rougher and matted. For the in vitro biocompatibility tests, human osteoblast-like MG 63 cells (European Collection of Cell Cultures, Salisbury, UK) were used. The smaller samples (9 x 9 mm) were inserted into polystyrene 2 4-well cell culture plates (TPP, Trasadingen, Switzerland; well diameter 1.5 cm). Each well contained 25000 cells (approx. 14150 cells / cm 2 ) and 1.5 ml of Dulbecco’s Modified Eagle Minimum Essential Medium (DMEM; Sigma, USA, Cat. No. 10270-106) supplemented with 10 % foetal bovine serum (FBS; Gibco, Cat. No. 10270-106) and gentamicin (40 μg/ml, LEK, Slovenia). These samples were used for evaluating the size of the cell spreading area (day 1), and for evaluating cell shape and cell viability (days 1, 4 and 7 after seeding). The size o f the cell spreading area was measured using Atlas Software (Tescan Ltd., Brno, Czech Republic). The viability of the cells was determined by the LIVE/DEAD viability cytotoxicity kit for mammalian cells (Invitrogen, Molecular Probes, USA). The larger samples (30x30 mm) were inserted into GAMA polystyrene dishes (diameter 5 cm; GAMA Group Joint- Stock Company, Ceske Budejovice, Czech Republic) and seeded with 300000 cells/dish (approx. 15300 cells/cm 2) suspended in 9 ml of the above mentioned culture medium. These samples were used for evaluating the cell number on days 1, 4 and 7 after seeding, using a Beckman Vi- CELL XR Cell Analyser automatic cell counter. The results indicated that the number of initially adhering cells on day 1 after seeding was significantly lower on the titanium (5320±390 cells/cm2) and on the stainless steel ( 4110±370 cells/cm 2) than on the control polystyrene culture dishes (7740±350 cells/cm2). However, on day 4 after seeding, the cell population density on both metallic materials studied here became significantly higher than on the control polystyrene dishes (75200±2 890 cells/cm2 on Ti and 90870 ±2350 cells/cm2 on steel vs. 56440±1180 cells/cm2 on polystrene). This suggests faster cell proliferation on both metallic materials than on polystyrene. At the same time, the cell number on the stainless steel samples was significantly higher than on the Ti samples. On day 7, the differences in number of adhered cells on both studied metals and on the control polystyrene substrate was on an average similar (from 328780±680 cells/cm2 to 362200 ±760 cells/cm2). The cell viability on all tested materials was almost 100 % in all culture intervals. The morphology of the cells on the studied materials was similar to the morphology of the adhered cells on the control polystyrene dishes, i.e. the cells were mostly flat and polygonal, and the size of their cell spreading areas w as similar on all tested materials. The cells were distributed homogeneously on the entire material surface, and on day 4 they started to form confluent cell layers (FIG. (1). It can be concluded that the tests of biocompatibility confirmed that the titanium and the stainless steel promoted the adhesion and growth of bone - derived cells, and thus these materials are promising for construction of bone implants and for their good integration with the surrounding bone tissue. Further studies on osteogenic cell differentiation, potential immune activation and the response of the bone cells to growth factors, including bone morphogenetic protein, are in progress.
Źródło:
Engineering of Biomaterials; 2011, 14, no. 109-111 spec. iss.; 10-11
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Surface modifications of clinically used metallic implants for enhancing their biocompatibility and bioactivity – a review
Autorzy:
Bacakova, L.
Liskova, J.
Stankova, L.
Kromka, A.
Powiązania:
https://bibliotekanauki.pl/articles/284504.pdf
Data publikacji:
2014
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
metallic implants
biocompatibility
bioactivity
Źródło:
Engineering of Biomaterials; 2014, 17, 125; 2-5
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Porous hybrid materials as potential drug delivery systems
Autorzy:
Pajchel, Ł.
Szulkowska, A.
Kolmas, J.
Powiązania:
https://bibliotekanauki.pl/articles/283765.pdf
Data publikacji:
2018
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
hybrid materials
drugs
composites
Źródło:
Engineering of Biomaterials; 2018, 21, 148; 43
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Modification of graphene oxide and reduced graphene oxide with inorganic nanoparticles
Autorzy:
Jagiełło, J.
Baran, M.
Lipińska, L.
