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    Wyświetlanie 1-4 z 4
    Tytuł:
    Seeking genetic determinants of selected metabolic disorders in women aged 45–60
    Autorzy:
    Szkup, M.
    Brodowski, J.
    Jurczak, A.
    Stanisławska, M.
    Grochans, E.
    Powiązania:
    https://bibliotekanauki.pl/articles/2085996.pdf
    Data publikacji:
    2020
    Wydawca:
    Instytut Medycyny Wsi
    Tematy:
    Genes
    Metabolic Syndrome X
    PPAR gamma
    Opis:
    Introduction and objective. The biochemical and anthropometric consequences of metabolic disorders exert an enormous effect on the functioning of people worldwide. The aim of this study is to assess relationships between biochemical and anthropometric parameters associated with metabolic syndrome, and the presence of the PPAR-γ rs1801282, the FTO rs9939609, and the MC4R rs17782313 polymorphisms in women aged 45–60. Materials and method. The study included 425 women, aged 45–59 years, from the general population of the West Pomeranian Province in north-west Poland. The research procedure involved a structured interview, anthropometric and blood pressure measurements, biochemical analysis of serum, and genetic analysis. Results. The carriers of the A/A genotype of the FTO polymorphism had higher LDL levels than their counterparts with the T/T genotype (p=0.01). The carriers of the T/T genotype of the MC4R polymorphism had lower non-HDL levels than those with the C/C and C/T genotypes (p=0.019). Weight was related to the C/C and the C/G + G/G genotypes of the PPAR-γ gene polymorphism (p=0.046). The model of inheritance for the MC4R polymorphism had a significant effect on TG (p=0.039) and non-HDL (p=0.05) levels. Conclusions. The genotypes analyzed in the study had only a slight direct effect on the biochemical and anthropometric abnormalities typical of metabolic disorders. Nonetheless, the risk alleles (A allele of the FTO rs9939609 and the C allele of the MC4R rs17782313) were found to be related to lipid metabolism disorders in 45–60-year-old women.
    Źródło:
    Annals of Agricultural and Environmental Medicine; 2020, 27, 3; 407-412
    1232-1966
    Pojawia się w:
    Annals of Agricultural and Environmental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Anti-inflammatory effect on genes expression after four days of Qigong training in peripheral mononuclear blood cells in healthy women
    Autorzy:
    Półrola, P.
    Wilk-Frańczuk, M.
    Wilczyński, J.
    Nowak-Starz, G.
    Góral-Półrola, J.
    Chrusciński, G.
    Bonisławska, I.
    Pedrycz, A.
    Żychowska, M.
    Powiązania:
    https://bibliotekanauki.pl/articles/2081731.pdf
    Data publikacji:
    2018
    Wydawca:
    Instytut Medycyny Wsi
    Tematy:
    qigong
    genes expression
    heat shock protein
    inflammation
    Opis:
    Introduction. Some studies have shown the influence of Qigong on gene expression in different cells, but there is little data associated with the influence of this kind of therapy on genes expression in pheripheral monocellucar blood cells. Objective. The aim of this study was to evaluate changes in the expression of genes associated with cellular stress response in peripheral mononuclear blood cells (PMBC) in healthy women. Materials and method. The experiment took place at the Japanese Martial Arts Centre “DOJO” in Stara Wieś, Poland, conducted over the course of a 4-day qigong training session. To evaluate the genes effect of this training, blood samples were taken before and after the training period. This experiment involved 20 healthy women (aged 56.2±9.01, body height 164.8±6.5 and mass 65.5±8.2). To determine the expression of HSF-1, HSPA1A, NF-kB, IL10 and CCL2 mRNA, 3 ml of venous blood was collected. The blood samples were placed in tubes allowing for separation (BD Vacutainer CPTTM) before and after the 4 days of qigong training. Isolated PMBC were used to determine gene expression using real-time qRT-PCR (quantitative reverse transcription polymerase chain reaction). Results. Significant decreases in NF-kB and CCL2 mRNA and increases in IL10, HSF1 and HSPA1A m-RNA were detected after 4 days of qigong training. The obtained findings suggest that qigong caused a reduction in the inflammatory and intensified anti-inflammatory gene expression, as well as a higher expression of HSF-1 and HSPA1A. Conclusion. The adaptive response to qigong training was similar to the adaptive response to physical activity and was detected through gene expression in PMBC. Furthermore, this kind of training is especially indicated for women because of their higher susceptibility to psychosocial stress when compared to men.
