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Wyświetlanie 1-15 z 48
Tytuł:
Acute respiratory distress syndrome (ARDS) in the course of influenza A/H1N1v infection – genetic aspects
Autorzy:
Niemcewicz, M.
Pajak, B.
Michalski, A.
Kocik, J.
Kolodziej, M.
Joniec, J.
Graniak, G.
Gawel, J.
Marciniak-Niemcewicz, A.
Kucharczyk, K.
Prystupa, A.
Witczak, A.
Lasocki, K.
Naylor, K.
Goniewicz, M.
Powiązania:
https://bibliotekanauki.pl/articles/49651.pdf
Data publikacji:
2013
Wydawca:
Instytut Medycyny Wsi
Źródło:
Annals of Agricultural and Environmental Medicine; 2013, 20, 4
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Peroxiredoxin-1 as a prognostic factor in patients with ovarian cancer
Autorzy:
Sieńko, J.
Teliga-Czajkowska, J.
Przytula, E.
Czajkowski, K.
Smolarczyk, R.
Nowis, D.
Powiązania:
https://bibliotekanauki.pl/articles/2085041.pdf
Data publikacji:
2019
Wydawca:
Instytut Medycyny Wsi
Tematy:
Peroxiredoxin-1
PRDX-1
ovarian cancer
overall survival
disease free survival
Opis:
Introduction and objective. Peroxiredoxin-1 (PRDX-1) belongs to a family of antioxidant enzymes and has proved to be a versatile molecule regulating cell growth, differentiation and apoptosis. PRDX1-regulated signaling pathways play an important role in the progression and metastasis of human tumours, especially in breast, esophageal and lung cancers. The aim of the study was to evaluate the expression of PRDX-1 in ovarian cancer tissues, and to test the clinical value of PRDX-1 as a prognostic factor in this malignancy. Materials and method. PRDX-1 expression was assessed by automated immunohistochemistry in tumours taken from 55 patients with ovarian cancer during primary surgery. Specimen were formalin-fixed and preserved in paraffin-embedded blocks. The results were correlated with clinicopathological data. Results. A high expression of PRDX-1 was observed in 20% of cases, and was associated with worse compliance to chemotherapy protocol (P<0.002), worse response to chemotherapy (P<0.04), and higher levels of CA 125 after the 1st line treatment (P<0.004). PRDX-1 positive subjects had a significantly lower 5-year disease-free survival (9.1% vs. 42.6%, P<0.01) and a lower 5-year overall survival (9.1% vs. 56.7%; P<0.002). Multivariate analysis showed that a high expression of PRDX-1 is an independent prognostic factor of poor, overall survival (P<0.002) and a disease-free survival (P<0.01). Conclusion. Results of the study show that PRDX-1 expression in tumour tissues can be another biomarker of prognosis in patients with ovarian cancer.
Źródło:
Annals of Agricultural and Environmental Medicine; 2019, 26, 3; 415-419
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Gender and Age – Dependent effect of type 1 diabetes on obesity and altered body composition in young adults
Autorzy:
Szadkowska, A.
Madej, A.
Ziolkowska, K.
Szymanska, M.
Jeziorny, K.
Mianowska, B.
Pietrzak, I.
Powiązania:
https://bibliotekanauki.pl/articles/51380.pdf
Data publikacji:
2015
Wydawca:
Instytut Medycyny Wsi
Źródło:
Annals of Agricultural and Environmental Medicine; 2015, 22, 1
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The role of immune checkpoint inhibitors in prostate cancer
Autorzy:
Surdacki, G.
Szudy-Szczyrek, A.
Gorący, A.
Chyl-Surdacka, K.
Hus, M.