Powiązania:
https://bibliotekanauki.pl/articles/284372.pdf
Data publikacji:
2018
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
graphene
oxide
nanoparticles
Źródło:
Engineering of Biomaterials; 2018, 21, 148; 50
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Siła wiązania układu metal-ceramika w zastosowaniach stomatologicznych
Shear bond strength of ceramic – metal system for the dental applications
Autorzy:
Lubas, M.
Jasiński, J.
Jeziorski, L.
Powiązania:
https://bibliotekanauki.pl/articles/285176.pdf
Data publikacji:
2009
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
układ metal-ceramika
stop kobaltowo-chromowy
zastosowania stomatologiczne
ceramic-metal system
cobalt-chromium alloy
dental applications
Opis:
W pracy przedstawiono wyniki badań stanu powierzchni próbek ze stopu kobaltowo-chromowego po przeprowadzanej obróbce mechanicznej z zastosowaniem różnych mediów piaskujących (mieszanina Al2O3+SiO2 oraz tradycyjnie stosowany piasek korundowy - Al2O3).Wpływ mechanicznej obróbki na jakość po-wierzchni, określono na podstawie badań topografii powierzchni próbek metalicznych z zastosowaniem mikroskopu sił atomowych AFM. Przeprowadzone badania pozwoliły określić podstawowe parametry chropowatości Ra i Rz. Ponadto określono wpływ medium piaskującego na trwałość połączenia uzyskanych próbek ceramiczno-metalowych, stosując mikroskopię świetlną, skaningową oraz próbę zginania dwupunktowego. Wyniki badań wytrzymałościowych wykazały większą wytrzymałość połączenia dla próbek piaskowanych mieszaniną Al2O3 i SiO2- σ2=54MPa (σ1=49MPa - próbki piaskowane Al2O3).
In this paper the influence of sanding material type used for sand blasting mechanical treatment of cobalt-chromium alloy for metal to porcelain shear bond strength was investigated. Corundum sand (Al203) and corundum (Al203)+silica (SiO2) mixture was used as a sand blasting process medium. Metallic elements surface topography after sand blasting process was determined using AFM microscopy. Basic roughness parameters, Ra and Rz were also investigated. Two specimens series were tested for a shear load on a universal testing machine using a 1mm/min crosshead speed. Each series single specimen was tested on a tirpoint bending machine for failure stress (MPa) de-termination and observed using SEM microscopy. Results showed higher metal to porcelain bond strength for samples that were sand blasted with corundum Al203+silica SiO2 mixture, σ2=54MPa, as compared with corundum sand blasted samples σ1=49MPa.
Źródło:
Engineering of Biomaterials; 2009, 12, no. 89-91; 119-122
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Wpływ warstw DLC i DLC-Si na zmiany zachodzące na powierzchni implantów podczas współpracy z kością
The influence of the DLC and DLC-Si coatings on the changes occurring on the implants surface during the implant-bone contact
Autorzy:
Świątek, L.
Olejnik, A.
Grabarczyk, J.
Powiązania:
https://bibliotekanauki.pl/articles/286121.pdf
Data publikacji:
2016
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
DLC
Si
implant
wkręty ortopedyczne
trybologia
RF PACVD
implants
orthopaedic screws
tribology
Opis:
Niniejsza praca została poświęcona badaniu wpływu modyfikacji implantów medycznych warstwami węglowymi (DLC) oraz węglowymi domieszkowanymi krzemem (DLC-Si) na zmiany zachodzące w wyniku współpracy implantu z kością. Warstwy węglowe zostały wytworzone modyfikowaną metodą chemicznego osadzania z fazy gazowej – RF PACVD. W celu przeprowadzenia badań zostały użyte dwa rodzaje podłoży – pierwszą grupę stanowiły płaskie próbki cylindryczne, natomiast drugą wkręty ortopedyczne. Wszystkie wykorzystane próbki zostały wytworzone ze stali AISI 316 LVM. Przygotowane próbki z warstwami węglowymi zostały przebadane pod względem charakteryzacji powierzchni. W celu sprawdzenia składu chemicznego oraz topografii powierzchni przeprowadzono analizy XPS oraz AFM. Warstwy węglowe zostały również przebadane pod kątem wybranych właściwości mechanicznych (twardość, moduł Younga, adhezja), a także właściwości trybologicznych (test ball-on disc). Niemodyfikowane oraz modyfikowane wkręty ortopedyczne zostały poddane próbom wkręcania w kość wołową. Przeprowadzono testy wkręcania oraz wykręcania wkrętów w kość (w liczbie 1, 10, 50 oraz 100 cykli). Celem badań było określenie zmian zachodzących na powierzchni implantów w momencie ich współpracy z kością. Próbki po przeprowadzonych testach zostały poddane obserwacji mikroskopowej (SEM) oraz analizie jakościowej składu chemicznego na powierzchni wkrętów (EDS). Obserwacje mikroskopowe pozwoliły zaobserwować, iż do powierzchni modyfikowanych wkrętów ortopedycznych adherują elementy kości, tworząc silnie związany z powierzchnią tribofilm, co nie występuje w przypadku wkrętów niemodyfikowanych. Analiza EDS pozwoliła na potwierdzenie, iż w składzie chemicznym tribofilmu obecnego na implantach znajdują się mineralne składniki kości.
