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Wyświetlanie 1-4 z 4
Tytuł:
Hydrogel coatings for artificial heart implants
Autorzy:
Trzaskowski, M.
Butruk, B.
Ciach, T.
Powiązania:
https://bibliotekanauki.pl/articles/115623.pdf
Data publikacji:
2011
Wydawca:
Fundacja na Rzecz Młodych Naukowców
Tematy:
polyurethane
polyvinylpyrrolidone
hydrogel coatings
artificial heart
Opis:
Polyurethanes (PU) are nowadays one of the most widely used types of polymers for biomedical applications. The segmented nature of these materials enables to obtain both flexibility and mechanical strength within the same material. However, there is a need to modify a surface of PU in order to produce highly hemocompatible materials that can be used in fabrication of permanent blood-contacting devices such as vascular implants, valves or hearts. Among many types of modifications, hydrogel coating appears to be very promising. Such modification increases the hydrophilicity of PU which in turn causes an increase in the bio- and hemocompatibility of the material. The aim of presented study was to create a polyvinylpyrrolidone (PVP) hydrogel coating onto a surface of polyurethane. A possibility of using a free radical polymerization reaction was investigated. The obtained materials were analyzed in terms of durability, swelling ratio and contact angle. The FTIR-ATR analysis confirmed that polyurethane surfaces have been successfully coated with PVP.
Źródło:
Challenges of Modern Technology; 2011, 2, 1; 19-22
2082-2863
2353-4419
Pojawia się w:
Challenges of Modern Technology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Electrospinning Production of PLLA Fibrous Scaffolds for Tissue Engineering
Autorzy:
Wojasiński, M.
Faliszewski, K.
Ciach, T.
Powiązania:
https://bibliotekanauki.pl/articles/115815.pdf
Data publikacji:
2013
Wydawca:
Fundacja na Rzecz Młodych Naukowców
Tematy:
nanofibre
electrospinning
poly(L-lactic acid)
tissue engineering
biomaterial
degradation
Opis:
Nonwoven fibrous mats were produced in the process of solution electrospinning. Polymeric fibres generated in this process consist of poly(L-lactic) acid (PLLA), biodegradable and biocompatible polymer. Produced fibrous mats were examined by scanning electron microscopy and additionally degradation rate of fibrous material was investigated. Obtained fibres exhibit porous surface and fibre diameter varied from 200 nm to 1,2 ım, depending on the process parameters. Low degradation rate of scaffold material was designed for long-term scaffold usage. The influence of solvent type and solution concentration as well as the solution flow rate, applied voltage and the setup geometry on the fibres morphology and diameter were examined and presented. The influence of polymer concentration on the solution viscosity was also evaluated. Further, the degradation rate of obtained fibres was investigated, as well as the influence of degradation process on surrounding environment. Materials produced in electrospinning process have potential application as long-term biodegradable scaffold for tissue engineering, especially in bone tissue, vascular tissue or cartilage tissue engineering.
Źródło:
Challenges of Modern Technology; 2013, 4, 1; 9-15
2082-2863
2353-4419
Pojawia się w:
Challenges of Modern Technology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Cell outer membrane mimetic surface as a material with improved hemocompatibility
Autorzy:
Trzaskowski, M.
Butruk, B.
Ciach, T.
Powiązania:
https://bibliotekanauki.pl/articles/115627.pdf
Data publikacji:
2011
Wydawca:
Fundacja na Rzecz Młodych Naukowców
Tematy:
phosphatidylcholine
polyurethane
cell outer membrane mimetic surface
artificial heart
Opis:
The phenomenon of blood coagulation on the surfaces of implantable devices such as artifi cial blood vessels, valves or hearts is the major problem that has to be taken into consideration during the construction of such devices. Since the main factor that has an infl uence on clotting of blood is the surface of the material the device is made of, numerous attempts has already been undertaken to modify surfaces of existing materials in order to provide necessary protection against clot formation, very often by coating the materials with bio-active substances. The aim of presented study was to create a coating of phosphatidylcholine that would mimic natural cell outer membrane on the surface of polyurethane — a material already in use in construction of cardiovascular implants. The obtained coated materials have been evaluated with the use of FT-IR/ATR spectroscopy. The change in contact angle of modifi ed material was also investigated. Finally in vitro cytotoxicity tests were performed in order to examine biocompatibility of obtained material.
Źródło:
Challenges of Modern Technology; 2011, 2, 4; 7-10
2082-2863
2353-4419
Pojawia się w:
Challenges of Modern Technology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Preparation of chitosan/calcium phosphate based injectable system for guided bone regeneration and its properties investigation
Autorzy:
Bubak, G.
Kowalczyk, M.
Brynk, T.
Bojar, W.
Kucharska, M.
Ciach, T.
Powiązania:
https://bibliotekanauki.pl/articles/115835.pdf
Data publikacji:
2011
Wydawca:
Fundacja na Rzecz Młodych Naukowców
Tematy:
chitosan
alginate
β-tricalcium phosphate
injectable systems
guided bone regeneration
in vivo studies
biomaterial
Opis:
The main objective of the work was to design and fabricate an injectable biomaterial with osteoconductive properties that can be used in dental applications in peri-implant therapy concerning guided bone regeneration. For that purpose, a self-setting biomaterial consisting of chitosan/tricalcium phosphate microparticles and sodium alginate was formulated. The obtained material was characterized regarding microsphere and formed agglomerates morphology and microstructure. Physical properties, relating to setting time and mechanical properties, were also investigated. Finally, in vivo response to implanted biomaterial was studied on a rat model and compared with commercially available alloplastic material. The results showed that designed injectable biomaterial fulfi lled main requirements for guided bone regeneration application.
Źródło:
Challenges of Modern Technology; 2011, 2, 4; 21-26
2082-2863
2353-4419
Pojawia się w:
Challenges of Modern Technology
Dostawca treści:
Biblioteka Nauki
Artykuł
    Wyświetlanie 1-4 z 4

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