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Wyszukujesz frazę "Piegat, A." wg kryterium: Wszystkie pola

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    Wyświetlanie 1-8 z 8
    Tytuł:
    Influence of surface (nano)roughness on cell behaviour
    Autorzy:
    Piegat, A.
    Fray, M. el
    Powiązania:
    https://bibliotekanauki.pl/articles/285111.pdf
    Data publikacji:
    2009
    Wydawca:
    Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
    Tematy:
    nanocomposites PVC / CNT
    AFM
    contact angle
    cell/tissue response
    Opis:
    The influence of surface (nano)roughness of soft elastomeric materials containing nanocrystalline TiO2 on tissue cell behaviour after implantation tests was investigated. Addition of small amount (0.2wt.%) of TiO2into polymer matrix changed surface roughness giving material of well developed lamellar morphology and slightly diminished contact angle (wettability). This lamellar (fibrilar) morphology had strong influence on cell response after implantation into soft tissue indi-cating the absence of eosynophiles in tissue around implant.
    Źródło:
    Engineering of Biomaterials; 2009, 12, no. 89-91; 257-258
    1429-7248
    Pojawia się w:
    Engineering of Biomaterials
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Chitosan based drug delivery systems
    Autorzy:
    Piegat, A
    Goszczyńska, A.
    Niemczyk, A.
    Powiązania:
    https://bibliotekanauki.pl/articles/285591.pdf
    Data publikacji:
    2016
    Wydawca:
    Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
    Tematy:
    drugs
    polymeric materials
    chitosan
    Opis:
    One of the research area in which polymeric materials are intensively explored, deals with the controlled drug delivery systems (DDSs), allowing for drugs distribution directly to the desired site of biological activity. The morphology of polymeric colloidal drug carriers can be described as a construction of a core-shell type. Depending on the chemical or physical bonds providing stability of those systems and the type of interactions between the drug and the polymer, among polymeric DDSs the following morphological structures can be distinguished: micelles, dendrimers, liposomes, niosomes, polymerosomes and micro- and nanocapsules [1]. The main advantages of those systems are the preparation of particles with desired size (diameter from nano to micrometers) during their synthesis / formation and high specific surface area, which can be modified by the appropriate chemical composition of the surface improving the efficiency of a drug delivery. Chitosan is biopolymer derived from chitin, that is characterised by biodegradability, biocompatibility, mucoadhesion and antimicrobial activity [2,3]. Taking into account the overall advantages of this polymer and the possibility of modification due to the accessible functional groups i.e. hydroxyl and amine, chemically modified chitosan is one of the most promising biomaterials for DDS. In order to obtain micelle structures by selfassemby in aqueous environment several hydrophobically modified chitosan derivatives, such as – stearic acid-modified chitosan [4], palmitic anhydridemodified chitosan [5], linolenic acid-modified chitosan [6], have been synthesized. The micelles prepared by these derivatives in the aqueous medium contain internal hydrophobic moieties as drug reservoir and external hydrophilic chitosan chains as surrounding shell. The above mentioned micellar systems allow encapsulation of hydrophobic antitumor drugs e.g. doxorubicin or paclitaxel due to the compatibility between the hydrophobic core and hydrophobic drug affecting the drug loading and regulate drug release. Another important group of chitosan based micro- and nanoparticles are those dedicated for gastric infection treatment. The use of chitosan in this specific application is mainly related with the mucoadhesive properties of chitosan resulted from the electrostatic interactions between its positively charged free amine groups and the negatively charged gastric mucins at the acidic stomach pH. Several problems such as high solubility of chitosan under stomach acidic conditions, low retention time and difficulty in crossing the mucus barrier have been observed in those systems [7]. Therefore various crosslinking methods e.g. with glutaraldehyde [8], genipin [9] or sodium triphosphate pentabasic (TPP) solution [10] were investigated in order to minimize these problems. The nanotechnological production of the polymeric drug carriers, as well as the disadvantages of already developed chitosan based drug delivery systems induce the NANOENCAP project concept on the development and characterization of new dendrimeric micelles polymeric systems, with rigidly defined chemical structure, allowing the encapsulation of several drugs and their controlled release, and thus forming the so-called multidrug therapy systems. To provide the biocompatibility of new polymeric materials the monomer / reactant with proven biocompatibility or naturally occurring in the human body are chosen. According to the assumptions of the project the amphiphilic character of the proposed multi-functional polymeric drug delivery systems is going to enable the encapsulation of at least two drugs, matching latest trends in the research on DDS models in multi-therapy. As an exemplary multi-drug therapy in this project, the combine therapy of peptic ulcer disease was chosen. In this work we would like to present the short review of chitosan based drug delivery systems and the concept of the project as well as preliminary studies on new chitosan derivatives and the possibility of synthesis new micellar structures.
    Źródło:
    Engineering of Biomaterials; 2016, 19, 138; 27
    1429-7248
    Pojawia się w:
    Engineering of Biomaterials
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Synthesis and characterization of amphiphilic chitosan derivatives as nano/microstructures
    Autorzy:
    Goszczyńska, A.
