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    Wyświetlanie 1-3 z 3
    Tytuł:
    Research on substances with activity against orthopoxviruses
    Autorzy:
    Kolodziej, M.
    Joniec, J.
    Bartoszcze, M.
    Gryko, R.
    Kocik, J.
    Knap, J.
    Powiązania:
    https://bibliotekanauki.pl/articles/51870.pdf
    Data publikacji:
    2013
    Wydawca:
    Instytut Medycyny Wsi
    Opis:
    Although smallpox was eradicated over 30 years ago, the disease remains a major threat. High mortality, high infectivity and low resistance of the contemporary population make the smallpox virus very attractive to terrorists. The possible presence of illegal stocks of the virus or risk of deliberate genetic modifications cause serious concerns among experts. Hence, it is reasonable to seek effective drugs that could be used in case of smallpox outbreak. This paper reviews studies on compounds with proven in vitro or in vivo antipoxviruses potential, which show various mechanisms of action. Nucleoside analogues, such as cidofovir, can inhibit virus replication. Cidofovir derivatives are developed to improve the bioavailability of the drug. Among the nucleoside analogues under current investigation are: ANO (adenozine N1-oxide) and its derivatives, N-methanocarbothymidine [(N)-MCT], or derivatitives of aciklovir, peninclovir and brivudin. Recently, ST-246 – which effectively inhibits infection by limiting release of progeny virions – has become an object of attention. It has been also been demonstrated that compounds such as: nigericin, aptamers and peptides may have antiviral potential. An interesting strategy to fight infections was presented in experiments aimed at defining the role of individual genes (E3L, K3L or C6L) in the pathogenesis, and looking for their potential blockers. Additionally, among substances considered to be effective in the treatment of smallpox cases, there are factors that can block viral inhibitors of the human complement system, epidermal growth factor inhibitors or immunomodulators. Further studies on compounds with activity against poxviruses are necessary in order to broaden the pool of available means that could be used in the case of a new outbreak of smallpox.
    Źródło:
    Annals of Agricultural and Environmental Medicine; 2013, 20, 1
    1232-1966
    Pojawia się w:
    Annals of Agricultural and Environmental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Analysis of a child infected with Hymenolepis diminuta in Poland
    Autorzy:
    Kolodziej, P.
    Rzymowska, J.
    Stepien-Rukasz, H.
    Lorencowicz, R.
    Lucinska, M.
    Dziobek, M.
    Powiązania:
    https://bibliotekanauki.pl/articles/50497.pdf
    Data publikacji:
    2014
    Wydawca:
    Instytut Medycyny Wsi
    Opis:
    Hymenolepis diminuta is a cosmopolitan parasite of rats and mice which is very rare in humans. This study presents the case of a 3-year-old boy infected with Hymenolepis diminuta in Poland. The diagnosis was based on eggs found and their morphology in the patient’s stool.
    Źródło:
    Annals of Agricultural and Environmental Medicine; 2014, 21, 3
    1232-1966
    Pojawia się w:
    Annals of Agricultural and Environmental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Prevalence of Borrelia burgdorferi in ticks removed from skin of people and circumstances of being bitten - research from the area of Poland, 2012–2014
    Autorzy:
    Gałęziowska, E.
    Rzymowska, J.
    Najda, N.
    Kołodziej, P.
    Domzal-Drzewicka, R.
    Rzaca, M.
    Muraczyńska, B.
    Charzyńska-Gula, M.
    Szadowska-Szlachetka, Z.
    Ślusarska, B.
    Guty, E.
    Powiązania:
    https://bibliotekanauki.pl/articles/2081592.pdf
    Data publikacji:
    2018
    Wydawca:
    Instytut Medycyny Wsi
    Tematy:
    ticks
    Borrelia burgdorferi
    tick- borne disease
    Lyme disease
    tick’s bite
    Opis:
    Introduction. During feeding, the tick sucks blood from the host along with the pathogens that are in the blood, simultaneously exchanging its own pathogens with the host. Humans can also be a host. It is important to understand the most typical circumstances in which people might become infected with Borrelia burgdorferi. This knowledge will help to prepare health education programmes aimed at the prevention of Lyme disease and other tick-borne diseases. Objective. The aim of the study was to determine the percentage of ticks infected with Borrelia burgdorferi sensu lato, depending on the circumstances of getting bitten. Materials and method. The research material consisted of ticks acquired from people who had been bitten, and questionnaires completed by these people. 510 ticks were acquired from 257 females and 253 males. Following delivery of a tick for testing, the stage of its development was determined and a molecular assay of Borrelia burgdorferi DNA performed. Results. A positive result of the nested-PCR test was obtained in 78 ticks, which represents 15.30% of all ticks. The infected ticks were collected from male (41 ticks – 52.56%) and female subjects (37 ticks – 47.44%). The biggest number of infected ticks were collected in autumn (54 ticks – 69.23%) and from people who had been into forests (44 ticks – 56.41%). Among the people from whom the infected ticks were acquired, the dominating group included persons over 16 years of age (53 persons – 67.95%) and children aged 0–5 years (16 persons – 20.51%). One in four infected ticks were acquired from the southwestern (20 ticks – 25.64%) and eastern regions of Poland (21 ticks – 26.92%). Conclusion. Infestation of ticks infected with Lyme disease spirochete in this study proved to be variable and depend on the season, the area of tick attack and the region in Poland. The results of the study clearly show that ticks infected with Borrelia burgdorferi inhabit all regions of Poland. The results are consistent with National Institute of Hygiene data which indicates that Lyme disease cases are recorded in all regions of Poland.
    Źródło:
    Annals of Agricultural and Environmental Medicine; 2018, 25, 1; 31-35
    1232-1966
    Pojawia się w:
    Annals of Agricultural and Environmental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-3 z 3

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