- Tytuł:
- Developmental abnormalities in chicken embryos after injection proteolysis inhibitors from Ascaris suum
- Autorzy:
- Blaszkowska, J
- Powiązania:
- https://bibliotekanauki.pl/articles/840466.pdf
- Data publikacji:
- 2002
- Wydawca:
- Polskie Towarzystwo Parazytologiczne
- Tematy:
-
Ascaris suum
teratogen
proteolysis inhibitor
developmental abnormality
inhibitor
chicken embryo
injection - Opis:
- It bas been found that trypsin and α-chymotrypsin inhibitors isolated from Ascaris suum act embryotoxically and teratogenically on White Leghorn clucken embryos. Mortatity rate for the chicken embryos on day 15 of incubation was 45.0 ± 3.5% after injection of trypsin inbibitor and 44.0 ± 3.5% after adminstration α-chymotrypsin inbibitor. Gross examination of surviving embryos and their dissection revealed pathological changes (abdominal dropsy, umbilical hernia, subcutaneous oedema, hemoperitoneum, hemopericardium), symptoms indicating retardation in growth (lack of down, retarded ossification of long bones, decreased mean body weight) as well as malformations (schistocelia, micrognathia, cyclopia, crossed beak, cranial deformities) after injection of inhibitors from Ascaris. The highest incidence of embryos with pathological changes and malformations was found after administralion of α-chymotrypsin inbibitor. The most commonly occurring abnormality was schistocelia (21.4 ± 3.88%). Growth malformations were not found in the control groups. The trypsin and α-chymotrypsin inhibitors present in Ascaris homogenate have a significant disturbing effect on the development of the chicken embryo.
- Źródło:
-
Annals of Parasitology; 2002, 48, 1
0043-5163 - Pojawia się w:
- Annals of Parasitology
- Dostawca treści:
- Biblioteka Nauki
Artykuł