Powiązania:
https://bibliotekanauki.pl/articles/2082066.pdf
Data publikacji:
2018
Wydawca:
Instytut Medycyny Wsi
Tematy:
prostate cancer
checkpoint inhibitor
PD-1
PD-L1
CTLA-4
Opis:
Introduction. Prostate cancer (PC) is the most commonly diagnosed malignant tumour and the third cause of cancer deaths among men in Europe. The treatment of early-stage PC is very effective and in many cases allows achievement of a complete cure, whereas the treatment of metastatic prostate cancer (mPC) is still a huge challenge for clinicians. New therapeutic strategies for mPC are urgently needded. One of the most promising methods of treatment is anticancer immunotherapy including the monoclonal antibodies against immune checkpoint inhibitors. Objectives. To present the potential possibilities of using checkpoint inhibitors blockage in the treatment of mPC, and to overview the results of recent research on immune checkpoint inhibitors in patients with PC. State of knowledge. Recent studies suggest that monoclonal antibodies directed against immune checkpoint inhibitors in combination with traditional therapy may become a breakthrough in the treatment of mPC in the near future. Conclusions. The immunotherapy using monoclonal antibodies against immune checkpoint inhibitors seems to be a new opportunity for patients with advanced PC. The key to achieve the maximum anti-tumour response is to choose the best candidates for this therapy and determine the optimal sequence and combination of drugs. The introduction of immunotherapy as the standard treatment of patients with advanced PC requires further studies.
Źródło:
Annals of Agricultural and Environmental Medicine; 2019, 26, 1; 120-124
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Do inflammatory factors play a significant role in etiopathogenesis of endometrial cysts? Part 1
Autorzy:
Chmaj-Wierzchowska, K.
Kampioni, M.
Wilczak, M.
Opala, T.
Powiązania:
https://bibliotekanauki.pl/articles/49262.pdf
Data publikacji:
2013
Wydawca:
Instytut Medycyny Wsi
Źródło:
Annals of Agricultural and Environmental Medicine; 2013, 20, 4
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Managing water safety in healthcare. Part 1 – Strategies and approaches for waterborne pathogen control
Autorzy:
Bilinski, P.
Holownia, P.
Parafinska, K.
Tomaszewski, W.
Kapka-Skrzypczak, L.
Powiązania:
https://bibliotekanauki.pl/articles/50162.pdf
Data publikacji:
2012
Wydawca:
Instytut Medycyny Wsi
Opis:
Summaries in 2 parts are presented from a conference held in London at the Royal Society for Public Health on 16-17 May 2012, on the latest developments in dealing with waterborne hospital-acquired infections (nosocomial), from the UK perspective. Also included were some views from continental Europe. The first part, focuses on management strategies and plans that are either in use or recommended by domestic/international guidelines, such as the WHO, for prevention, control and risk assessment of disease outbreaks resulting from the presence of these pathogenic microorganisms in water appliances/supplies. Various solutions are discussed, some more effective than others, but all require a comprehensive strategy and technical expertise run by properly trained and dedicated professionals.
Źródło:
Annals of Agricultural and Environmental Medicine; 2012, 19, 3
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Chromium (III) and chromium (VI) as important players in the induction of genotoxicity – current view
Autorzy:
Sawicka, E.
Jurkowska, K.
Piwowar, A.
Powiązania:
https://bibliotekanauki.pl/articles/28762874.pdf
Data publikacji:
2021
Wydawca:
Instytut Medycyny Wsi
Źródło:
Annals of Agricultural and Environmental Medicine; 2021, 28, 1; 1-10
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Neuroprotective activity of 2-amino-1,3,4-thiadiazole derivative 4BrABT – an in vitro study
Autorzy:
Juszczak, M.
Walczak, K.
Langner, E.
Karpinska, M.
Matysiak, J.
Rzeski, W.
