- Tytuł:
- Numerical experiments with model equations of cancer invasion of tissue
- Autorzy:
-
Kolev, M.
Zubik-Kowal, B. - Powiązania:
- https://bibliotekanauki.pl/articles/206179.pdf
- Data publikacji:
- 2011
- Wydawca:
- Polska Akademia Nauk. Instytut Badań Systemowych PAN
- Tematy:
-
in vivo tumorigenicity
cancer cells
proliferation
chemotaxis
haptotaxis
extracellular matrix
tumour invasion
mathematical model
animal models
approximations - Opis:
- In this paper we investigate a mathematical model of cancer invasion of tissue, which incorporates haptotaxis, chemotaxis, proliferation and degradation rates for cancer cells and the extracellular matrix, kinetics of urokinase receptor, and urokinase plasminogen activator cycle. We solve the model using spectrally accurate approximations and compare its numerical solutions with laboratory data. The spectral accuracy allows to use low-dimensional matrices and vectors, which speeds up the computations of the numerical solutions and thus to estimate the parameter values for the model equations. Our numerical results demonstrate correlations between numerical data computed from the mathematical model and in vivo tumour growth rates from prostate cell lines.
- Źródło:
-
Control and Cybernetics; 2011, 40, 3; 779-791
0324-8569 - Pojawia się w:
- Control and Cybernetics
- Dostawca treści:
- Biblioteka Nauki
Artykuł