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    Wyświetlanie 1-2 z 2
    Tytuł:
    Psychological factors and genetic characteristics of rural cannabis users
    Autorzy:
    Lachowicz, M.
    Chmielowiec, J.
    Chmielowiec, K.
    Suchanecka, A.
    Michałowska-Sawczyn, M.
    Mierzecki, A.
    Mroczek, B.
    Grzywacz, A.
    Powiązania:
    https://bibliotekanauki.pl/articles/2085700.pdf
    Data publikacji:
    2020
    Wydawca:
    Instytut Medycyny Wsi
    Tematy:
    addiction
    polymorphism
    personality traits
    cannabis
    Opis:
    Introduction. Marijuana is one of the most widely used psychoactive substance. There is evidence of genetic predisposition for addiction. Objective. The aim of the study is to evaluate personality traits measured by the NEO Five-Factor Inventory and State-Trait Anxiety Inventory, combined with analysis of Tag1B rs1079597 and Tag1D rs1800498 located in the DRD2 gene. Materials and method. The study group consisted of 214 rural cannabinoid users and 301 controls. The same psychometric test and real-time PCR genotyping were performed in both studied groups. Results. The values of Anxiety state, Anxiety trait, NEO FFI: Neuroticism and Openness in the rural cannabis using group were significantly higher than in the control group. On the other hand, lower values were observed among rural people using cannabis compared to the control group for NEO FFI: Extraversion, Agreeability and Conscientiousness. In the Anxiety trait subscale, a 2% association with the polymorphism DRD2 Tag1B rs1079597 was detected in subjects using cannabis. However, for the DRD2 Tag1D rs1800498, there was no effect on the differences in personality traits between rural cannabis users and the control group. Conclusions. The study shows differences in personality traits between the cannabis using group and controls. Interaction between genetic factors and personality traits was also detected. The association showing the combination of psychological characteristics and genetic variants can bring us closer to the overall picture of the issue of marijuana addiction.
    Źródło:
    Annals of Agricultural and Environmental Medicine; 2020, 27, 2; 260-268
    1232-1966
    Pojawia się w:
    Annals of Agricultural and Environmental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Effect of menopausal hormone therapy on the levels of magnesium, zinc, lead and cadmium in post-menopausal women
    Autorzy:
    Jurczak, A.
    Brodowski, J.
    Grochans, E.
    Karakiewicz, B.
    Szkup-Jablonska, M.
    Wieder-Huszla, S.
    Mroczek, B.
    Wloszczak-Szubzda, A.
    Grzywacz, A.
    Powiązania:
    https://bibliotekanauki.pl/articles/50553.pdf
    Data publikacji:
    2013
    Wydawca:
    Instytut Medycyny Wsi
    Opis:
    Introduction and objective: The level of trace elements is extremely important for the maintenance of normal functioning of the human body. The risk of disturbance of their balance increases especially dynamically during the period of menopause. The objective of the study was the effect of MHT on the levels of bioelements (Mg and Zn) in blood plasma, and toxic metals (Pb and Cd) in the whole blood in postmenopausal women. Materials and methods: The study covered 323 women at postmenopausal age from the population of the West Pomeranian Region, in whom the levels of Mg, Zn, Pb and Cd were determined. The women were divided into two groups: study and control. The study group were 152 women who used menopausal hormone therapy (MHT). The control group were 171 women who did not use MHT, and had had their final menstrual period at least one year prior to inclusion in the study. The mean age of the women examined was 56±5. Results: Significantly higher levels of the bioelements Mg, Zn were observed in women who used MHT, compared to the control group (p<0.05). The concentration of Pb in whole blood was significantly lower in the study than the control group: 16.09±7.33 μg/l and 20.18±9.01 μg/l, respectively. An elevated level of Cd in whole blood was found in both groups of women: 0.9±1.03 μg/l and 0.8±1.1 μg/l, respectively. It was noted that women who used MHT more frequently declared the presence of climacteric symptoms (p<0.05). Conclusions: 1) Higher levels of Mg and Zn were found in blood plasma of women who used MHT. 2) The mean concentration of Cd in the blood of women in both groups was similar. 3) In women who use MHT the level of Pb in whole blood was lower, compared to the rest of the women.
    Źródło:
    Annals of Agricultural and Environmental Medicine; 2013, 20, 1
    1232-1966
    Pojawia się w:
    Annals of Agricultural and Environmental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-2 z 2

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