In this study the DLC and Si-incorporated DLC layers were deposited on stainless steel alloy (AISI 316 LVM) using modified radio frequency plasma assisted chemical vapour deposition (RF PACVD) method and examined in terms of chemical, mechanical and tribological properties. The carbon layers were synthesized on two types of samples: flat cylindrical probes and the orthopaedic screws (both were made from AISI 316 LVM). In order to determine the chemical composition, morphology and structure of the manufactured coatings the XPS, AFM, SEM observation and EDS analysis were performed. Mechanical properties were measured using nanoindentation technique, as well as the tribological properties were performed using ball-on-disc tests. The obtained results were correlated with the biological response of the coatings. The influence of changes of the modified implants surface was evaluated using screwing/unscrewing test. The samples after conducted tests were controlled using microscopic observation (SEM) and qualitative analysis of the chemical composition on the surface of the screws (EDS). Results demonstrate that on the surface of the DLC and DLC-Si coatings the tribofilm made from mineral bone compounds was created.
Źródło:
Engineering of Biomaterials; 2016, 19, 137; 2-12
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Potential activation of the immune system on metallic materials for bone implants
Autorzy:
Stranavova, L.
Bacakova, M.
Novotna, K.
Bacakova, L.
Fencl, J.
Powiązania:
https://bibliotekanauki.pl/articles/285314.pdf
Data publikacji:
2012
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
bone implants
metallic materials
biomaterials
Opis:
Titanium and stainless steel are metallic materials that have been in use for a long time in orthopedics, traumatology and stomatology. These metals are strong, corrosion-resistant and biocompatible. However, metallic materials have some disadvantages in comparison with the natural bone, particularly their relatively high specific weight and toughness. For example, the Young's modulus of AISI316L stainless steel, Co-Cr alloys and Ti-6Al-4V alloy, i.e. materials frequently used for implantation into bone, ranges between 110-220 GPa, while the Young's modulus of bone tissue is 10-40 GPa [1]. In addition, these metals can release cytotoxic, allergenic and immunogenic ions, which can affect their biocompatibility [2, 3]. Implantation is a special type of transplantation process, in which the implant is inserted into the body, usually in order to replace an irreversibly damaged tissue. However, the immune system recognizes the implant as a foreign substance and attacks it with its effector mechanisms. Just as it can reject other types of transplants, the immune system can reject an artificial implant. To prevent rejection of an implant, it is important to study the potential activation of the immune system. This study has investigated the biocompatibility of samples made of pure titanium (according to quality standard ISO 5832-2) and corrosion-resistant steel (quality standards ISO 5832-1 and AISI 316L), obtained from Beznoska Ltd. (Kladno, Czech Republic), and the potential activation of the immune system by these materials. In addition to Fe, the steel samples contained C (max. 0.025 wt.%), Si (0.6 wt.%), Mn (1.7 wt.%), P (max. 0.025wt.%), S (max. 0.003 wt.%), Cr (17.5 wt.%), Ni (13.5 wt.%), Mo (2.8 wt.%), and Cu (max. 0.1 wt. %). The materials were used in the form of square samples (9x9 mm or 30x30 mm, thick¬ness 1 mm). Both the Ti samples and the steel samples were ground with SiO2. The surface of the steel samples was then treated by polishing with Al2O3 paste (grain size up to 1 um), while the surface of the Ti samples, i.e. a material not suitable for polishing, was finished by brushing using another type of Al2O3 paste with slightly larger grains. Thus, the surface of the steel samples was finally smoother and glossy, while the Ti surface was rougher and matte. For the in vitro biocompatibility tests, human osteoblast-like MG 63 cells (European Collection of Cell Cultures, Salisbury, UK) were used. The smaller samples (9x9 mm) were inserted into polystyrene 24-well cell culture plates (TPP, Trasadingen, Switzerland; well diameter 1.5 cm). Each well contained 25 000 cells (approx. 