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    Wyświetlanie 1-5 z 5
    Tytuł:
    Heater dedicated for Lab-on-a-chip systems
    Autorzy:
    Maciejewska, K.
    Jastrzebska, E.
    Dybko, A.
    Powiązania:
    https://bibliotekanauki.pl/articles/115423.pdf
    Data publikacji:
    2014
    Wydawca:
    Fundacja na Rzecz Młodych Naukowców
    Tematy:
    heater
    microsystem
    Lab-on-a-chip
    PTC
    grzejnik
    mikrosystem
    Opis:
    The authors report a new construction of a heater, which can be applied in Lab-on-a-chip systems. The heater was fabricated on a ceramic plate as a solid support. A commercially available paste DuPont 5091D with positive temperature coefficient (PTC) was used as a resistive material. Next, metallic conductors were created using gold sputtering in argon enhanced plasma environment. Finally, the gold layers were bonded with connection wires. The developed heater can be integrated with microsystems dedicated for bioanalysis, enzymatic reactions and cell cultures.
    Źródło:
    Challenges of Modern Technology; 2014, 5, 2; 15-18
    2082-2863
    2353-4419
    Pojawia się w:
    Challenges of Modern Technology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    ‘Lab-on-a-chip’ for cell engineering: towards cellular models mimicking in vivo
    Autorzy:
    Ziółkowska, K.
    Chudy, M.
    Dybko, A.
    Brzózka, Z.
    Powiązania:
    https://bibliotekanauki.pl/articles/115885.pdf
    Data publikacji:
    2011
    Wydawca:
    Fundacja na Rzecz Młodych Naukowców
    Tematy:
    Lab-on-a-chip
    microfluidic tools
    cancer
    cell culture
    Multicellular Tumor Spheroid (MCTS)
    Opis:
    One of the main scopes of modern cell engineering is development of cellular models that can replace animals in drug screening and toxicological tests, so called alternative methods. Construction of the alternative model is a very challenging task due to a richness of factors creating the in vivo environment. The monolayer cell culture — cultivation of adhesive cells on artificial surfaces such as glass or polymer — lack most of the in vivo-like interactions, but still is the only tool for the majority of applications. One of the most prospective approaches on mimicking in vivo environment is “Lab-on-a-chip” technology. Microfluidic devices offer lots of advantages over traditional in vitro culture, e.g. much higher cell volume-to-extracellular fluid volume ratio or possibility of regulation of hydrodynamic stress. This presentation aims to introduce latest advances of our team in microfluidic cell culture devices. Our novel approach is to cultivate three dimensional multicellular aggregates (spheroids) in microenvironments arranged in a microfluidic system. The geometry and materials of the system allow for cultivation, observation and analysis of multicellular spheroids. The results presented concern multicellular tumor spheroids (MCTS) rising from human cancer cells, which are considered to represent most of the conditionings of cancer tumor in vivo. The fully developed MCTS microdevice will be a reliable tool for anticancer drug screening, as the results most likely will be in a close accordance with the results obtained in vivo.
    Źródło:
    Challenges of Modern Technology; 2011, 2, 1; 79-82
    2082-2863
    2353-4419
    Pojawia się w:
    Challenges of Modern Technology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Novel designs and technologies for cell engineering
    Autorzy:
    Ziółkowska, K.
    Chudy, M.
    Dybko, A.
    Brzózka, Z.
    Powiązania:
    https://bibliotekanauki.pl/articles/115526.pdf
    Data publikacji:
    2011
    Wydawca:
    Fundacja na Rzecz Młodych Naukowców
    Tematy:
    lab-on-a-chip
    multicellular tumor spheroid
    cancer
    in vitro cell culture
    cell engineering
    Opis:
    Microfluidic devices, such as lab-on-a-chip systems, are highly advantageous for cell engineering and cell based assays. It is a particularly useful approach for development of the in vitro cellular systems mimicking the in vivo environment. In this paper, a novel lab-on-a-chip device for three-dimensional human cell culture and anticancer drug testing is presented. Cells were cultured as Multicellular Tumor Spheroids (MCTS) — the best cancer tumor model developed so far. Diff erent designs were tested and novel technique of microfabrication in poly(dimethylsiloxane) was developed. MCTS were cultured in a system of polymeric microwells, with the network of microfluidic channels for culture medium flow. Design included optimal shear stress and proper nutrients supply for cultured cells. Final design provided MCTS culture for four weeks with the homeostasis-like state achievement, which is characteristic for the in vivo situation.
    Źródło:
    Challenges of Modern Technology; 2011, 2, 4; 54-60
    2082-2863
    2353-4419
    Pojawia się w:
    Challenges of Modern Technology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    An integrated gas removing system for microfluidic application. Design and evaluation
    Autorzy:
    Hofman, I. M.
    Ziółkowska, K.
    Dybko, A.
    Brzózka, Z.
    Powiązania:
    https://bibliotekanauki.pl/articles/115931.pdf
    Data publikacji:
    2013
    Wydawca:
    Fundacja na Rzecz Młodych Naukowców
    Tematy:
    gas removing system
    debubbler
    debubbling system
    lab-on-a-chip
    microfluidics
    long-term cell culture
    cell spheroids
    HT-29 cells
    Opis:
    Microfluidic systems are used in a wide range of applications, including medical diagnostics, cell engineering and bioanalytics. In this work we focused on “Lab-on-a-chip” microsystems for cell cultivation. A troublesome problem of gas bubbles entering microdevices causing signal interferences and cells damage was emphasized. A novel, integrated debubbler in the form of cylindrical traps covered with thin PDMS membrane was designed and manufactured. Demonstrated debubbler was successfully applied in a long-lasting culture of HT-29 cell aggregates.
    Źródło:
    Challenges of Modern Technology; 2013, 4, 3; 10-15
    2082-2863
    2353-4419
    Pojawia się w:
    Challenges of Modern Technology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Development of a Point-of-Care system for early diagnostics of genetic diseases
    Autorzy:
    Kwapiszewski, R.
    Chudy, M.
    Dybko, A.
    Brzózka, Z.
    Powiązania:
    https://bibliotekanauki.pl/articles/115790.pdf
    Data publikacji:
    2012
    Wydawca:
    Fundacja na Rzecz Młodych Naukowców
    Tematy:
    lysosomal storage disorders
    Fabry disease
    Gaucher disease
    early diagnostics
    intracellular enzyme activity
    Point-of-Care system
    lab-on-a-chip system
    Opis:
    Lysosomal storage disorders (LSDs) represent a group of more than 45 genetically inherited diseases caused by the absence or deficiency of one or more specific lysosomal enzymes. Nowadays, there is a lack of reports on fast, reliable methods for the diagnostics of LSDs. Currently applied diagnostic approaches generate many false-negative and false-positive results, which results in classification of patients to inappropriate therapeutic groups. Moreover, these methods are time-consuming (even 20 hours), and are carried out only in a few laboratories in the world. The goal of this work was to develop a method and a tool, a Point-of-Care system, for diagnostics of LSDs. The polymeric microdevice consists of a cell lysis module, a mixing microchannel and an optical detection module. The system enables to determine the activity of α-galactosidase (deficient in Fabry disease), and to reduce the time of analysis to 10 min. Due to its easy fabrication steps and low price, it seems to be a prospective tool for a point-of-care approach.
    Źródło:
    Challenges of Modern Technology; 2012, 3, 2; 6-8
    2082-2863
    2353-4419
    Pojawia się w:
    Challenges of Modern Technology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-5 z 5

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