- Tytuł:
- T-cell proliferation on immunopathogenic mechanism of psoriasis: a control based theoretical approach
- Autorzy:
-
Datta, A.
Roy, P. K. - Powiązania:
- https://bibliotekanauki.pl/articles/205612.pdf
- Data publikacji:
- 2013
- Wydawca:
- Polska Akademia Nauk. Instytut Badań Systemowych PAN
- Tematy:
-
T-cells
dendritic cells
keratinocytes
dermis
epidermis
cytokines
T-cell proliferation
drug efficacy
optimal control - Opis:
- Psoriasis vulgaris is a common, worldwide autoimmune skin disorder characterized by T-cells mediated hyperproliferation of keratinocytes. The feature of T-cells arbitrated psoriatic lesions is the epidermal infiltration of oligoclonal CD8+ T-cells and also of CD4+ T-cells in the dermis. Psoriatic scratches are identified by red and enlarged lesions along with silver whitish scales. In this article, we propose a mathematical model for psoriasis, involving a set of differential equations, concerning T-cells, dendritic cells and epidermal keratinocytes. We introduce T-cell proliferation in the system, where T-cells are generated through expansion of accessible CD4+ T-cells from precursors. We are interested in observing how the cell biological system develops through T-cell proliferation in presence of control with respect to T-cells and keratinocytes. We study the model in both implicit and explicit ways and measure the effect of drug on the system through impulsive drug therapy.
- Źródło:
-
Control and Cybernetics; 2013, 42, 2; 365-386
0324-8569 - Pojawia się w:
- Control and Cybernetics
- Dostawca treści:
- Biblioteka Nauki
Artykuł