14 150 cells/cm2) and 1.5 ml of Dulbecco's Modified Eagle Minimum Essential Medium (DMEM; Sigma, USA, Cat. No. 10270-106) supplemented with 10% foetal bovine serum (FBS; Gibco, Cat. No. 10270-106) and gentamicin (40 /jg/ml, LEK, Slovenia). These samples were used for evaluating the size of the cell spreading area (day 1), and for evaluating cell shape and cell viability (days 1, 4 and 7 after seeding). The size of the cell spreading area was measured using Atlas Software (Tescan Ltd., Brno, Czech Republic). The viability of the cells was determined by the LIVE/ DEAD viability/cytotoxicity kit for mammalian cells (Invitrogen, Molecular Probes, USA). The larger samples (30x30 mm) were inserted into GAMA polystyrene dishes (diameter 5 cm; GAMA Group Joint-Stock Company, Ceske Budejovice, Czech Republic) and seeded with 300 000 cells/dish (approx. 15 300 cells/cm2) suspended in 9 ml of the above mentioned culture medium. These samples were used for evaluating the cell number on days 1, 4 and 7 after seeding, using a Beckman Vi-CELL XR Cell Analyser automatic cell counter. For the in vitro analysis of markers of osteogenic differentiation and cell immune activation, human osteoblast-like MG 63 cells (European Collection of Cell Cultures, Salisbury, UK) were used. The samples (9x9 mm) were inserted into polystyrene 24-well cell culture plates (TPP, Trasadingen, Switzerland; well diameter 1.5 cm). Each well contained 25 000 cells (approx. 14 150 cells/cm2) and 1.5 ml of Dulbecco's Modified Eagle Minimum Essential Medium (DMEM; Sigma, USA, Cat. No. 10270-106) supplemented with 10% foetal bovine serum (FBS; Gibco, Cat. No. 10270-106) and gentamicin (40 jg/ml, LEK, Slovenia). The cells were cultured for 1, 4, or 7 days at 37°C in a humidified atmosphere of 5% of CO2 in the air. On day 4 after seeding, the medium was changed; one half of the samples contained standard medium DMEM with 10% foetal bovine serum and gentamicin (40 jg/ml) mentioned above, and the second half contained osteogenic medium, i.e. the standard medium further supplemented with ß-glycerophosphate, L-glutamin, ascorbic acid, dihydroxyvitamin D3, dexamethason, 10% foetal bovine serum and gentamicin (40 jg/ml). Using an Enzyme-Linked ImmunoSorbent Assay (ELISA), we measured the concentration of the Inter¬cellular Adhesion Molecule-1 (ICAM-1, a marker of cell immune activation) and osteocalcin (a marker of osteogenic cell differentiation). These measurements were performed in homogenates of cells on days 4 and 7 after seeding, and the concentration of both markers was measured per cell or per mg of protein. On day 7, the amount of osteocalcin was measured and compared in cells cultured in the standard and osteogenic media. We also measured TNF-а and IL- 1ß, i.e. other markers of cell immune activation. These cytokines are important mediators of the inflammatory response, and they are involved in a variety of cellular activities, including cell proliferation and differentiation. We measured the secretion of these markers into the cell culture medium in murine macrophage-like RAW264.7 cells (American Type Culture Collection, Manassas, VA). The samples (9x9 mm) were inserted into polystyrene 24-well cell culture plates (TPP, Tra- sadingen, Switzerland; well diameter 1.5 cm). Each well contained 30,000 (approx. 16 980 cells/cm2) cells and 1.5 ml of the culture medium. RAW 264.7 cells were cultured in the RPMI-1640 medium (Sigma; 10% fetal bovine serum, 40 jg/mL gentamicin). After 7 days of cultivation, the cell culture medium was collected and used for measuring the concentration of TNF-а and IL-1ß by a sandwich ELISA using commercially available kits. A mouse TNF-а kit and an IL- 1ß Quantikine ELISA kit were used for the RAW 264.7 cells. Both kits were purchased from R and D Systems (Minneapolis, MN) and used according to the manufacturer's protocol. The results indicated that the number of initially adhering MG 63 cells on day 1 after seeding was significantly lower on the titanium (5320±390 cells/cm2) and on the stainless steel (4110±370 cells/cm2) than on the control polystyrene culture dishes (7740±350 cells/cm2). However, on day 4 after seeding, the cell population density on both metallic materials became significantly higher than on the control polystyrene dishes (75200±2890 cells/cm2 on Ti and 90 870±2350 cells/cm2 on steel vs. 56440±1180 cells/cm2 on polystyrene). This suggests faster cell proliferation