- Tytuł:
- Manufacturing and characterization of resorbable PLGA membranes for biomedical applications
- Autorzy:
-
Krok, M.
Ferreira, C.
Fernandes, S.
Kościelniak, D.
Dobrzyński, P.
Pamuła, E. - Powiązania:
- https://bibliotekanauki.pl/articles/284710.pdf
- Data publikacji:
- 2011
- Wydawca:
- Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
- Tematy:
-
PLGA
PEG
porous membrane
phase-separation method
GTR - Opis:
- Porous poly(L-lactide-co-glycolide) (PLGA) membranes were prepared by solvent-casting/porogen leaching method. Poly(ethylene-glycol) (PEG) with two molecular weights was used as a pore former. Mechanical properties of the membranes were analyzed in tensile test. Topography, pore size and surface roughness were characterized by atomic force microscopy on both sites of the membranes. PEG leached out percentage, thickness and wettability were also measured. Osteoblast-like cells were cultured on the membranes for 24 h and 6 days, and morphology, distribution and number of adhered cells as well as secretion of proteins and nitric oxide were measured. The results show that PEG molecular weight affected size and distribution of pores on both surfaces of the membranes. It resulted also in different mechanical characteristics of the membranes. In vitro experiments show that the membranes support adhesion and growth of osteoblast-like cells suggesting their usefulness for guided tissue regeneration (GTR).
- Źródło:
-
Engineering of Biomaterials; 2011, 14, 104; 8-13
1429-7248 - Pojawia się w:
- Engineering of Biomaterials
- Dostawca treści:
- Biblioteka Nauki
Artykuł