    Niemczyk, A.
    Piegat, A.
    Powiązania:
    https://bibliotekanauki.pl/articles/284331.pdf
    Data publikacji:
    2016
    Wydawca:
    Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
    Tematy:
    microstructures
    chitosan
    drug delivery systems
    Źródło:
    Engineering of Biomaterials; 2016, 19, 138; 38
    1429-7248
    Pojawia się w:
    Engineering of Biomaterials
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Chemical purity of new segmented polyester biomaterials
    Autorzy:
    Piegat, A.
    Walenia, M.
    El Fray, M.
    Powiązania:
    https://bibliotekanauki.pl/articles/284826.pdf
    Data publikacji:
    2014
    Wydawca:
    Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
    Tematy:
    polyester
    biomaterials
    chemical purity
    Źródło:
    Engineering of Biomaterials; 2014, 17, no. 128-129; 83-85
    1429-7248
    Pojawia się w:
    Engineering of Biomaterials
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Composites of polyvinyl alcohol (PVA) hydrogel and calcium and magnesium phosphate formed by enzymatic functionalization
    Autorzy:
    Douglas, T. E. L.
    Piegat, A.
    Schaubroeck, D.
    El Fray, M.
    Dubruel, P.
    Powiązania:
    https://bibliotekanauki.pl/articles/285623.pdf
    Data publikacji:
    2012
    Wydawca:
    Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
    Tematy:
    hydrogel
    composite
    mineralization
    enzyme
    Opis:
    In this study, polyvinyl alcohol (PVA) hydrogels designed for osteochondral regeneration were mineralized with calcium phosphate (CaP) and magnesium phosphate (MgP) by incorporation of the enzyme alkaline phosphatase (ALP) and incubation in solutions of 0.1 M calcium or magnesium glycerophosphate (CaGP, MgGP). Hydrogels incubated in water served as controls. Dry mass percentage, i.e. the percentage consisting of polymer and mineral and not water, was markedly higher for samples incubated in CaGP and MgGP and decreased in the order: CaGP>MgGP>water. CaP and MgP formation was confirmed by FTIR. SEM revealed spherical deposits characteristic for apatite in samples incubated in CaGP and plate-like crystals of the magnesium phosphate bobierrite in samples incubated in MgGP, while samples incubated in water were devoid of deposits. Rheometric testing showed that storage modulus of hydrogels incubated in CaGP and MgGP was markedly higher and decreased in the order: CaGP>MgGP>water. The results prove the principle of enzymatic mineralization of PVA with CaP and MgP to improve their suitability for bone regeneration applications.
    Źródło:
    Engineering of Biomaterials; 2012, 15, no. 116-117 spec. iss.; 137-138
    1429-7248
    Pojawia się w:
    Engineering of Biomaterials
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Wettability of poly(ester-ether)s for tissue engineering
    Autorzy:
    Kozłowska, A.
    Piegat, A.
    Fray, M. el
    Kubies, D.
    Chanova, E.
    Pop-Georgievski, O.
    Rypacek, F.
    Powiązania:
    https://bibliotekanauki.pl/articles/283903.pdf
    Data publikacji:
    2010
    Wydawca:
    Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
    Tematy:
    tissue engineering
    wettability
    biomaterials
    Źródło:
    Engineering of Biomaterials; 2010, 13, 92; 5-7
    1429-7248
    Pojawia się w:
    Engineering of Biomaterials
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The biocompatibility in vitro study of an innovative elastomer for heart assist devices construction
    Autorzy:
    Kościelniak-Ziemniak, M.
    Wilczek, P.
    Kustosz, R.
    Gonsior, M.
    Błachowicz, A.
    El Fray, M.
    Piegat, A.
    Piątek-Hnat, M.
    Powiązania:
    https://bibliotekanauki.pl/articles/285117.pdf
    Data publikacji:
    2014
    Wydawca:
    Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
    Tematy:
    biocompatibility
    elastomers
    biomaterials
    Źródło:
    Engineering of Biomaterials; 2014, 17, no. 128-129; 112-113 [wklejka]
    1429-7248
    Pojawia się w:
    Engineering of Biomaterials
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Preparation of fibrin networks on polymers containing nano-filler
    Autorzy:
    Kozłowska, A.
    Piegat, A.
    Skrobot, J.
    Strzałkowska, D.
    Fray, M. el
    Kubies, D.
    Riedel, T.
    Pop-Georgievski, O.
    Rypacek, F.
    Powiązania:
    https://bibliotekanauki.pl/articles/286247.pdf
    Data publikacji:
    2010
    Wydawca:
    Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
    Tematy:
    biomaterial surface
    polymers
    fibrin networks
    Źródło:
    Engineering of Biomaterials; 2010, 13, 92; 8-10
    1429-7248
    Pojawia się w:
    Engineering of Biomaterials
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-8 z 8

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