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Wyszukujesz frazę "Jabłoński, P." wg kryterium: Autor


Wyświetlanie 1-2 z 2
Tytuł:
Determining the scale of designer drugs (DD) abuse and risk to public health in Poland through an epidemiological study in adolescents
Autorzy:
Bilinski, P.
Kapka-Skrzypczak, L.
Jablonski, P.
Powiązania:
https://bibliotekanauki.pl/articles/51039.pdf
Data publikacji:
2012
Wydawca:
Instytut Medycyny Wsi
Opis:
Since 2008, it has been recognised by most health authorities worldwide that the abuse of newly-emerging psychoactive drugs, (‘designer drugs’/‘legal highs’; DD), in youth is a rapidly increasing problem, especially in the EU, threatening to offset gains made in tackling established and illegal drugs which they are intended to mimic; DD diversity is continually increasing to circumvent laws. The aim of the study was to determine the scale of DD abuse/availability amongst Polish youth. The surveyed test population was randomly selected from a representative group of adolescents attending high schools, secondary schools and universities throughout Poland. Questionnaires were completed by 14,511 subjects (10,083 school pupils and 4,428 students). Few persons from each group admitted using DDs; 453 schoolpupils (4.49%) vs. 81 students (1.83%). More males (4.74%) took DDs than females (2.77%). The tendency to take DDs in the company of friends was high in both DD-taking groups (>80%). DDs were consumed mostly in open spaces (34.15%), discos/pubs (21.13%) and boarding school/friend’s house (20.57). Most frequently, DDs came from shops (57.68%), friends (31.46%) or dealers (10.11%). Ensuing symptoms included; happy/euphoric mood (58.80%), talkativeness (42.51%) and hallucinations (22.85%). Over 74% of DDtakers in both groups experienced adverse reactions, and those requiring help sought it from: friends/colleagues (6.74%), doctors (5.06%), and hospitals (4.87%), but most rarely from parents/guardians (2.62%). Urgent action is being taken, especially in youth education, to prevent DDs becoming the serious menace seen with conventional drugs.
Źródło:
Annals of Agricultural and Environmental Medicine; 2012, 19, 3
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Anti-epileptic drugs inhibit viability of synoviocytes in vitro
Autorzy:
Parada-Turska, J.
Nowicka-Stazka, P.
Majdan, M.
Jablonski, M.
Turski, W.A.
Rzeski, W.
Powiązania:
https://bibliotekanauki.pl/articles/51168.pdf
Data publikacji:
2013
Wydawca:
Instytut Medycyny Wsi
Opis:
Introduction and objective: The hyperplasia of synovial fibroblasts is considered to be essential for the evolution of joint destruction in rheumatoid arthritis (RA). Previously, we reported that anti-rheumatic drugs, both COX inhibitors and disease-modifying anti-rheumatic drugs inhibit proliferation of synoviocytes in vitro. The presented study investigates the effect of anti-epileptic drugs on the viability and proliferation of synovial fibroblasts in vitro. Methods: Experiments were conducted on human synoviocytes derived from an RA patient and rabbit synoviocytes cell line HIG-82. Cell proliferation and viability were assessed by means of BrdU assay and MTT assay, respectively. The IC50 value (the concentration of drug necessary to induce 50% inhibition) together with confidence limits was calculated. Results: Carbamazepine inhibited proliferation of human fibroblasts and viability of HIG-82 with IC50 values of 86 μM and 82 μM, respectively. Diphenylhydantoin, valproate and phenobarbital inhibited viability of HIG-82 cells with the IC50 values of 110, 500 and 1031 μM, respectively. Conclusion: Based on these findings, it can be suggested that anti-epileptic drugs may have a disease-modifying effect on rheumatoid synovial proliferation.
Źródło:
Annals of Agricultural and Environmental Medicine; 2013, 20, 3
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
    Wyświetlanie 1-2 z 2

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