Powiązania:
https://bibliotekanauki.pl/articles/49999.pdf
Data publikacji:
2013
Wydawca:
Instytut Medycyny Wsi
Opis:
4BrABT (2-(4-Bromophenylamino)-5-(2,4-dihydroxyphenyl)-1,3,4-thiadiazole) is a compound known for its interesting in vitro anticancer profile. 4BrABT inhibited proliferation and motility of several cancer cell lines in concentrations which were not toxic to normal cells. A major problem associated with cancer chemotherapy, but also caused by environmental factors such as pesticides, is neurotoxicity. Therefore, the aim of the presented study was an in vitro evaluation of the neuroprotective activity of this compound. 4BrABT activity (1–100 μM) was tested in cultures of mouse neurons, rat astrocytes and rat oligodendrocytes. A possible protective action of the compound in different neurodegenerative models, as serum deprivation (SD), excitotoxicity (presence of 500 μM glutamate in culture medium), as well as cisplatin toxicity (astroglia – 50 μM and oligodendroglia – 100 μM) was investigated. Cell viability in the tested cultures was assessed with the use of LDH and MTT methods. Moreover, 4BrABT ability to prevent the cisplatin-induced apoptosis in astrocyte and oligodendrocyte cultures was analysed after Hoechst 33342 fluorostaining. The obtained results indicate that 4BrABT was not toxic to neurons, astrocytes and oligodendrocytes. Moreover, a decrease in the neuronal LDH level was observed, which may suggest the ability of 4BrABT to act as a trophic agent. Furthermore, the protective action of the studied compound was shown in neuronal cultures exposed to neurotoxic conditions (presence of glutamate and trophic stress) and in cisplatin-treated astrocytes and oligodendrocytes. The expression of anticancer and neuroprotective activity raises hopes for the potential use of 4BrABT as a safe anticancer drug, or neuroprotective agent in chemotherapy-associated neurotoxicity.
Źródło:
Annals of Agricultural and Environmental Medicine; 2013, 20, 3
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Acute respiratory distress syndrome (ARDS) complicating influenza A/H1N1v infection – a clinical approach
Autorzy:
Witczak, A.
Prystupa, A.
Kurys-Denis, E.
Borys, M.
Czuczwar, M.
Niemcewicz, M.
Kocik, J.
Michalak, A.
Pietrzak, A.
Chodorowska, G.
Krupski, W.
Mosiewicz, J.
Tamasiewicz, K.
Powiązania:
https://bibliotekanauki.pl/articles/50695.pdf
Data publikacji:
2013
Wydawca:
Instytut Medycyny Wsi
Źródło:
Annals of Agricultural and Environmental Medicine; 2013, 20, 4
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Parity does not affect diabetes complications in women with type 1 diabetes
Autorzy:
Cypryk, K.
Grycewicz, J.
Świerzewska, P.
Kosiński, M.
Lewiński, A.
Żurawska-Klis, M.
Powiązania:
https://bibliotekanauki.pl/articles/2081577.pdf
Data publikacji:
2018
Wydawca:
Instytut Medycyny Wsi
Tematy:
diabetes
obstetric history
chronic complications
Opis:
Introduction. The problem concerning the impact of pregnancy on diabetic complications is a matter for discussion as there is some evidence suggesting that pregnancy may trigger development or progression of diabetic chronic complications. However, currently available data concerning this issue is still controversial. Objective. The aim of the study was to evaluate the impact of obstetric history on the development of chronic microangiopatic and macroangiopatic complications in type 1 diabetic women. Materials and Method. The retrospective study comprised 226 white Caucasian type 1 diabetic women, including 190 parous and 36 nulliparous women. Anthropometric data, information concerning the course of the disease, including metabolic control and chronic complications, together with obstetric history, were registered. Results. Parous women were older (p<0.001), but did not differ significantly regarding metabolic control in the course of the disease (p>0.05) and diabetes duration (p>0.05) from nulliparous subjects. There were no significant differences in the incidence (p>0.05) nor onset (p>0.05) of chronic diabetes complications between the groups. The number of deliveries did not correlate with either the incidence nor the onset of chronic complications. Longer DM duration at the moment of first delivery was related to the higher incidence of retinopathy (p<0.01), nephropathy (p<0.05) and neuropathy (p<0.001). Conclusions. The incidence of chronic diabetic complications does not differ between parous women and the subjects that were never pregnant, and is not related to the number of pregnancies.
Źródło:
Annals of Agricultural and Environmental Medicine; 2018, 25, 1; 114-119
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Cat Scratch Disease in a 1.5-year-old girl - case report
Autorzy:
Karski, J.
Matuszewski, L.
Okoński, M.
Pietrzyk, D.
Karska, K.
Załuski, M.