on both metallic materials than on polystyrene. At the same time, the cell number on the stainless steel samples was significantly higher than on the Ti samples. On day 7, the differences in the number of adhered cells on the two metals and on the control polystyrene substrate was on an average similar (from 328780±680 cells/cm2 to 362200±760 cells/cm2). The cell viability on all tested materials was almost 100% in all culture intervals. The morphology of the cells adhered on the studied materials was similar to the morphology of the cells on the control polystyrene dishes, i.e. the cells were mostly flat and polygonal, and the size of their cell spreading areas was similar on all tested materials. The cells were distributed homogeneously on the entire material surface, and on day 4 they started to form confluent cell layers. On day 4, we measured the amount of ICAM-1 by the ELISA test. This immunoglobulin molecule is typically expressed on cells of the immune system, but it is also expressed on other cell types, including MG 63, during their immune activation, e.g. by an artificial growth support. In this case, ICAM-1 molecules on cells are bound byß2-integrin receptors on inflammatory cells (for a review, see [4]). Surprisingly, titanium seemed to be more immunogenic than stainless steel, which was indicated by a higher concentration of ICAM-1 per cell and mg of protein in cells on day 4 after seeding. However, on day 7, there was no difference between the concentrations of ICAM-1 per cell and mg of protein in cells on titanium and on stainless steel. The second molecule that we measured was osteocalcin, a calcium-binding extracellular matrix glycoprotein, an important marker of the bone formation process. The concentration of osteocalcin on day 4 in the standard culture medium was higher in MG 63 cells on the titanium and stainless steel than on the control polystyrene samples. This could be explained by the fact that the metals are harder than polystyrene. It is known that harder substrates promote osteogenic cell differentiation, while softer substrates direct the cell differentiation towards neural or muscle phenotype [5]. In addition, the osteogenic differentiation was further supported by the osteogenic medium, as indicated by a higher concentration of osteocalcin in cells grown in this medium compared to cells in the standard medium on day 7 after seeding. On day 7 after seeding murine macrophage-like RAW264.7 cells on the tested materials, the concentration of TNF-а in the culture medium ranged on an average from 57.10 to 79.39 pg per 2000000 cells. The concentration of TNF-а in the medium from Ti and Fe was significantly higher than in the medium from the control polystyrene dishes. The highest value (79.39 pg/2000000 cells) was found in the medium taken from RAW264.7 cells on Ti. The second molecule that we tested was IL-1ß. No significant differences in the concentration of IL-1ß were detected in the culture medium obtained from RAW264.7 cells on all tested materials. In other words, neither type of metallic material, i.e. Ti and Fe, evoked significantly higher production of IL-1ß by RAW 264.7 cells than standard polystyrene cell culture dishes. It can be concluded that the tests of biocompatibility and immune activation confirmed that titanium and stainless are promising for construction of bone implants and for good integration with the surrounding bone tissue.
Źródło:
Engineering of Biomaterials; 2012, 15, no. 116-117 spec. iss.; 130-131
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Improved adhesion and growth of vascular smooth muscle cells on polycaprolactone nanofibrous membranes modified by amine-rich plasma
Autorzy:
Parizek, M.
Blahova, L.
Michlicek, M.
Medalova, J.
Cernochova, P.
Bacakova, L.
Zajickova, L.
Powiązania:
https://bibliotekanauki.pl/articles/970894.pdf
Data publikacji:
2018
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
muscle cells
nanofibrous membranes
polymers
Źródło:
Engineering of Biomaterials; 2018, 21, 148; 117
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Ocena przydatności materiałów polimerowych na implanty kręgosłupowe na podstawie badań post mortem na kozach
Evaluation of the usefulness of polymeric materiale for spinal implants on the basis of post mortem studies on goats
Autorzy:
Ciupik, L. F.
Kierzkowska, A.
Sterna, J.