    Źródło:
    Annals of Agricultural and Environmental Medicine; 2018, 25, 2; 329-333
    1232-1966
    Pojawia się w:
    Annals of Agricultural and Environmental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Differences in the expression of selected genes associated with cell stress response in a PTSD patient and in healthy individuals – a case study
    Autorzy:
    Rasmus, Anna
    Półrola, Paweł
    Góral-Półrola, Jolanta
    Żychowska, Małgorzata
    Mirski, Andrzej
    Knapik, Henryk
    Powiązania:
    https://bibliotekanauki.pl/articles/986669.pdf
    Data publikacji:
    2017
    Wydawca:
    Instytut Medycyny Wsi
    Tematy:
    cell stress
    ptsd patient
    expression of selected genes
    healthy individuals
    Opis:
    Objective. The aim of the study was determination of the level in expression genes associated with cell stress response in a patient with PTSD. Case study. A 57-year-old PTSD patient, A.P., was the subject of the study. Blood samples were taken from the ulnar vein to assess the relative expression of the tested genes in leukocytes via a quantitative reverse transcription polymerase chain reaction (qRT-PCR). Results. A considerably decreased level in the expression HSF-1, NF-kB, Hif-1 and IL6 m-RNA was observed in the patient when compared to the control group. A low expression in HSPA1A, HSPB1, IL10 and CRP m-RNA compared with the control group was also noted. Conclusion. It is possible that the lower level of transcriptional factors: HSF-1, NF-kB and Hif-1 as well as IL6 m-RNA may be associated with the effect of the PTSD patient’s treatment.
    Źródło:
    Annals of Agricultural and Environmental Medicine; 2017, 24, 2
    1232-1966
    Pojawia się w:
    Annals of Agricultural and Environmental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    An evaluation of the genetic conditioning of evoking pain
    Autorzy:
    Pacian, A.B.
    Kocki, J.
    Pacian, J.
    Kaczoruk, M.
    Bylina, M.
    Kaczor-Szkodny, P.
    Galińska, E.M.
    Kulik, T.
    Panasiuk, L.
    Powiązania:
    https://bibliotekanauki.pl/articles/2085535.pdf
    Data publikacji:
    2020
    Wydawca:
    Instytut Medycyny Wsi
    Tematy:
    genetics
    chronic pain
    genes expression
    DRD1 gene
    molecular research
    Opis:
    Introduction and objective. Pain is an integral element of the pathogenic process and sometimes determines its course. Disorders in pain sensation, as well as its lack, the pain threshold, and variability in sensation of the same pain stimuli as more or less intensive by different persons, may be genetically conditioned. The aim of the study is to examine genes in pathogenesis of chronic pain. Materials and method. The study was conducted in a specially selected group of 31 persons: study group – 20 patients with chronic pain, and control group – 11 healthy individuals who did not experience pain. The control group of 11 healthy persons, compared with the study group, was the catalyst for determining the relative quantification (RQ) of gene expression. Biological material in the form of venous blood was collected from the study participants into the tubes containing anticoagulant EDTA KE/2.7 ml (ethylenediaminetetraacetic acid), preventing extracorporeal blood clotting. Results. Analysis of expression of the examined genes showed over-expression of the DRD1 gene in patients experiencing chronic pain, which means that in these patients an increased number of dopamine D1 receptors encoded by this gene should be expected. The dopamine D1 receptor is a G-protein-coupled receptor which regulates (stimulates or inhibits) adenyl cyclase – the enzyme responsible for synthesis of cyclic AMP (cAMP). An increase in the concentration of cAMP in neurons enhances the sensation of pain. Conclusions. The genes (DRD1, COMT, OPRK1, HCN2) have a significant role in the pathogenesis of chronic pain in various diseases; they can also influence the perception of pain. Knowledge of these genes can contribute to the development of effective methods of combating pain.
    Źródło:
    Annals of Agricultural and Environmental Medicine; 2020, 27, 2; 274-278
    1232-1966
    Pojawia się w:
    Annals of Agricultural and Environmental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-4 z 4

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