Powiązania:
https://bibliotekanauki.pl/articles/2081702.pdf
Data publikacji:
2018
Wydawca:
Instytut Medycyny Wsi
Tematy:
Cat Scratch Diseases
osteolisis
osteomyelitis
Opis:
Introduction. The paper is a case report presenting Cat Scratch Disease (CSD) in a 1.5-year- old girl. Bartoneloses, including CSD, are a group of infectious diseases which are rarely detected, therefore there are no statistical data concerning the aetiology, and the incidence of CSD noted in Poland is low in comparison with other European countries. Objective. The purpose of the paper is to discuss several problems related to CSD. Materials and method. A 1.5-year-old girl who was seen in hospital for the sparing use of her left arm when crawling. X-rays showed osteolytic lesions which radiologists described as multi-ocular cyst or infection. As neither clinical examination nor laboratory investigations found pathological signs, the patient was followed-up on an ambulant basis. Repeated x-ray taken 4 weeks later showed increased periosteal proliferation accompanied by pain. The baby was admitted to the Clinic but additional investigations found no pathologies. The baby was consulted by a rheumatologist and haematologist; however, they did not facilitate a definitive diagnosis. As the baby developed, because of a thickening of the soft tissues on the dorsal side of the distal epiphisis in the forearm the doctors decided to inspect the condition operatively. Macroscopic examination found brownish granulated tissue. Suction drainage was inserted and a tissue sample was tested for aerobic and anaerobic bacteria, tuberculosis and borelliosis. The test results were negative. The baby was in good condition, was not pyrexial and suffered from less pain. The diagnostics was further expanded and the baby tested for yersinia, chlamydia, tuberculosis and bartonella, i.e. CSD. The postoperative wound healed soon and radiological bony lesions began to resolve. After a month, we received a positive bartonella test result, the baby tested positively for Bartonella henselae IgG class, which confirmed past or active infection of CSD. A repeated test for B. henselae taken 6 months later showed a lower level of antibodies. Conclusions. It should be remembered that CSD, which is an extremely rare infection, can be diagnosed despite mediocre clinical and radiological manifestations. Thus, in the case of infections of unexplained aetiology and mediocre manifestations diagnostics should include testing for Bartonella henselae.
Źródło:
Annals of Agricultural and Environmental Medicine; 2018, 25, 2; 345-348
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Susac syndrome as a multidisciplinary diagnostic challenge
Autorzy:
Sapko, K.
Jamroz-Wiśniewska, A.
Woźniak, A.
Marciniec, M.
Kulczyński, M.
Janczarek, M.
Rejdak, R.
Rejdak, K.
Powiązania:
https://bibliotekanauki.pl/articles/28761861.pdf
Data publikacji:
2022
Wydawca:
Instytut Medycyny Wsi
Źródło:
Annals of Agricultural and Environmental Medicine; 2022, 29, 1; 157-161
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Efficacy and safety of insulin pump treatment in adult T1DM patients – influence of age and social environment
Autorzy:
Grzanka, M.
Matejko, B.
Cyganek, K.
Kozek, E.
Malecki, M.T.
Klupa, T.
Powiązania:
https://bibliotekanauki.pl/articles/51359.pdf
Data publikacji:
2012
Wydawca:
Instytut Medycyny Wsi
Opis:
Introduction and objective. Continuous subcutaneous insulin infusion (CSII) via personal insulin pump is a valuable therapeutic tool in T1DM patients. However, adherence to recommended CSII- related behaviours may be of concern to young adults with intensive, variable daily activities (students, young professionals). The aim of this observational study was to estimate treatment outcomes in young adult patients with T1DM, and compare them with older individuals. Materials and methods. Overall, 140 adults with T1DM on CSII were examined, divided into 2 subgroups: 77 patients younger than 26 years of age (mean 20.6 years) and 63 older subjects (mean 39.0). We compared the glycaemic control in both groups of T1DM subjects and analyzed treatment attitudes to identify potentially modifiable behaviours influencing the efficacy of the treatment. Results. The younger individuals were characterized by significantly worse treatment outcomes, compared to the older ones: the mean HbA1c levels were 7.6 ± 1.3% and 6.9±1.3% (p=0.00001), while the mean glucose levels based on glucometer downloads were 161±33.6 mg/dL and 136±21.8 mg/dL (p=0.00001), respectively. The frequency of self-monitoring of blood glucose (SMBG) was lower in younger individuals (5.3±2.1 vs. 7.0±2.8 daily, p=0.0005, respectively); they were also less frequently used advanced pump functions, e.g. the bolus calculator (48% vs. 67% users, p=0.0014, respectively). Conclusions. The efficacy of CSII treatment observed in young T1DM adults was worse than in older patients. The reason for this phenomenon remains unclear, it may be due simply to age-dependend behaviours, to social environment, or both.