Powiązania:
https://bibliotekanauki.pl/articles/284682.pdf
Data publikacji:
2010
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
polimer
badania na zwierzętach
biozgodność
implant kręgosłupowy
polymer
animal studies
biocompatibility
spinal implants
Źródło:
Engineering of Biomaterials; 2010, 13, 93; 10-13
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Adhesion, growth and osteogenic differentiation of human bone marrow mesenchymal stem cells on positively and negatively charged ferroelectric crystal surfaces
Autorzy:
Bacakova, L.
Vandrovcova, M.
Vanek, P.
Petzelt, J.
Powiązania:
https://bibliotekanauki.pl/articles/284786.pdf
Data publikacji:
2016
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
biomaterials
mesenchymal stem cells
crystal surfaces
Źródło:
Engineering of Biomaterials; 2016, 19, 138; 28
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Nano-sized micelles formed by self-assembling of polylactide(ethylene glycol) block copolymers in aqueous solutions
Autorzy:
Yang, L.
Zhao, Z.
Wei, J.
Li, S.
Powiązania:
https://bibliotekanauki.pl/articles/284952.pdf
Data publikacji:
2007
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
kopolimery
copolymers
Źródło:
Engineering of Biomaterials; 2007, 10, no. 63-64; 16-18
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Fullerene-titanium (C60/Ti) composites cause no DNA damage response in human osteoblast-like MG 63 cells
Autorzy:
Kopova, I.
Bacakova, L.
Vacik, J.
Lavrentiev, V.
Powiązania:
https://bibliotekanauki.pl/articles/284970.pdf
Data publikacji:
2010
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
fullerenes
composites
human osteoblasts
Opis:
Fullerenes (C60) and fullerene-based composites are considered as promising substrates for biological cell colonization. It might be mainly due to their nanostructure, resembling the nanoarchitecture of the natural extracellular matrix. Thin films of binary C60/Ti composites with various concentrations of Ti ranging from 25% (i.e., 25 Ti atoms and 75 C60 molecules) to 70% were deposited on microscopic glass coverslips in micro-patterned form through a metallic mask, and were tested for their potential use in bone tissue engineering. It is known that fullerenes and their derivatives can cause cytotoxic injury, cell death or inhibition of cell growth. These effects are based mainly on the reactivity of fullerenes, which may weaken with time due to the oxidization and polymerization of fullerenes in an air atmosphere. We therefore tested the dependence between the age of C60/Ti composites (i.e., from one week to one year) and the level of DNA damage of human osteoblast-like MG 63 cells in cultures on these materials. The DNA damage was analyzed by immunofluorescence staining of markers of DNA damage response, such as phosphorylation of histone H2AX and focal recruitment of p53-binding protein. As positive control to markers of DNA damage response was used 7 days long treatment with 2,5 mM Thymidine. We also monitored the proliferation and morphological changes of the cells. After 7 days of cultivation, we observe no cytotoxic morphological changes, such as enlarged cells or cytosolic vacuole formation, which are signs of cell senescence, and no increased induction of cell death. In addition, there was no increased level of DNA damage response on the C60/Ti composites (FIG.1). We also found no significant differences in cell population densities and no increased level of DNA damage among various Ti concentrations (FIG.1). Moreover, there was no effect of the age of the C60/Ti composites on the cell population densities or on the DNA damage response (FIG.1). These results suggest that fullerenes in combination with Ti do not cause cytotoxic injury and this material could be used in bone tissue engineering.
Źródło:
Engineering of Biomaterials; 2010, 13, no. 99-101; 109-110
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Nowe bioszkła zawierające srebro
New silver-containing bioglasses
Autorzy:
Ciołek, L.
Karaś, J.
Olszyna, A.
Traczyk, S.
Powiązania:
https://bibliotekanauki.pl/articles/285522.pdf
Data publikacji:
2008
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
bioszkło
nanoproszki
srebro
bioglasses
nanopowders
silver
Źródło:
Engineering of Biomaterials; 2008, 11, no. 77-80; 25-27
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Applications of flake graphene in tissue engineering
Autorzy:
Lipińska, L.
Jagiełło, J.
Baran, M.
Kurp, K.
Powiązania:
https://bibliotekanauki.pl/articles/285746.pdf
Data publikacji:
2018
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
graphene
tissue engineering
oxide
Źródło:
Engineering of Biomaterials; 2018, 21, 148; 51
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
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