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    Wyświetlanie 1-2 z 2
    Tytuł:
    Photocatalytic degradation of ampicillin using silver nanoparticles biosynthesised by Pleurotus ostreatus
    Autorzy:
    Jassal, P.S.
    Khajuria, R.
    Sharma, R.
    Debnath, P.
    Verma, S.
    Johnson, A.
    Kumar, S.
    Powiązania:
    https://bibliotekanauki.pl/articles/2096973.pdf
    Data publikacji:
    2020
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    ampicillin
    FTIR
    photocatalysis
    silver nanoparticles (Ag-NPs)
    TEM
    Opis:
    The past few decades have witnessed a tremendous increase in the consumption of antibiotics worldwide. This rampant and unregulated use of antibiotics and their improper disposal has led to the accumulation of these drugs in the environment. This in turn has led to the emergence of antibiotic resistance in microbes and has become one of the most pressing global concerns in medicine, with highly resistant pathogens of many species proving difficult to treat. The aim of the study was to synthesise silver nanoparticles (Ag-NPs) using white rot fungus, Pleurotus ostreatus and assess its potential to carry out photocatalytic degradation of ampicillin. UV–Vis spectroscopy, Fourier transform infrared spectroscopy and transmission electron microscope have been used to characterize biosynthesized Ag-NPs. The photocatalytic degradation of ampicillin in aqueous solution by Ag-NPs was evaluated under natural sunlight. The effect of the operating conditions (contact time, Ag-NP concentration and initial ampicillin concentration) on the photocatalytic degradation was also investigated. The highest ampicillin degradation of 96.5% was observed after exposure of the solution (antibiotic + nanoparticles) for 4 h in sunlight. The maximum degradation was observed at an Ag-NP concentration of 5 ppm at pH 6. To the best of our knowledge, photocatalytic degradation of ampicillin using Ag-NPs synthesised by P. ostreatus has not been reported earlier.
    Źródło:
    BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2020, 101, 1; 5-14
    0860-7796
    Pojawia się w:
    BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Drummondin E and Flinderole B are potential inhibitors of RNA-dependent RNA polymerase of SARS-CoV-2: an in silico study
    Autorzy:
    Akhtar, N.
    Verma, H.
    Silkari, O.M.
    Upadhyay, A.K.
    Kaushik, V.
    Mannan, M.A.
    Powiązania:
    https://bibliotekanauki.pl/articles/2096249.pdf
    Data publikacji:
    2022
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    RNA polymerase
    SARS-CoV-2
    RNA-dependent
    Drummondin E
    Flinderole B
    Opis:
    Coronavirus disease 2019 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has affected 235.6 million people worldwide. In the present study, RNA-dependent RNA polymerase (RdRp) (PDB Id: 6M71) of SARS-CoV-2, an essential enzyme needed for subgenomic replication and amplification of RNA, was selected. Similar to other RdRps, it is a conserved protein and a popular target for antiviral drug therapy. Based on a computational approach, potential RdRp inhibitors were identified. The absorption, distribution, metabolism, excretion, and toxicity (ADMET) of selected molecules were determined using computation tools. The potential inhibitors were docked to the RdRp and later confirmed by Molecular Dynamics (MD) using the “Flare” module of Cresset software. Drummondin E and Flinderole B had higher drug similarity scores among the compounds selected in this study. Both these compounds are noncarcinogenic, nonirritant, nontumorigenic, and nonmutagenic. Molecular docking studies showed that both compounds can bind to RdRp. The best ligand interaction patterns were validated by MD using the “Flare” module. MD was performed for the period of 100 ns with the time step of 1 fs. The simulation results suggest that Thr-680, Arg-624, Lys-676, and Val-557 are key interacting partners in the Drummondin E-RdRp complex, while Asp-618, Asp-760, Asp-623, Arg-624, and Asp-761 are the interacting partners in the Flinderole B-RdRp complex. Based on the in silico drug-likeness score; ADMET properties; and molecular simulation result, we surmise that Flinderole B and Drummondin E could impede SARS-CoV-2 genome replication and transcription by targeting the RdRp protein.
    Źródło:
    BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2022, 103, 1; 53-70
    0860-7796
    Pojawia się w:
    BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-2 z 2

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