Źródło:
Annals of Agricultural and Environmental Medicine; 2012, 19, 3
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The effect of MLS laser radiation on cell lipid membrane
Autorzy:
Pasternak, K.
Wróbel, D.
Nowacka, O.
Pieszyński, I.
Bryszewska, M.
Kujawa, J.
Powiązania:
https://bibliotekanauki.pl/articles/2081559.pdf
Data publikacji:
2018
Wydawca:
Instytut Medycyny Wsi
Tematy:
liposomes
laser irradiation
laser therapy
MLS M1 system
Opis:
Introduction. Authors of numerous publications have proved the therapeutic effect of laser irradiation on biological material, but the mechanisms at cellular and subcellular level are not yet well understood. Objective. The aim of this study was to assess the effect of laser radiation emitted by the MLS M1 system (Multiwave Locked System) at two wavelengths (808 nm continuous and 905 nm pulsed) on the stability and fluidity of liposomes with a lipid composition similar to that of human erythrocyte membrane or made of phosphatidylocholine. Materials and method. Liposomes were exposed to low-energy laser radiation at surface densities 195 mW/cm2 (frequency 1,000 Hz) and 230 mW/cm2 (frequency 2,000 Hz). Different doses of radiation energy in the range 0–15 J were applied. The surface energy density was within the range 0.46 – 4.9 J/cm2. Results. The fluidity and stability of liposomes subjected to such irradiation changed depending on the parameters of radiation used. Conclusions. Since MLS M1 laser radiation, depending on the parameters used, affects fluidity and stability of liposomes with the lipid content similar to erythrocyte membrane, it may also cause structural and functional changes in cell membranes.
Źródło:
Annals of Agricultural and Environmental Medicine; 2018, 25, 1; 108-113
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Cryptosporidium parvum – zoonotic subtype IIdA15G1 in a Slovakian patient
Autorzy:
Mravcova, K.
Strkolcova, G.
Mucha, R.
Barbusinova, E.
Goldova, M.
Kacirova, J.
Madar, M.
Powiązania:
https://bibliotekanauki.pl/articles/2085903.pdf
Data publikacji:
2020
Wydawca:
Instytut Medycyny Wsi
Tematy:
Slovakia
nested PCR
Cryptosporidium spp
zoonotic subtype
veterinary student
Opis:
Introduction and objectives. The parasite Cryptosporidium spp. is an intracellular protozoa which has a broad range of hosts and zoonotic potential. It presents a serious health risk for agricultural workers and veterinarians. The aim of the study was to identify the species and subtypes of Cryptosporidium occurring in a veterinary student who came into contact with calves on a farm. Materials and method. The Ziehl-Neelsen staining technique was employed to confirm the presence of Cryptosporidium oocysts. ELISA test was applied to detect coproantigen in faecal specimens. Nested PCR was used to amplify a small ribosomal subunit (SSU rRNA) and sequencing of the GP60 gene served to identify the zoonotic subtypes. Results. The nested PCR allowed to confirm the C. parvum species; subsequently, the IIdA15G1 zoonotic subtype was identified. Conclusion. This is the first confirmed case in Slovakia of human cryptosporidiosis caused by the unique subtype IIdA15G1.
Źródło:
Annals of Agricultural and Environmental Medicine; 2020, 27, 3; 485-488
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Wyświetlanie 1-15 z 48

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